PMID- 37714977
OWN - NLM
STAT- MEDLINE
DCOM- 20231108
LR  - 20240308
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 27
IP  - 11
DP  - 2023 Nov
TI  - Clinical diagnostic value of IL-14, 1L-16 and SAA in periodontitis.
PG  - 6627-6635
LID - 10.1007/s00784-023-05269-8 [doi]
AB  - OBJECTIVES: Periodontitis is a chronic infectious disease, which leads to 
      inflammatory destruction of periodontal supporting tissues. Interleukin 14 
      (IL-14), Interleukin 16 (IL-16) and serum amyloid A (SAA) have been demonstrated 
      to be abnormally expressed in inflammatory diseases. Therefore, this study was 
      performed to analyzed the expression and potential clinical values of IL-14, 
      1L-16 and SAA in periodontitis. MATERIALS AND METHODS: A total of 100 
      periodontitis patients and 100 healthy volunteers were recruited and the saliva 
      and serum samples were collected. Then the C-reactive protein (CRP), 
      procalcitonin (PCT), IL-14, 1L-16 and SAA levels in the saliva and serum of 
      periodontitis patients were measured by Elisa kits. Besides, the significance of 
      CRP, PCT, IL-14, 1L-16 and SAA in periodontitis patients were analyzed by 
      receiver operating characteristic (ROC) analysis. RESULTS: The results showed 
      that CRP, PCT, IL-14, 1L-16 and SAA levels were significantly increased in the 
      the saliva and serum of the periodontitis patients. Additionally, the area under 
      the curve (AUC) of saliva CRP, PCT, IL-14, 1L-16 and SAA for the diagnosis of 
      periodontitis were 0.9035, 0.9435, 0.9508, 0.9500 and 0.9467, respectively. The 
      AUC of serum CRP, PCT, IL-14, 1L-16 and SAA for the diagnosis of periodontitis 
      were 0.9035, 0.9435, 0.9508, 0.9500 and 0.9467, respectively. What's more, the 
      diagnostic value of IL-14, 1L-16 and SAA were enhanced when combining with CRP 
      and PCT. CONCLUSION AND CLINICAL RELEVANCE: This study demonstrated that IL-14, 
      IL-16 and SAA expressions were upregulated in periodontitis patients and 
      exhibited a significant significance for periodontitis diagnosis.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Lu, Xiaomiao
AU  - Lu X
AD  - Department of Stomatology, The First Affiliated Hospital of Bengbu Medical 
      College, No. 287, Changhuai Road, Longzihu District, Bengbu City, 233004, Anhui 
      Province, China.
FAU - Li, Ping
AU  - Li P
AD  - Department of Stomatology, The First Affiliated Hospital of Bengbu Medical 
      College, No. 287, Changhuai Road, Longzihu District, Bengbu City, 233004, Anhui 
      Province, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Stomatology, The First Affiliated Hospital of Bengbu Medical 
      College, No. 287, Changhuai Road, Longzihu District, Bengbu City, 233004, Anhui 
      Province, China.
FAU - Hu, Jie
AU  - Hu J
AD  - Department of Stomatology, The First Affiliated Hospital of Bengbu Medical 
      College, No. 287, Changhuai Road, Longzihu District, Bengbu City, 233004, Anhui 
      Province, China.
FAU - Tian, Ruixue
AU  - Tian R
AD  - Department of Stomatology, The First Affiliated Hospital of Bengbu Medical 
      College, No. 287, Changhuai Road, Longzihu District, Bengbu City, 233004, Anhui 
      Province, China. luxiaomiao1983@163.com.
LA  - eng
GR  - 2021byzd136/Natural Science Research Project of Bengbu Medical College/
GR  - KJ2021A0790/Natural Science Research Project of Anhui Educational Committee/
PT  - Journal Article
DEP - 20230916
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 0 (Serum Amyloid A Protein)
RN  - 9007-12-9 (Calcitonin)
RN  - 0 (Interleukin-16)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Biomarkers)
MH  - Humans
MH  - *Serum Amyloid A Protein/analysis/metabolism
MH  - Calcitonin
MH  - Interleukin-16
MH  - C-Reactive Protein/analysis
MH  - ROC Curve
MH  - *Periodontitis
MH  - Biomarkers
OTO - NOTNLM
OT  - 1L-16
OT  - Diagnosis
OT  - IL-14
OT  - Periodontitis
OT  - SAA
EDAT- 2023/09/16 05:42
MHDA- 2023/11/08 06:44
CRDT- 2023/09/15 23:29
PHST- 2023/07/12 00:00 [received]
PHST- 2023/09/11 00:00 [accepted]
PHST- 2023/11/08 06:44 [medline]
PHST- 2023/09/16 05:42 [pubmed]
PHST- 2023/09/15 23:29 [entrez]
AID - 10.1007/s00784-023-05269-8 [pii]
AID - 10.1007/s00784-023-05269-8 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2023 Nov;27(11):6627-6635. doi: 10.1007/s00784-023-05269-8. 
      Epub 2023 Sep 16.