PMID- 37702010
OWN - NLM
STAT- MEDLINE
DCOM- 20231206
LR  - 20231206
IS  - 1098-2744 (Electronic)
IS  - 0899-1987 (Linking)
VI  - 63
IP  - 1
DP  - 2024 Jan
TI  - FOLR1-stabilized beta-catenin promotes laryngeal carcinoma progression through 
      EGFR/AKT/GSK-3beta pathway.
PG  - 34-44
LID - 10.1002/mc.23634 [doi]
AB  - Folate receptor 1 (FOLR1) is overexpressed in numerous epithelial malignancies; 
      however, its role in laryngeal squamous cell carcinoma (LSCC) remains unclear. In 
      the present study, we demonstrated that FOLR1 messenger RNA and protein 
      expression levels were higher in LSCC tissues than in the adjacent normal 
      tissues. Additionally, FOLR1 promoted the proliferation and migration of LSCC 
      cells, whereas small interfering RNA-mediated knockdown of beta-catenin abolished 
      these effects. Moreover, FOLR1 stabilizes beta-catenin by inhibiting its 
      ubiquitination and degradation. Furthermore, blocking the interaction between 
      epidermal growth factor receptor (EGFR) and the EGFR/AKT/glycogen synthase 
      (GSK)3beta signaling axis both abolished FOLR1's effects on the expression and 
      nuclear aggregation of beta-catenin. In summary, our work reveals a novel mode in 
      which FOLR1 promotes the proliferation and migration of LSCC by enhancing the 
      stability and nuclear translocation of beta-catenin through the EGFR/AKT/GSK3beta axis.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Tuo, Huawei
AU  - Tuo H
AD  - Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, 
      Shiyan, China.
FAU - Li, Xuemei
AU  - Li X
AD  - Department of Dermatology, Huazhong University of Science and Technology Union 
      Shenzhen Hospital, Shenzhen, China.
FAU - Du, Haixia
AU  - Du H
AD  - Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, 
      Shiyan, China.
FAU - Li, Man
AU  - Li M
AD  - Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, 
      Shiyan, China.
FAU - Xu, Chenli
AU  - Xu C
AD  - Department of Pathology, School of Basic Medical Science, Hubei University of 
      Medicine, Shiyan, China.
FAU - Yu, Zizhong
AU  - Yu Z
AD  - Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine, 
      Shiyan, China.
FAU - Zhao, Huzi
AU  - Zhao H
AUID- ORCID: 0000-0002-5075-771X
AD  - Department of Pathology, School of Basic Medical Science, Hubei University of 
      Medicine, Shiyan, China.
LA  - eng
PT  - Journal Article
DEP - 20230913
PL  - United States
TA  - Mol Carcinog
JT  - Molecular carcinogenesis
JID - 8811105
RN  - 0 (beta Catenin)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - 0 (Folate Receptor 1)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - 0 (FOLR1 protein, human)
RN  - EC 2.7.10.1 (EGFR protein, human)
SB  - IM
MH  - Humans
MH  - *beta Catenin/genetics/metabolism
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Glycogen Synthase Kinase 3 beta/genetics/metabolism
MH  - Folate Receptor 1
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - *Head and Neck Neoplasms
MH  - ErbB Receptors/genetics/metabolism
MH  - Cell Proliferation/genetics
MH  - Cell Line, Tumor
OTO - NOTNLM
OT  - EGFR
OT  - FOLR1
OT  - laryngeal carcinoma
OT  - ubiquitination
OT  - beta-catenin
EDAT- 2023/09/13 06:41
MHDA- 2023/12/06 06:42
CRDT- 2023/09/13 04:33
PHST- 2023/08/21 00:00 [revised]
PHST- 2023/04/21 00:00 [received]
PHST- 2023/09/06 00:00 [accepted]
PHST- 2023/12/06 06:42 [medline]
PHST- 2023/09/13 06:41 [pubmed]
PHST- 2023/09/13 04:33 [entrez]
AID - 10.1002/mc.23634 [doi]
PST - ppublish
SO  - Mol Carcinog. 2024 Jan;63(1):34-44. doi: 10.1002/mc.23634. Epub 2023 Sep 13.