PMID- 37717025
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240106
IS  - 2754-6993 (Electronic)
IS  - 2754-6993 (Linking)
VI  - 9
IP  - 1
DP  - 2023 Sep 16
TI  - Speech characteristics yield important clues about motor function: Speech 
      variability in individuals at clinical high-risk for psychosis.
PG  - 60
LID - 10.1038/s41537-023-00382-9 [doi]
LID - 60
AB  - BACKGROUND AND HYPOTHESIS: Motor abnormalities are predictive of psychosis onset 
      in individuals at clinical high risk (CHR) for psychosis and are tied to its 
      progression. We hypothesize that these motor abnormalities also disrupt their 
      speech production (a highly complex motor behavior) and predict CHR individuals 
      will produce more variable speech than healthy controls, and that this 
      variability will relate to symptom severity, motor measures, and psychosis-risk 
      calculator risk scores. STUDY DESIGN: We measure variability in speech production 
      (variability in consonants, vowels, speech rate, and pausing/timing) in N = 58 
      CHR participants and N = 67 healthy controls. Three different tasks are used to 
      elicit speech: diadochokinetic speech (rapidly-repeated syllables e.g., papapa..., 
      pataka...), read speech, and spontaneously-generated speech. STUDY RESULTS: 
      Individuals in the CHR group produced more variable consonants and exhibited 
      greater speech rate variability than healthy controls in two of the three speech 
      tasks (diadochokinetic and read speech). While there were no significant 
      correlations between speech measures and remotely-obtained motor measures, 
      symptom severity, or conversion risk scores, these comparisons may be 
      under-powered (in part due to challenges of remote data collection during the 
      COVID-19 pandemic). CONCLUSION: This study provides a thorough and theory-driven 
      first look at how speech production is affected in this at-risk population and 
      speaks to the promise and challenges facing this approach moving forward.
CI  - (c) 2023. Springer Nature Limited.
FAU - Hitczenko, Kasia
AU  - Hitczenko K
AD  - Laboratoire de Sciences Cognitives et Psycholinguistique, Departement d'Etudes 
      Cognitives, ENS, EHESS, CNRS, PSL University, Paris, France. 
      kasia.hitczenko@ens.psl.eu.
FAU - Segal, Yael
AU  - Segal Y
AD  - Faculty of Electrical and Computer Engineering, Technion-Israel Institute of 
      Technology, Haifa, Israel.
FAU - Keshet, Joseph
AU  - Keshet J
AUID- ORCID: 0000-0003-2332-5783
AD  - Faculty of Electrical and Computer Engineering, Technion-Israel Institute of 
      Technology, Haifa, Israel.
FAU - Goldrick, Matthew
AU  - Goldrick M
AD  - Department of Linguistics, Northwestern University, Evanston, IL, USA.
AD  - Department of Psychology, Northwestern University, Evanston, IL, USA.
AD  - Cognitive Science Program, Northwestern University, Evanston, IL, USA.
AD  - Institute for Policy Research, Northwestern University, Evanston, IL, USA.
FAU - Mittal, Vijay A
AU  - Mittal VA
AUID- ORCID: 0000-0001-9017-5119
AD  - Department of Psychology, Northwestern University, Evanston, IL, USA.
AD  - Cognitive Science Program, Northwestern University, Evanston, IL, USA.
AD  - Institute for Policy Research, Northwestern University, Evanston, IL, USA.
AD  - Department of Psychiatry, Northwestern University, Evanston, IL, USA.
AD  - Medical Social Sciences, Northwestern University, Chicago, IL, USA.
AD  - Institute for Innovations in Developmental Sciences, Evanston/Chicago, IL, USA.
LA  - eng
GR  - R21 MH119677/MH/NIMH NIH HHS/United States
GR  - T32 NS047987/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20230916
PL  - Germany
TA  - Schizophrenia (Heidelb)
JT  - Schizophrenia (Heidelberg, Germany)
JID - 9918367987006676
PMC - PMC10505148
COIS- The authors declare no competing interests.
EDAT- 2023/09/17 00:41
MHDA- 2023/09/17 00:42
PMCR- 2023/09/16
CRDT- 2023/09/16 23:24
PHST- 2023/04/19 00:00 [received]
PHST- 2023/07/24 00:00 [accepted]
PHST- 2023/09/17 00:42 [medline]
PHST- 2023/09/17 00:41 [pubmed]
PHST- 2023/09/16 23:24 [entrez]
PHST- 2023/09/16 00:00 [pmc-release]
AID - 10.1038/s41537-023-00382-9 [pii]
AID - 382 [pii]
AID - 10.1038/s41537-023-00382-9 [doi]
PST - epublish
SO  - Schizophrenia (Heidelb). 2023 Sep 16;9(1):60. doi: 10.1038/s41537-023-00382-9.