PMID- 37709853
OWN - NLM
STAT- MEDLINE
DCOM- 20240311
LR  - 20240311
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 95
IP  - 4
DP  - 2024 Mar
TI  - Maternal periconceptional folic acid supplementation and risk for fetal 
      congenital genitourinary system defects.
PG  - 1132-1138
LID - 10.1038/s41390-023-02808-7 [doi]
AB  - BACKGROUND: Taking folic acid supplementation could reduce the risk of neural 
      tube defects for offspring in the maternal periconceptional period, but the 
      relationship between folic acid use and other birth defects remains unclear, such 
      as genitourinary system birth defects. METHODS: The data from a Prenatal Health 
      Care System and Birth Defects Surveillance System in Tongzhou, Beijing, China, 
      were collected from 2013 to 2018. We adjusted for differences in characteristics 
      between comparison groups using propensity score inverse probability weighting 
      and assessed associations with Poisson regression modeling. RESULTS: A total of 
      65,418 live births and stillbirths were included, and there were 194 cases with 
      congenital genitourinary defects among them. The prevalence of genitourinary 
      system birth defects was 29.2 (34.9) per 10,000 for FA/MMFA users (nonusers). 
      Compared to nonusers, FA/MMFA users had a lower risk for genitourinary system 
      birth defects (adjusted risk ratio [aRR] 0.81, 95% confidence interval [CI] 0.67, 
      0.98), and for hypospadias (aRR 0.55, 95% CI 0.40, 0.76). CONCLUSIONS: FA or MMFA 
      supplementation during the maternal periconceptional period could reduce the risk 
      for genitourinary system birth defects in offspring. More mechanisms should be 
      explored for the protective effect. IMPACT: Folic acid (FA) or multiple 
      micronutrients containing folic acid (MMFA) supplementation during the maternal 
      periconceptional period could reduce the risk for genitourinary system birth 
      defects in offspring. Maternal FA/MMFA supplementation during the 
      periconceptional period may reduce the risk for hypospadias.
CI  - (c) 2023. The Author(s), under exclusive licence to the International Pediatric 
      Research Foundation, Inc.
FAU - Pang, Zixi
AU  - Pang Z
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing, 100191, China.
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, 100191, China.
FAU - Jin, Lei
AU  - Jin L
AD  - Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, 101100, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing, 100191, China.
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, 100191, China.
FAU - Meng, Wenying
AU  - Meng W
AD  - Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, 101100, China.
FAU - Wang, Di
AU  - Wang D
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing, 100191, China.
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, 100191, China.
FAU - Jin, Lei
AU  - Jin L
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing, 100191, China. jinlei@bjmu.edu.cn.
AD  - Institute of Reproductive and Child Health, National Health Commission Key 
      Laboratory of Reproductive Health, Peking University, Beijing, 100191, China. 
      jinlei@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230915
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Pregnancy
MH  - Male
MH  - Female
MH  - Humans
MH  - *Dietary Supplements
MH  - *Hypospadias
MH  - Folic Acid/therapeutic use
MH  - Prenatal Care
MH  - Urogenital System
EDAT- 2023/09/15 00:42
MHDA- 2024/03/11 06:42
CRDT- 2023/09/14 23:25
PHST- 2023/03/29 00:00 [received]
PHST- 2023/06/14 00:00 [accepted]
PHST- 2023/06/06 00:00 [revised]
PHST- 2024/03/11 06:42 [medline]
PHST- 2023/09/15 00:42 [pubmed]
PHST- 2023/09/14 23:25 [entrez]
AID - 10.1038/s41390-023-02808-7 [pii]
AID - 10.1038/s41390-023-02808-7 [doi]
PST - ppublish
SO  - Pediatr Res. 2024 Mar;95(4):1132-1138. doi: 10.1038/s41390-023-02808-7. Epub 2023 
      Sep 15.