PMID- 37705960
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230916
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 26
IP  - 9
DP  - 2023 Sep 15
TI  - Laeverin/aminopeptidase Q induces indoleamine 2,3-dioxygenase-1 in human 
      monocytes.
PG  - 107692
LID - 10.1016/j.isci.2023.107692 [doi]
LID - 107692
AB  - Human extravillous trophoblast (EVT) invades the maternal endometrium and 
      reconstructs uterine spiral arteries cooperatively with maternal immune cells. 
      Although EVT has allogeneic paternal antigens, the maternal immune system does 
      not reject it. Here, we found that laeverin (LVRN), an EVT-specific cell surface 
      peptidase, interacts with monocytes to produce indoleamine 2,3-dioxygenase-1 
      (IDO1). LVRN-transfected Swan71 cells, a cytotrophoblast-derived cell line, and 
      increased IDO1 expression in PBMC under cell-to-cell interacting conditions. 
      Soluble recombinant LVRN (r-LVRN) interacted with CD14-positive monocytes and 
      induced their IDO1 expression without the intervention of other immune cell 
      populations. LVRN-induced IDO1 production was promoted in PMA-activated 
      monocyte-like THP-1 cells. Furthermore, r-LVRN decreased the tryptophan level and 
      increased the kynurenine/tryptophan ratio in the culture media of the PMA-treated 
      THP-1 cells. These findings suggest that LVRN is one of the key molecules that 
      mediate the interaction between EVT and monocytes/macrophages and creates an 
      immunosuppressive environment at the maternal-fetal interface in the uterus.
CI  - (c) 2023 The Author(s).
FAU - Suzuki, Takuma
AU  - Suzuki T
AD  - Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, 
      Kanazawa University, Kanazawa, Japan.
FAU - Iizuka, Takashi
AU  - Iizuka T
AD  - Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, 
      Kanazawa University, Kanazawa, Japan.
FAU - Kagami, Kyosuke
AU  - Kagami K
AD  - Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, 
      Kanazawa University, Kanazawa, Japan.
FAU - Matsumoto, Takeo
AU  - Matsumoto T
AD  - Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, 
      Kanazawa University, Kanazawa, Japan.
FAU - Yamazaki, Rena
AU  - Yamazaki R
AD  - Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, 
      Kanazawa University, Kanazawa, Japan.
FAU - Daikoku, Takiko
AU  - Daikoku T
AD  - Division of Animal Disease Model, Research Center for Experimental Modeling of 
      Human Disease, Kanazawa University, Kanazawa, Japan.
FAU - Horie, Akihito
AU  - Horie A
AD  - Department of Gynecology and Obstetrics, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
FAU - Ono, Masanori
AU  - Ono M
AD  - Department of Obstetrics and Gynecology, Tokyo Medical University, Shinjuku, 
      Tokyo 160-0023, Japan.
FAU - Hattori, Akira
AU  - Hattori A
AD  - Department of System Chemotherapy and Molecular Sciences, Kyoto University 
      Graduate School of Pharmaceutical Sciences, Kyoto, Japan.
FAU - Fujiwara, Hiroshi
AU  - Fujiwara H
AD  - Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, 
      Kanazawa University, Kanazawa, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230819
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC10495628
OTO - NOTNLM
OT  - Developmental biology
OT  - Embryology
OT  - Molecular biology
COIS- The authors declare no competing interests.
EDAT- 2023/09/14 06:43
MHDA- 2023/09/14 06:44
PMCR- 2023/08/19
CRDT- 2023/09/14 04:10
PHST- 2023/03/23 00:00 [received]
PHST- 2023/05/23 00:00 [revised]
PHST- 2023/08/17 00:00 [accepted]
PHST- 2023/09/14 06:44 [medline]
PHST- 2023/09/14 06:43 [pubmed]
PHST- 2023/09/14 04:10 [entrez]
PHST- 2023/08/19 00:00 [pmc-release]
AID - S2589-0042(23)01769-8 [pii]
AID - 107692 [pii]
AID - 10.1016/j.isci.2023.107692 [doi]
PST - epublish
SO  - iScience. 2023 Aug 19;26(9):107692. doi: 10.1016/j.isci.2023.107692. eCollection 
      2023 Sep 15.