PMID- 37712396
OWN - NLM
STAT- Publisher
LR  - 20230915
IS  - 1764-1489 (Print)
IS  - 1764-1489 (Linking)
DP  - 2023 Sep 15
TI  - Predicting the Outcome of the Buckwheat Oral Challenge Test: A First Evaluation 
      Assuming a Single Serving of Boiled Buckwheat Noodles.
LID - 10.23822/EurAnnACI.1764-1489.315 [doi]
AB  - Background. Global increase in buckwheat consumption has led to a surge in 
      buckwheat allergy reports. However, studies scrutinizing the predictive accuracy 
      of buckwheat-specific immunoglobulin E (IgE) antibody levels in correlation with 
      symptom manifestation remain limited. A critical concern is the discrepancy 
      between the total buckwheat amount featured in prior studies and the quantity 
      consumed per occasion. We aimed to determine open Oral Food Challenge (OFC) 
      positivity rates with buckwheat, using a single serving of boiled buckwheat 
      noodles, and assess the predictability of positive responses using 
      buckwheat-specific IgE levels. Methods. Patients aged 20 years or younger, 
      suspected of buckwheat allergy, were subjected to an OFC involving consumption of 
      100 g (4800 mg of protein) of boiled buckwheat noodles for those under six years, 
      and 200 g (9600 mg of protein) for those six years or older. The predictive 
      accuracy of the OFC, corresponding with buckwheat-specific IgE antibody levels, 
      was evaluated using Receiver Operating Characteristic (ROC) analysis. Results. 
      Our study involved 80 patients who undertook a buckwheat OFC. Among these, 14 
      (17.5%) tested positive for a buckwheat allergy, with 3 (3.8%) developing 
      anaphylaxis. The comparative analysis of buckwheat-specific IgE antibody levels 
      did not offer a reliable predictive measure for OFC outcomes. However, a past 
      history of symptom manifestation following buckwheat consumption was 
      significantly correlated with a positive OFC. Conclusions. Forecasting OFC 
      outcomes based on buckwheat-specific IgE antibody levels poses a challenge, even 
      when taking into account the total quantity of buckwheat that can be consumed in 
      a single occasion.
FAU - Horimukai, K
AU  - Horimukai K
AD  - Department of Pediatrics, Jikei University Katsushika Medical Center, Tokyo, 
      Japan.
FAU - Kinoshita, M
AU  - Kinoshita M
AD  - Department of Pediatrics, Jikei University Katsushika Medical Center, Tokyo, 
      Japan.
FAU - Takahata, N
AU  - Takahata N
AD  - Department of Pediatrics, Jikei University Katsushika Medical Center, Tokyo, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20230915
PL  - Italy
TA  - Eur Ann Allergy Clin Immunol
JT  - European annals of allergy and clinical immunology
JID - 101466614
SB  - IM
OTO - NOTNLM
OT  - Buckwheat hypersensitivity
OT  - child
OT  - oral challenge test
EDAT- 2023/09/15 12:42
MHDA- 2023/09/15 12:42
CRDT- 2023/09/15 06:43
PHST- 2023/09/15 12:42 [medline]
PHST- 2023/09/15 12:42 [pubmed]
PHST- 2023/09/15 06:43 [entrez]
AID - 10.23822/EurAnnACI.1764-1489.315 [doi]
PST - aheadofprint
SO  - Eur Ann Allergy Clin Immunol. 2023 Sep 15. doi: 10.23822/EurAnnACI.1764-1489.315.