PMID- 37704821
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 47
DP  - 2023 Oct
TI  - The association of the serum levels of aldehydes with diabetes-related eye 
      diseases: a cross-sectional population-based study.
PG  - 104713-104725
LID - 10.1007/s11356-023-29750-9 [doi]
AB  - Diabetes could impact many ocular tissues. However, the association of the serum 
      aldehydes with diabetes-related eye diseases (DED) remains unclear. Thus, we 
      aimed to examine the above relationship from the general US population of 
      2013-2014 National Health and Nutrition Examination Survey (NHANES). The 
      multivariable logistic regression and Bayesian kernel machine regression (BKMR) 
      were used to analyze the effect of serum aldehydes on the risk of DED. Pearson's 
      correlation analysis, the restricted cubic spline (RCS) model, and the linear 
      regression were performed to explore the association between the serum aldehydes 
      and other parameters. The multivariable linear regression was conducted to 
      further underlie the relationship between the serum aldehydes and the 
      glycohemoglobin A1c (HbA1c) in DED participants. Although no significant 
      association was observed between the serum aldehydes and the risk of DED by the 
      multivariable logistic regression and BKMR, the Pearson correlation revealed a 
      positive association between the HbA1c level and the serum level of 
      heptanaldehyde and isopentanaldehyde in DED participants. The RCS model confirmed 
      the above linear correlation. After adjusting for the cofounding factor of 
      smoking, the multivariable linear regression revealed a significant association 
      between the serum level of heptanaldehyde and the HbA1c level in DED 
      participants. Our results suggest that aldehyde exposure did not significantly 
      increase the risk of DED, while heptanaldehyde was the risk factor for increased 
      HbA1c in DED population.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Yan, Weiming
AU  - Yan W
AD  - Department of Ophthalmology, Fuzong Clinical Medical College of Fujian Medical 
      University, Fuzhou, 350025, China. 742666007@qq.com.
FAU - Sun, Yan
AU  - Sun Y
AD  - Department of Ophthalmology, Fuzong Clinical Medical College of Fujian Medical 
      University, Fuzhou, 350025, China.
FAU - Wang, Yutong
AU  - Wang Y
AD  - Department of Ophthalmology, Fuzong Clinical Medical College of Fujian Medical 
      University, Fuzhou, 350025, China.
FAU - Liu, Yubin
AU  - Liu Y
AD  - Department of Ophthalmology, Fuzong Clinical Medical College of Fujian Medical 
      University, Fuzhou, 350025, China.
FAU - Yan, Weihua
AU  - Yan W
AD  - Department of Ophthalmology, Fuzong Clinical Medical College of Fujian Medical 
      University, Fuzhou, 350025, China.
FAU - Li, Dongling
AU  - Li D
AD  - Department of Hepatobiliary Disease, Fuzong Clinical Medical College of Fujian 
      Medical University, PLA, Fuzhou, 350025, China.
FAU - Chen, Meizhu
AU  - Chen M
AD  - Department of Ophthalmology, Fuzong Clinical Medical College of Fujian Medical 
      University, Fuzhou, 350025, China.
LA  - eng
PT  - Journal Article
DEP - 20230914
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Aldehydes)
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Humans
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - Aldehydes
MH  - Glycated Hemoglobin
MH  - Bayes Theorem
MH  - *Diabetes Mellitus
MH  - *Eye Diseases
MH  - *Diabetes Complications
OTO - NOTNLM
OT  - Aldehydes
OT  - Diabetes
OT  - Diabetes-related eye diseases
OT  - HbA1c
OT  - Multivariable linear regression
EDAT- 2023/09/14 00:42
MHDA- 2023/10/23 00:44
CRDT- 2023/09/13 23:31
PHST- 2023/05/06 00:00 [received]
PHST- 2023/09/03 00:00 [accepted]
PHST- 2023/10/23 00:44 [medline]
PHST- 2023/09/14 00:42 [pubmed]
PHST- 2023/09/13 23:31 [entrez]
AID - 10.1007/s11356-023-29750-9 [pii]
AID - 10.1007/s11356-023-29750-9 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Oct;30(47):104713-104725. doi: 
      10.1007/s11356-023-29750-9. Epub 2023 Sep 14.