PMID- 37705973
OWN - NLM
STAT- MEDLINE
DCOM- 20230915
LR  - 20230916
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - Glial autoantibody prevalence in Chinese optic neuritis with onset after age 45: 
      clinical factors for diagnosis.
PG  - 1181908
LID - 10.3389/fimmu.2023.1181908 [doi]
LID - 1181908
AB  - PURPOSE: As glial autoantibody testing is not yet available in some areas of the 
      world, an alternative approach is to use clinical indicators to predict which 
      subtypes of middle-aged and elderly-onset optic neuritis (ON) have manifested. 
      METHOD: This study was a single-center hospital-based retrospective cohort study. 
      Middle-aged and elderly-onset ON patients (age > 45 years) who had experienced 
      the first episode of ON were included in this cohort. Single- and 
      multi-parametric diagnostic factors for middle-aged and elderly-onset myelin 
      oligodendrocyte glycoprotein immunoglobulin-associated ON (MOG-ON) and 
      aquaporin-4 immunoglobulin-related ON (AQP4-ON) were calculated. RESULTS: From 
      January 2016 to January 2020, there were 81 patients with middle-aged and 
      elderly-onset ON, including 32 (39.5%) AQP4-ON cases, 19 (23.5%) MOG-ON cases, 
      and 30 (37.0%) Seronegative-ON cases. Bilateral involvement (47.4%, P = 0.025) 
      was most common in the MOG-ON group. The presence of other concomitant autoimmune 
      antibodies (65.6%, P = 0.014) and prior neurological history (37.5%, P = 0.001) 
      were more common in the AQP4-ON group. The MOG-ON group had the best follow-up 
      best-corrected visual acuity (BCVA) (89.5% </= 1.0 LogMAR, P = 0.001). The most 
      sensitive diagnostic factors for middle-aged and elderly-onset MOG-ON were 
      'follow-up VA </= 0.1 logMAR' (sensitivity 0.89), 'bilateral involvement or 
      follow-up VA </= 0.1 logMAR' (sensitivity 0.95), 'bilateral involvement or without 
      neurological history' (sensitivity 1.00), and 'follow-up VA </= 0.1 logMAR or 
      without neurological history' (sensitivity 1.00), and the most specific factor 
      was 'bilateral involvement' (specificity 0.81). The most sensitive diagnostic 
      factors for middle-aged and elderly-onset AQP4-ON were 'unilateral involvement' 
      (sensitivity 0.88), 'unilateral involvement or neurological history' (sensitivity 
      0.91), and 'unilateral involvement or other autoimmune antibodies' (sensitivity 
      1.00), and the most specific factor was neurological history (specificity 0.98). 
      CONCLUSION: Based on our cohort study of middle-aged and elderly-onset ON, MOG-ON 
      is less prevalent than AQP4-ON and Seronegative-ON. Using multiple combined 
      parameters improves the sensitivity and negative predictive value for diagnosing 
      middle-aged and elderly-onset MOG-ON and AQP4-ON. These combined parameters can 
      help physicians identify and treat middle-aged and elderly-onset ON early when 
      glial autoantibody status is not available.
CI  - Copyright (c) 2023 Song, Chuai, Yang, Zhou, Sun, Xu and Wei.
FAU - Song, Honglu
AU  - Song H
AD  - Department of Ophthalmology, The First Medical Center of the Chinese People's 
      Liberation Army General Hospital, Beijing, China.
AD  - Department of Ophthalmology, Bethune International Peace Hospital, Shijiazhuang, 
      Hebei, China.
FAU - Chuai, Yucai
AU  - Chuai Y
AD  - Department of Special Medical Services, Bethune International Peace Hospital, 
      Shijiazhuang, Hebei, China.
FAU - Yang, Mo
AU  - Yang M
AD  - Department of Neuro-ophthalmology, Eye Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Zhou, Huanfen
AU  - Zhou H
AD  - Department of Ophthalmology, The First Medical Center of the Chinese People's 
      Liberation Army General Hospital, Beijing, China.
FAU - Sun, Mingming
AU  - Sun M
AD  - Department of Ophthalmology, The First Medical Center of the Chinese People's 
      Liberation Army General Hospital, Beijing, China.
FAU - Xu, Quangang
AU  - Xu Q
AD  - Department of Ophthalmology, The First Medical Center of the Chinese People's 
      Liberation Army General Hospital, Beijing, China.
FAU - Wei, Shihui
AU  - Wei S
AD  - Department of Ophthalmology, The First Medical Center of the Chinese People's 
      Liberation Army General Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230829
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Humans
MH  - *Autoantibodies
MH  - Cohort Studies
MH  - East Asian People
MH  - *Optic Neuritis/diagnosis/epidemiology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Middle Aged
MH  - Aged
PMC - PMC10495982
OTO - NOTNLM
OT  - aquaporin 4
OT  - diagnostic test
OT  - glial autoantibody
OT  - middle-aged and elderly-onset
OT  - myelin oligodendrocyte glycoprotein
OT  - optic neuritis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/09/14 06:42
MHDA- 2023/09/15 06:42
PMCR- 2023/01/01
CRDT- 2023/09/14 04:11
PHST- 2023/03/08 00:00 [received]
PHST- 2023/08/08 00:00 [accepted]
PHST- 2023/09/15 06:42 [medline]
PHST- 2023/09/14 06:42 [pubmed]
PHST- 2023/09/14 04:11 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1181908 [doi]
PST - epublish
SO  - Front Immunol. 2023 Aug 29;14:1181908. doi: 10.3389/fimmu.2023.1181908. 
      eCollection 2023.