PMID- 37712504
OWN - NLM
STAT- Publisher
LR  - 20231003
IS  - 1945-1938 (Electronic)
IS  - 1049-023X (Linking)
VI  - 38
IP  - 5
DP  - 2023 Oct
TI  - Evaluation of Lac and NGAL on the Condition and Prognosis of Patients with Diquat 
      Poisoning.
PG  - 564-569
LID - 10.1017/S1049023X23006350 [doi]
AB  - AIM: This study aims to explore the evaluation of lactic acid (Lac) and 
      neutrophil gelatinase-associated lipocalin (NGAL) on the condition and prognosis 
      of patients with diquat (DQ) poisoning. METHODS: A total of 79 cases of DQ 
      poisoning treated in one hospital from January 2019 through February 2023 were 
      included: 10 cases of mild poisoning, 49 cases of moderate to severe poisoning, 
      and 20 cases of fulminant poisoning. According to the Kidney Disease: Improving 
      Global Outcomes-acute kidney injury (KDIGO-AKI) criteria, the patients were 
      divided into 60 cases in the AKI group and 19 cases in the non-acute kidney 
      injury (NAKI) group. According to the AKI diagnostic indicators, AKI patients 
      were divided into Grade I, Grade II, and Grade III. According to prognosis, the 
      patients were divided into survivor group and non-survivor group. During the same 
      period, 30 healthy subjects were selected as the healthy group. The changes of 
      blood Lac, NGAL, cystatin C (CysC), and serum creatinine (Scr) levels of patients 
      were detected, the 28-day survival of patients was recorded, and the correlation 
      between blood Lac, NGAL levels, and renal injury grade in patients with AKI 
      caused by DQ poisoning was analyzed. The receiver operator characteristic (ROC) 
      curve was used to evaluate the predictive value and prognostic value of Lac, 
      NGAL, and their combination in patients with AKI caused by DQ poisoning. RESULTS: 
      There were significant differences in AKI grade, Lac, NGAL, CysC, and Scr levels 
      among different degrees of poisoning groups (P < .05). There were significant 
      differences in the levels of Lac, NGAL, CysC, and Scr among patients with 
      different AKI grades (P < .05). The levels of Lac, NGAL, CysC, and Scr in the 
      survivor group were significantly lower than those in the non-survivor group (P < 
      .05). The blood Lac and NGAL levels were positively correlated with AKI grades in 
      patients with DQ poisoning (r = 0.752, 0.836; P = .000, .000). The combined 
      detection of blood Lac and NGAL had higher predictive value for AKI and assessed 
      value for death in DQ poisoning than either of them alone. CONCLUSION: The 
      combined detection of Lac and NGAL have a certain clinical value in AKI grading 
      and evaluating AKI prognosis caused by DQ poisoning.
FAU - Zhu, Qianqian
AU  - Zhu Q
AD  - Emergency Department, Harrison International Peace Hospital Affiliated to Hebei 
      Medical University, Hengshui, 053000, China.
FAU - Xu, Wenpin
AU  - Xu W
AD  - Emergency Department, Harrison International Peace Hospital Affiliated to Hebei 
      Medical University, Hengshui, 053000, China.
FAU - Qi, Hongna
AU  - Qi H
AD  - Emergency Department, Harrison International Peace Hospital Affiliated to Hebei 
      Medical University, Hengshui, 053000, China.
FAU - Zhu, Baoyue
AU  - Zhu B
AD  - Emergency Department, Harrison International Peace Hospital Affiliated to Hebei 
      Medical University, Hengshui, 053000, China.
FAU - Wang, Weizhan
AU  - Wang W
AUID- ORCID: 0000-0001-5405-2402
AD  - Emergency Department, Harrison International Peace Hospital Affiliated to Hebei 
      Medical University, Hengshui, 053000, China.
LA  - eng
PT  - Journal Article
DEP - 20230915
PL  - United States
TA  - Prehosp Disaster Med
JT  - Prehospital and disaster medicine
JID - 8918173
OTO - NOTNLM
OT  - acute kidney injury
OT  - cystatin C
OT  - diquat poisoning
OT  - lactic acid
OT  - neutrophil gelatinase-associated lipocalin
EDAT- 2023/09/15 12:43
MHDA- 2023/09/15 12:43
CRDT- 2023/09/15 06:52
PHST- 2023/09/15 12:43 [pubmed]
PHST- 2023/09/15 12:43 [medline]
PHST- 2023/09/15 06:52 [entrez]
AID - S1049023X23006350 [pii]
AID - 10.1017/S1049023X23006350 [doi]
PST - ppublish
SO  - Prehosp Disaster Med. 2023 Oct;38(5):564-569. doi: 10.1017/S1049023X23006350. 
      Epub 2023 Sep 15.