PMID- 37698834
OWN - NLM
STAT- MEDLINE
DCOM- 20240227
LR  - 20240227
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 61
IP  - 3
DP  - 2024 Mar
TI  - Screening for Differentially Expressed Memory Genes on a Diabetes Model Induced 
      by High-Sugar Diet in Drosophila melanogaster: Potential Markers for Memory 
      Deficits.
PG  - 1225-1236
LID - 10.1007/s12035-023-03598-z [doi]
AB  - Type 2 diabetes mellitus (T2DM) has been shown to affect a series of cognitive 
      processes including memory, increasing the risk for dementia, particularly 
      Alzheimer's disease (AD). Although increasing evidence has supported that both 
      diseases share common features, the pathophysiological mechanisms connecting 
      these two disorders remain to be fully elucidated. Herein, we used Drosophila 
      melanogaster fed on a high-sugar diet (HSD) to mimic T2DM, and investigate its 
      effects on memory as well as identify potential molecular players associated with 
      the memory deficits induced by HSD. Flies hatched from and reared on HSD for 
      7 days had a substantial decrease in short-term memory (STM). The screening for 
      memory-related genes using transcriptome data revealed that HSD altered the 
      expression of 33% of memory genes in relation to the control. Among the 
      differentially expressed genes (DEGs) with a fold change (FC) higher than two, we 
      found five genes, related to synapse and memory trace formation, that could be 
      considered strong candidates to underlie the STM deficits in HSD flies: Abl 
      tyrosine kinase (Abl), bruchpilot (Brp), minibrain (Mnb), shaker (Sh), and 
      gilgamesh (Gish). We also analyzed genes from the dopamine system, one of the 
      most relevant signaling pathways for olfactory memory. Interestingly, the flies 
      fed on HSD presented a decreased expression of the Tyrosine hydroxylase (Ple) and 
      Dopa decarboxylase (Ddc) genes, signals of a possible dopamine deficiency. In 
      this work, we present promising biomarkers to investigate molecular networks 
      shared between T2DM and AD.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Loreto, Julia Sepel
AU  - Loreto JS
AD  - Centro de Ciencias Naturais E Exatas, Programa de Pos-Graduacao Em Bioquimica 
      Toxicologica, Universidade Federal de Santa Maria, Avenida Roraima, Santa Maria, 
      RS, 1000, 97105-900, Brazil.
FAU - Ferreira, Sabrina Antunes
AU  - Ferreira SA
AD  - Centro de Ciencias Naturais E Exatas, Programa de Pos-Graduacao Em Bioquimica 
      Toxicologica, Universidade Federal de Santa Maria, Avenida Roraima, Santa Maria, 
      RS, 1000, 97105-900, Brazil.
FAU - de Almeida, Pamela
AU  - de Almeida P
AD  - Centro de Ciencias Naturais E Exatas, Programa de Pos-Graduacao Em Bioquimica 
      Toxicologica, Universidade Federal de Santa Maria, Avenida Roraima, Santa Maria, 
      RS, 1000, 97105-900, Brazil.
FAU - da Rocha, Joao Batista Teixeira
AU  - da Rocha JBT
AD  - Centro de Ciencias Naturais E Exatas, Programa de Pos-Graduacao Em Bioquimica 
      Toxicologica, Universidade Federal de Santa Maria, Avenida Roraima, Santa Maria, 
      RS, 1000, 97105-900, Brazil.
FAU - Barbosa, Nilda Vargas
AU  - Barbosa NV
AUID- ORCID: 0000-0002-3661-4253
AD  - Centro de Ciencias Naturais E Exatas, Programa de Pos-Graduacao Em Bioquimica 
      Toxicologica, Universidade Federal de Santa Maria, Avenida Roraima, Santa Maria, 
      RS, 1000, 97105-900, Brazil. nvbarbosa@yahoo.com.br.
LA  - eng
GR  - 306919/2020-6/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
GR  - 88887.654237/2021-00/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
PT  - Journal Article
DEP - 20230912
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - VTD58H1Z2X (Dopamine)
RN  - 0 (Sugars)
SB  - IM
MH  - Animals
MH  - Drosophila melanogaster/metabolism
MH  - *Diabetes Mellitus, Type 2
MH  - Dopamine/metabolism
MH  - Memory Disorders/genetics
MH  - *Alzheimer Disease
MH  - Diet
MH  - Sugars/metabolism/pharmacology
OTO - NOTNLM
OT  - D. melanogaster
OT  - Diabetes
OT  - High-sugar diet
OT  - Memory
OT  - Synaptic plasticity
EDAT- 2023/09/12 12:41
MHDA- 2024/02/27 06:44
CRDT- 2023/09/12 11:24
PHST- 2023/06/01 00:00 [received]
PHST- 2023/08/18 00:00 [accepted]
PHST- 2024/02/27 06:44 [medline]
PHST- 2023/09/12 12:41 [pubmed]
PHST- 2023/09/12 11:24 [entrez]
AID - 10.1007/s12035-023-03598-z [pii]
AID - 10.1007/s12035-023-03598-z [doi]
PST - ppublish
SO  - Mol Neurobiol. 2024 Mar;61(3):1225-1236. doi: 10.1007/s12035-023-03598-z. Epub 
      2023 Sep 12.