PMID- 37701509
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 0973-2063 (Print)
IS  - 0973-2063 (Electronic)
IS  - 0973-2063 (Linking)
VI  - 18
IP  - 12
DP  - 2022
TI  - Association of interleukin 6 and uric acid levels in patients with type 2 
      diabetes mellitus.
PG  - 1136-1140
LID - 10.6026/973206300181136 [doi]
AB  - Type 2 Diabetes Mellitus (T2DM) patients with coronary artery disease (CAD) 
      coupled with hypertension (HTN) are leading cause of morbidity and mortality. 
      Association of Interleukin 6 and uric acid levels can be used for early detection 
      of CAD in patients with T2DM. This cross sectional study included 120 study 
      participants, were sub grouped into three Group 1: controls (n=30), Group 2: CAD, 
      HTN without T2DM (n=30) and Group 3: CAD, HTN with T2DM (n=30). Basic 
      biochemical, clinical and experimental parameters were analysed and recorded for 
      all the study subjects. The statistical analysis was done by using the SPSS 20.0. 
      Individuals with CAD, HTN with T2DM had higher BMI, weight, SBP, and DBP levels 
      than patients CAD, HTN without diabetes and controls. In CAD, HTN with T2DM study 
      participants has been found to have higher serum levels of inflammatory cytokines 
      like IL-6 and uric acids when compared to CAD, HTN without T2DM and controls. IL6 
      was significantly positive association with uric acid and negative association 
      with age and HDL. These findings demonstrated a statistically significant 
      positive connection between IL-6, and uric acid concentrations. The identified 
      elevated levels of inflammatory cytokines and uric acids in type 2 diabetic and 
      hypertensive CAD patients may aid in the identification of patients at higher 
      risk.
CI  - (c) 2022 Biomedical Informatics.
FAU - Gutlur Nagarajaiah, Setty Raghav
AU  - Gutlur Nagarajaiah SR
AD  - Department of General Medicine, Rajarajeswari Medical College and Hospital, 
      Bangalore - 560074, Karnataka, India.
FAU - Somashekar, Pallavi
AU  - Somashekar P
AD  - Department of General Medicine, Akash Institute of Medical Sciences and Research 
      Centre, Bangalore - 562110, Karnataka, India.
FAU - Hareesh, Rangaswamaiah
AU  - Hareesh R
AD  - Department of General Medicine, Akash Institute of Medical Sciences and Research 
      Centre, Bangalore - 562110, Karnataka, India.
FAU - Veluri, Ganesh
AU  - Veluri G
AD  - Department of Biochemistry, Akash Institute of Medical Sciences and Research 
      Centre, Bangalore - 562110, Karnataka, India.
LA  - eng
PT  - Journal Article
DEP - 20221231
PL  - Singapore
TA  - Bioinformation
JT  - Bioinformation
JID - 101258255
PMC - PMC10492914
OTO - NOTNLM
OT  - Coronary Artery Disease
OT  - Hypertension
OT  - T2DM and Interleukin 6
EDAT- 2023/09/13 06:41
MHDA- 2023/09/13 06:42
PMCR- 2022/01/01
CRDT- 2023/09/13 04:07
PHST- 2022/11/01 00:00 [received]
PHST- 2022/12/20 00:00 [revised]
PHST- 2022/12/31 00:00 [accepted]
PHST- 2023/09/13 06:42 [medline]
PHST- 2023/09/13 06:41 [pubmed]
PHST- 2023/09/13 04:07 [entrez]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 973206300181136 [pii]
AID - 10.6026/973206300181136 [doi]
PST - epublish
SO  - Bioinformation. 2022 Dec 31;18(12):1136-1140. doi: 10.6026/973206300181136. 
      eCollection 2022.