PMID- 37716905
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20231115
IS  - 1471-499X (Electronic)
IS  - 1471-4914 (Linking)
VI  - 29
IP  - 12
DP  - 2023 Dec
TI  - Total recall: the role of PIDDosome components in neurodegeneration.
PG  - 996-1013
LID - S1471-4914(23)00193-4 [pii]
LID - 10.1016/j.molmed.2023.08.008 [doi]
AB  - The PIDDosome is a multiprotein complex that includes p53-induced protein with a 
      death domain 1 (PIDD1), receptor-interacting protein-associated ICH-1/CED-3 
      homologous protein with a death domain (RAIDD), and caspase-2, the activation of 
      which is driven by PIDDosome assembly. In addition to the key role of the 
      PIDDosome in the regulation of cell differentiation, tissue homeostasis, and 
      organogenesis and regeneration, caspase-2, RAIDD and PIDD1 engagement in neuronal 
      development was shown. Here, we focus on the involvement of PIDDosome components 
      in neurodegenerative disorders, including retinal neuropathies, different types 
      of brain damage, and Alzheimer's disease (AD), Huntington's disease (HD), and 
      Lewy body disease. We also discuss pathogenic variants of PIDD1, RAIDD, and 
      caspase-2 that are associated with intellectual, behavioral, and psychological 
      abnormalities, together with prospective PIDDosome inhibition strategies and 
      their potential clinical application.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Volik, Pavel I
AU  - Volik PI
AD  - Facuty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; 
      Engelhardt Institute of Molecular Biology, RAS, 119991 Moscow, Russia.
FAU - Kopeina, Gelina S
AU  - Kopeina GS
AD  - Facuty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; 
      Engelhardt Institute of Molecular Biology, RAS, 119991 Moscow, Russia.
FAU - Zhivotovsky, Boris
AU  - Zhivotovsky B
AD  - Facuty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; 
      Engelhardt Institute of Molecular Biology, RAS, 119991 Moscow, Russia; Division 
      of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 
      210, 17177 Stockholm, Sweden. Electronic address: boris.zhivotovsky@ki.se.
FAU - Zamaraev, Alexey V
AU  - Zamaraev AV
AD  - Facuty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; 
      Engelhardt Institute of Molecular Biology, RAS, 119991 Moscow, Russia. Electronic 
      address: a-zamaraev@yandex.ru.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230914
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - 0 (Death Domain Receptor Signaling Adaptor Proteins)
RN  - 0 (CRADD Signaling Adaptor Protein)
RN  - EC 3.4.22.- (Caspase 2)
SB  - IM
MH  - Humans
MH  - *Death Domain Receptor Signaling Adaptor Proteins/genetics/metabolism
MH  - *CRADD Signaling Adaptor Protein/metabolism
MH  - Caspase 2/genetics/metabolism
MH  - Prospective Studies
MH  - Apoptosis/physiology
OTO - NOTNLM
OT  - PIDD1
OT  - PIDDosome
OT  - RAIDD
OT  - caspase-2
OT  - cell death
OT  - neurodegeneration
COIS- Declaration of Interests The authors declare no competing interests.
EDAT- 2023/09/17 00:41
MHDA- 2023/11/13 06:42
CRDT- 2023/09/16 21:57
PHST- 2023/07/12 00:00 [received]
PHST- 2023/08/23 00:00 [revised]
PHST- 2023/08/25 00:00 [accepted]
PHST- 2023/11/13 06:42 [medline]
PHST- 2023/09/17 00:41 [pubmed]
PHST- 2023/09/16 21:57 [entrez]
AID - S1471-4914(23)00193-4 [pii]
AID - 10.1016/j.molmed.2023.08.008 [doi]
PST - ppublish
SO  - Trends Mol Med. 2023 Dec;29(12):996-1013. doi: 10.1016/j.molmed.2023.08.008. Epub 
      2023 Sep 14.