PMID- 37715904
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 48
DP  - 2023 Oct
TI  - Associations of metal mixtures with thyroid function and potential interactions 
      with iodine status: results from a cross-sectional study in MEWHC.
PG  - 105665-105674
LID - 10.1007/s11356-023-29682-4 [doi]
AB  - Few studies are available on associations between metal mixture exposures and 
      disrupted thyroid hormone homeostasis; particularly, the role of iodine status 
      was ignored. Here, we aimed to explore the cross-sectional relationship of blood 
      cell metals with thyroid homeostasis and explore the potential modifying effect 
      of iodine status. Among 328 workers from the manganese-exposed workers healthy 
      cohort (MEWHC), we detected thyroid function parameters: thyroid stimulating 
      hormone (TSH), total triiodothyronine (TT3), free triiodothyronine (FT3), total 
      tetraiodothyronine (TT4), free tetraiodothyronine (FT4) as well as calculated sum 
      activity of peripheral deiodinases (G(D)) and thyroid's secretory capacity 
      (G(T)). Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure 
      22 metal concentrations in blood cells. Based on the consistent results of least 
      absolute shrinkage and selection operator (LASSO) and Bayesian kernel machine 
      regression (BKMR) analyses, there were significant positive associations between 
      copper and TSH (beta = 2.016), iron and FT4 (beta = 0.403), titanium and G(D) 
      (beta = 0.142), nickel and G(D) (beta = 0.057), and negative associations between 
      copper and FT4 (beta =  - 0.226), selenium and G(D) (beta =  - 0.332), among the 
      participants. Interestingly, we observed an inverted-U shape relationship between 
      magnesium and FT4. Furthermore, we found a synergistic effect between arsenic and 
      copper on the TSH level, while antagonistic effects between nickel and copper as 
      well as nickel and selenium on the TSH level. We observed a modified effect of 
      iodine status on association between strontium and G(D) (P(interaction) = 0.026). 
      It suggests metal mixture exposures can alter thyroid homeostasis among the 
      occupational population, and deiodinase activity had a modified effect on 
      association between strontium and G(D). Validation of these associations and 
      elucidation of underlying mechanisms require further researches in the future.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Ge, Xiaoting
AU  - Ge X
AD  - Department of Public Health, School of Medicine, Guangxi University of Science 
      and Technology, Liuzhou, 545006, China.
FAU - He, Junxiu
AU  - He J
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Lin, Sencai
AU  - Lin S
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Bao, Yu
AU  - Bao Y
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Zheng, Yuan
AU  - Zheng Y
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Cheng, Hong
AU  - Cheng H
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Cai, Haiqing
AU  - Cai H
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Feng, Xiuming
AU  - Feng X
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Yang, Wenjun
AU  - Yang W
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Hu, Sihan
AU  - Hu S
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Wang, Lin
AU  - Wang L
AD  - School of Science, Guangxi University of Science and Technology, Liuzhou, 545006, 
      China.
FAU - Liao, Qijing
AU  - Liao Q
AD  - School of Science, Guangxi University of Science and Technology, Liuzhou, 545006, 
      China.
FAU - Wang, Fei
AU  - Wang F
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Liu, Cahoqun
AU  - Liu C
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Chen, Xing
AU  - Chen X
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Zou, Yunfeng
AU  - Zou Y
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China.
FAU - Yang, Xiaobo
AU  - Yang X
AUID- ORCID: 0000-0001-9866-7724
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning, Guangxi, 530021, China. 
      yangx@gxmu.edu.cn.
LA  - eng
GR  - U21A20340/National Natural Science Foundation of China/
GR  - 82073504/National Natural Science Foundation of China/
GR  - 2023KY0347/Middle-aged and Young Teachers' Basic Ability Promotion Project of 
      Guangxi/
PT  - Journal Article
DEP - 20230916
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 42Z2K6ZL8P (Manganese)
RN  - 789U1901C5 (Copper)
RN  - 9679TC07X4 (Iodine)
RN  - H6241UJ22B (Selenium)
RN  - 7OV03QG267 (Nickel)
RN  - 0 (Metals)
RN  - 9002-71-5 (Thyrotropin)
RN  - YZS2RPE8LE (Strontium)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Humans
MH  - Triiodothyronine
MH  - Thyroid Gland
MH  - Manganese
MH  - Cross-Sectional Studies
MH  - Copper
MH  - *Iodine
MH  - *Selenium
MH  - Nickel
MH  - Bayes Theorem
MH  - Metals
MH  - Thyrotropin
MH  - Strontium
MH  - Thyroxine
OTO - NOTNLM
OT  - Chemical pollution
OT  - Exposure biomarkers
OT  - Hematology
OT  - Iodine
OT  - Thyroid homeostasis
EDAT- 2023/09/16 20:41
MHDA- 2023/10/23 01:18
CRDT- 2023/09/16 11:09
PHST- 2023/04/26 00:00 [received]
PHST- 2023/08/30 00:00 [accepted]
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/09/16 20:41 [pubmed]
PHST- 2023/09/16 11:09 [entrez]
AID - 10.1007/s11356-023-29682-4 [pii]
AID - 10.1007/s11356-023-29682-4 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Oct;30(48):105665-105674. doi: 
      10.1007/s11356-023-29682-4. Epub 2023 Sep 16.