PMID- 37708541
OWN - NLM
STAT- MEDLINE
DCOM- 20231204
LR  - 20231204
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
VI  - 29
IP  - 8
DP  - 2023 Nov
TI  - Analysis of HLA Profiles in 390 Uveitis Cases: Insights into Clinical 
      Presentations.
PG  - 717-721
LID - AT9084 [pii]
AB  - OBJECTIVE: This study aimed to explain the associations between different types 
      of uveitis and human leukocyte antigen (HLA)-B27, HLA-DR4, and HLA-DRw53. 
      METHODS: A retrospective analysis of 390 uveitis cases was conducted among 
      inpatients and outpatients diagnosed at Weifang Eye Hospital from 2013 to 2016. 
      All 390 patients underwent HLA-B27 examination, and an additional 40 patients 
      underwent examination for HLA-DR4 and HLA-DRw53. Gender, age, corrected visual 
      acuity (CVA), and recurrence frequency were statistically analyzed based on the 
      onset site and etiology classification. RESULTS: Among the 390 enrolled patients, 
      206 were male, and 183 were female, with ages ranging from 6 to 87 years (mean: 
      44.2). The disease onset was classified into anterior uveitis (AU), panuveitis 
      (panU), posterior uveitis (PU), and intermediate uveitis in 180, 112, 88, and 10 
      cases, respectively. HLA-B27 was positive in 94 cases (53 males and 41 females), 
      yielding a positive rate of 24.1%. In AU patients, 80 (44.4%) tested positive for 
      HLA-B27, while 8 (7.1%) panU patients and 6 PU patients (6.8%) were HLA-B27 
      positive; none of the intermediate uveitis (IU) patients exhibited HLA-B27 
      positivity. HLA-B27, HLA-DR4, and HLA-DRw53 examinations were performed on 40 
      patients with binocular uveitis, resulting in 2 HLA-B27 positive cases, 15 
      HLA-DR4 positive cases, and 20 HLA-DRw53 positive cases, with positive rates of 
      5%, 37.5%, and 50%, respectively. Among 25 Vogt Koyanagi-Harada (VKH) cases, 1 
      tested positive for HLA-B27, 22 were positive for HLA-DR4, and 24 were positive 
      for HLA-DRw53, with positive rates of 4%, 88%, and 96%, respectively. No positive 
      HLA-B27, HLA-DR4, or HLA-DRw53 cases were found among the 10 cases of Behcet's 
      disease (BD). CONCLUSIONS: Human leukocyte antigens (HLAs) play a significant 
      role in the mechanism of uveitis. HLA-B27 exhibits high diagnostic value in acute 
      AU, while HLA-DR4 and HLA-DRw53 are crucial for diagnosing binocular uveitis, 
      particularly Vogt Koyanagi-Harada (VKH) syndrome. Further investigation is 
      warranted to explore the relationship between HLA-DR4, HLA-DRw53, and uveitis.
FAU - Li, Shouqing
AU  - Li S
FAU - Yan, Liqiang
AU  - Yan L
FAU - Li, Mengxue
AU  - Li M
FAU - Fan, Ningning
AU  - Fan N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - HLA-B27 Antigen
MH  - HLA-DR4 Antigen
MH  - Retrospective Studies
MH  - *Uveitis/diagnosis
MH  - HLA Antigens
MH  - *Uveomeningoencephalitic Syndrome
MH  - *Uveitis, Intermediate
EDAT- 2023/09/14 18:43
MHDA- 2023/12/04 12:42
CRDT- 2023/09/14 17:32
PHST- 2023/12/04 12:42 [medline]
PHST- 2023/09/14 18:43 [pubmed]
PHST- 2023/09/14 17:32 [entrez]
AID - AT9084 [pii]
PST - ppublish
SO  - Altern Ther Health Med. 2023 Nov;29(8):717-721.