PMID- 37697944
OWN - NLM
STAT- MEDLINE
DCOM- 20231220
LR  - 20240314
IS  - 2573-8348 (Electronic)
IS  - 2573-8348 (Linking)
VI  - 6
IP  - 12
DP  - 2023 Dec
TI  - The influence of partial gastrectomy for gastric cancer on the spontaneous 
      disappearance of Helicobacter pylori: A single-center prospective study.
PG  - e1903
LID - 10.1002/cnr2.1903 [doi]
LID - e1903
AB  - BACKGROUND/AIMS: Helicobacter pylori (HP) eradication is recommended after 
      endoscopic treatment of early gastric cancer (EGC). Cases of spontaneous HP 
      resolution after partial gastrectomy due to environmental changes have been 
      reported; however, there is no evidence for the efficacy of HP eradication in 
      suppressing carcinogenesis and also no reports on the natural history of HP after 
      partial gastrectomy in gastric cancer (GC). To report the natural history of HP 
      in patients with GC and HP infection after partial gastrectomy. METHODS AND 
      RESULTS: We prospectively studied the rate of spontaneous disappearance of HP 
      after partial gastrectomy in patients with GC. From April 2016 to May 2020, 80 
      patients underwent partial gastrectomy, including 9 cases of proximal gastrectomy 
      (PG), and 71 cases of distal gastrectomy (DG). The presence of HP was confirmed 
      in the stool antigen test 1 year after operation, HP infection persisted in 46 
      patients (57.5%) and disappeared in 34 patients (42.5%). In univariate analysis, 
      only proton pump inhibitor (PPI) use was a significant contributing factor for 
      the spontaneous resolution of HP infection, especially in the DG group. However, 
      there was no difference in the rates of HP disappearance between Billroth-I and 
      Roux-en-Y reconstructions in the DG group. CONCLUSION: The HP spontaneously 
      disappeared in 42.5% of the GC patients within 1 year after partial gastrectomy. 
      Further investigation in a larger cohort is needed to elucidate the underlying 
      mechanisms.
CI  - (c) 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.
FAU - Yanagawa, Senichiro
AU  - Yanagawa S
AUID- ORCID: 0000-0002-3076-8622
AD  - Department of Surgery, Onomichi General Hospital, Hiroshima, Japan.
FAU - Fujikuni, Nobuaki
AU  - Fujikuni N
AUID- ORCID: 0009-0009-8702-6601
AD  - Department of Surgery, Onomichi General Hospital, Hiroshima, Japan.
AD  - Department of Digestive Surgery, Hiroshima Prefectural Hospital, Hiroshima, 
      Japan.
FAU - Tanabe, Kazuaki
AU  - Tanabe K
AUID- ORCID: 0000-0002-8650-2735
AD  - Department of Perioperative and Critical Care Management, Graduate School of 
      Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
FAU - Nakahara, Masahiro
AU  - Nakahara M
AUID- ORCID: 0009-0007-5564-0610
AD  - Department of Surgery, Onomichi General Hospital, Hiroshima, Japan.
FAU - Noriyuki, Toshio
AU  - Noriyuki T
AUID- ORCID: 0000-0002-0037-0496
AD  - Department of Surgery, Onomichi General Hospital, Hiroshima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230912
PL  - United States
TA  - Cancer Rep (Hoboken)
JT  - Cancer reports (Hoboken, N.J.)
JID - 101747728
SB  - IM
MH  - Humans
MH  - Prospective Studies
MH  - *Helicobacter pylori
MH  - *Stomach Neoplasms/surgery
MH  - Gastrectomy/adverse effects
MH  - *Helicobacter Infections/complications/diagnosis/epidemiology
PMC - PMC10728519
OTO - NOTNLM
OT  - Helicobacter pylori
OT  - gastric cancer
OT  - partial gastrectomy
OT  - spontaneous disappearance
COIS- The authors have stated explicitly that there are no conflicts of interest in 
      connection with this article.
EDAT- 2023/09/12 06:41
MHDA- 2023/12/20 06:42
PMCR- 2023/09/12
CRDT- 2023/09/12 04:13
PHST- 2023/08/02 00:00 [revised]
PHST- 2023/04/23 00:00 [received]
PHST- 2023/08/27 00:00 [accepted]
PHST- 2023/12/20 06:42 [medline]
PHST- 2023/09/12 06:41 [pubmed]
PHST- 2023/09/12 04:13 [entrez]
PHST- 2023/09/12 00:00 [pmc-release]
AID - CNR21903 [pii]
AID - 10.1002/cnr2.1903 [doi]
PST - ppublish
SO  - Cancer Rep (Hoboken). 2023 Dec;6(12):e1903. doi: 10.1002/cnr2.1903. Epub 2023 Sep 
      12.