PMID- 37717230
OWN - NLM
STAT- MEDLINE
DCOM- 20240209
LR  - 20240210
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Print)
IS  - 1861-0684 (Linking)
VI  - 113
IP  - 2
DP  - 2024 Feb
TI  - Treatment of patients with multiple organ dysfunction syndrome (MODS) with an 
      electromagnetic field coupled to biorhythmically defined impulse configuration: 
      the MicrocircMODS study.
PG  - 260-275
LID - 10.1007/s00392-023-02293-2 [doi]
AB  - BACKGROUND: To potentially improve impaired vasomotion of patients with multiple 
      organ dysfunction syndrome (MODS), we tested whether an electromagnetic field of 
      low flux density coupled with a biorhythmically defined impulse configuration 
      (Physical Vascular Therapy BEMER((R)), PVT), in addition to standard care, is safe 
      and feasible and might improve disturbed microcirculatory blood flow and thereby 
      improve global haemodynamics. METHODS: In a prospective, monocentric, one-arm 
      pilot study, 10 MODS patients (APACHE II score 20-35) were included. Patients 
      were treated, in addition to standard care, for 4 days with PVT (3 treatment 
      periods of 8 min each day; day 1: field intensity 10.5 muT; day 2:14 muT, day 
      3:17.5 muT; day 4:21.0 muT). Primary endpoint was the effect of PVT on sublingual 
      microcirculatory perfusion, documented by microvascular flow index (MFI). Patient 
      safety, adverse events, and outcomes were documented. RESULTS: An increase in MFI 
      by approximately 25% paralleled 4-day PVT, with the increase starting immediately 
      after the first PVT and lasting over the total 4-day treatment period. Concerning 
      global haemodynamics (secondary endpoints), halving vasopressor use within 24 h, 
      and haemodynamic stabilisation paralleled 4-day PVT with an increase in cardiac 
      index, stroke volume index, and cardiac power index by 30%-50%. No adverse events 
      (AEs) or serious adverse events (SAEs) were classified as causally related to the 
      medical product (PVT) or study. Three patients died within 28 days and one 
      patient between 28 and 180 days. CONCLUSION: PVT treatment was feasible and safe 
      and could be performed without obstruction of standard patient care. An increase 
      in microcirculatory blood flow, a rapid reduction in vasopressor use, and an 
      improvement in global haemodynamics paralleled PVT treatment. Findings of this 
      pilot study allowed forming a concept for a randomized trial for further proof.
CI  - (c) 2023. The Author(s).
FAU - Werdan, Karl
AU  - Werdan K
AUID- ORCID: 0000-0001-8137-2938
AD  - Department of Internal Medicine III, University Hospital Halle (Saale), 
      Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097, Halle 
      (Saale), Germany. karl.werdan@medizin.uni-halle.de.
FAU - Nuding, Sebastian
AU  - Nuding S
AD  - Department of Internal Medicine III, University Hospital Halle (Saale), 
      Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097, Halle 
      (Saale), Germany.
AD  - Hospital St. Elisabeth and St. Barbara, 06110, Halle (Saale), Germany.
FAU - Kuhnert, Diethelm
AU  - Kuhnert D
AD  - Department of Internal Medicine III, University Hospital Halle (Saale), 
      Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097, Halle 
      (Saale), Germany.
AD  - , 04838, Zschepplin, Germany.
FAU - Kolthoum, Ramzi
AU  - Kolthoum R
AD  - Department of Internal Medicine III, University Hospital Halle (Saale), 
      Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097, Halle 
      (Saale), Germany.
FAU - Schott, Artjom
AU  - Schott A
AD  - Department of Internal Medicine III, University Hospital Halle (Saale), 
      Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097, Halle 
      (Saale), Germany.
FAU - Quitter, Felix
AU  - Quitter F
AD  - , 01277, Dresden, Germany.
FAU - Wienke, Andreas
AU  - Wienke A
AD  - Institute of Medical Epidemiology, Biometry and Computer Science, 
      Martin-Luther-University Halle-Wittenberg, Magdeburger Strasse 8, 06112, Halle 
      (Saale), Germany.
FAU - Sedding, Daniel
AU  - Sedding D
AD  - Department of Internal Medicine III, University Hospital Halle (Saale), 
      Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097, Halle 
      (Saale), Germany.
LA  - eng
GR  - KKSH-120/BEMER Int, Triesen, Liechtenstein/
PT  - Journal Article
DEP - 20230917
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Humans
MH  - *Multiple Organ Failure/therapy
MH  - Microcirculation/physiology
MH  - Prospective Studies
MH  - *Electromagnetic Fields
MH  - Pilot Projects
PMC - PMC10850207
OTO - NOTNLM
OT  - Electromagnetic field
OT  - Loss of haemodynamic coherence
OT  - Microcirculation
OT  - Multiple organ dysfunction syndrome (MODS)
OT  - Physical Vascular Therapy BEMER(R) (PVT)
COIS- KW received financial support for congress attendance from BEMER Int. All other 
      authors have disclosed that they do not have any conflicts of interest.
EDAT- 2023/09/17 18:42
MHDA- 2024/02/09 06:42
PMCR- 2023/09/17
CRDT- 2023/09/17 14:50
PHST- 2023/04/30 00:00 [received]
PHST- 2023/08/21 00:00 [accepted]
PHST- 2024/02/09 06:42 [medline]
PHST- 2023/09/17 18:42 [pubmed]
PHST- 2023/09/17 14:50 [entrez]
PHST- 2023/09/17 00:00 [pmc-release]
AID - 10.1007/s00392-023-02293-2 [pii]
AID - 2293 [pii]
AID - 10.1007/s00392-023-02293-2 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2024 Feb;113(2):260-275. doi: 10.1007/s00392-023-02293-2. Epub 
      2023 Sep 17.