PMID- 37718634 OWN - NLM STAT- MEDLINE DCOM- 20231107 LR - 20231115 IS - 1759-7714 (Electronic) IS - 1759-7706 (Print) IS - 1759-7706 (Linking) VI - 14 IP - 31 DP - 2023 Nov TI - Expert consensus on the diagnosis and treatment of RET gene fusion non-small cell lung cancer in China. PG - 3166-3177 LID - 10.1111/1759-7714.15105 [doi] AB - The rearranged during transfection (RET) gene is one of the receptor tyrosine kinases and cell-surface molecules responsible for transmitting signals that regulate cell growth and differentiation. In non-small cell lung cancer (NSCLC), RET fusion is a rare driver gene alteration associated with a poor prognosis. Fortunately, two selective RET inhibitors (sRETi), namely pralsetinib and selpercatinib, have been approved for treating RET fusion NSCLC due to their remarkable efficacy and safety profiles. These inhibitors have shown the ability to overcome resistance to multikinase inhibitors (MKIs). Furthermore, ongoing clinical trials are investigating several second-generation sRETis that are specifically designed to target solvent front mutations, which pose a challenge for first-generation sRETis. The effective screening of patients is the first crucial step in the clinical application of RET-targeted therapy. Currently, four methods are widely used for detecting gene rearrangements: next-generation sequencing (NGS), reverse transcription-polymerase chain reaction (RT-PCR), fluorescence in situ hybridization (FISH), and immunohistochemistry (IHC). Each of these methods has its advantages and limitations. To streamline the clinical workflow and improve diagnostic and treatment strategies for RET fusion NSCLC, our expert group has reached a consensus. Our objective is to maximize the clinical benefit for patients and promote standardized approaches to RET fusion screening and therapy. CI - (c) 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. FAU - Pu, Xingxiang AU - Pu X AD - The Second Department of Thoracic Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Central South University, Changsha, People's Republic of China. FAU - Xu, Chunwei AU - Xu C AUID- ORCID: 0000-0002-9021-6731 AD - Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, People's Republic of China. AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Wang, Qian AU - Wang Q AD - Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People's Republic of China. FAU - Wang, Wenxian AU - Wang W AUID- ORCID: 0000-0002-3047-4149 AD - Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China. FAU - Wu, Fang AU - Wu F AUID- ORCID: 0000-0002-6627-3437 AD - Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China. FAU - Cai, Xiuyu AU - Cai X AD - Department of VIP Inpatient, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. FAU - Song, Zhengbo AU - Song Z AUID- ORCID: 0000-0002-4817-7775 AD - Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China. FAU - Yu, Jinpu AU - Yu J AD - Department of Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China. FAU - Zhong, Wenzhao AU - Zhong W AUID- ORCID: 0000-0002-8917-8635 AD - Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou, People's Republic of China. FAU - Wang, Zhijie AU - Wang Z AD - State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. 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FAU - Li, Wen AU - Li W AD - Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou, People's Republic of China. FAU - Zhan, Ping AU - Zhan P AUID- ORCID: 0009-0001-3030-2662 AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Liu, Hongbing AU - Liu H AUID- ORCID: 0000-0003-1404-0647 AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Lv, Tangfeng AU - Lv T AUID- ORCID: 0000-0001-7224-8468 AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Miao, Liyun AU - Miao L AUID- ORCID: 0000-0001-9586-3244 AD - Department of Respiratory Medicine, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Min, Lingfeng AU - Min L AD - Department of Respiratory Medicine, Clinical Medical School of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, People's Republic of China. FAU - Lin, Gen AU - Lin G AUID- ORCID: 0000-0001-9411-5519 AD - Department of Medical Oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou, People's Republic of China. FAU - Huang, Long AU - Huang L AUID- ORCID: 0000-0003-4925-5162 AD - Department of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China. FAU - Yuan, Jingping AU - Yuan J AD - Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China. FAU - Jiang, Zhansheng AU - Jiang Z AUID- ORCID: 0000-0002-5707-5148 AD - Department of Integrative Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China. FAU - Rao, Chuangzhou AU - Rao C AD - Department of Radiotherapy and Chemotherapy, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, People's Republic of China. FAU - Lv, Dongqing AU - Lv D AD - Department of Pulmonary Medicine, Taizhou Hospital of Wenzhou Medical University, Taizhou, People's Republic of China. FAU - Yu, Zongyang AU - Yu Z AD - Department of Respiratory Medicine, the 900th Hospital of the Joint Logistics Team (the Former Fuzhou General Hospital), Fujian Medical University, Fuzhou, People's Republic of China. FAU - Li, Xiaoyan AU - Li X AD - Department of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China. FAU - Tang, Chuanhao AU - Tang C AD - Department of Medical Oncology, Peking University International Hospital, Beijing, People's Republic of China. FAU - Zhou, Chengzhi AU - Zhou C AUID- ORCID: 0000-0003-0029-6879 AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease; Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University (The First Affiliated Hospital of Guangzhou Medical University), Guangzhou, People's Republic of China. FAU - Zhang, Junping AU - Zhang J AD - Department of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan, People's Republic of China. FAU - Guo, Hui AU - Guo H AD - Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China. FAU - Chu, Qian AU - Chu Q AD - Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. FAU - Meng, Rui AU - Meng R AD - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. FAU - Liu, Xuewen AU - Liu X AD - Department of Oncology, the Third Xiangya Hospital, Central South University, Changsha, People's Republic of China. FAU - Wu, Jingxun AU - Wu J AD - Department of Medical Oncology, the First Affiliated Hospital of Medicine, Xiamen University, Xiamen, People's Republic of China. FAU - Zhou, Jin AU - Zhou J AD - Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology, Chengdu, People's Republic of China. FAU - Zhu, Zhengfei AU - Zhu Z AUID- ORCID: 0000-0001-7537-3619 AD - Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. FAU - Pan, Weiwei AU - Pan W AD - Department of Cell Biology, College of Medicine, Jiaxing University, Jiaxing, People's Republic of China. FAU - Pang, Fei AU - Pang F AD - Department of Medical, Shanghai OrigiMed Co, Ltd, Shanghai, People's Republic of China. FAU - Huang, Jintao AU - Huang J AD - Department of Medical, Shanghai OrigiMed Co, Ltd, Shanghai, People's Republic of China. FAU - Wang, Kai AU - Wang K AD - Department of Medical, Shanghai OrigiMed Co, Ltd, Shanghai, People's Republic of China. FAU - Wu, Fan AU - Wu F AD - Department of Medical, Menarini Silicon Biosystems Spa, Shanghai, People's Republic of China. FAU - Shen, Tingting AU - Shen T AD - Department of Medical, Stone Pharmaceuticals (Suzhou) Co., Ltd., Shanghai, People's Republic of China. FAU - Zou, Shirui AU - Zou S AD - Department of Medical, Stone Pharmaceuticals (Suzhou) Co., Ltd., Shanghai, People's Republic of China. FAU - Xu, Bingwei AU - Xu B AD - Department of Biotherapy, Cancer Institute, First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China. FAU - Wang, Liping AU - Wang L AD - Department of Oncology, Baotou Cancer Hospital, Baotou, People's Republic of China. FAU - Zhu, Youcai AU - Zhu Y AD - Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing, People's Republic of China. FAU - Lin, Xinqing AU - Lin X AUID- ORCID: 0000-0001-9436-2229 AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease; Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University (The First Affiliated Hospital of Guangzhou Medical University), Guangzhou, People's Republic of China. FAU - Cai, Jing AU - Cai J AUID- ORCID: 0000-0002-6792-4959 AD - Department of Oncology, Second Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China. FAU - Xu, Ling AU - Xu L AD - Department of Interventional Pulmonary Diseases, Anhui Chest Hospital, Hefei, People's Republic of China. FAU - Li, Jisheng AU - Li J AUID- ORCID: 0000-0002-4186-6228 AD - Department of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinnan, People's Republic of China. FAU - Jiao, Xiaodong AU - Jiao X AD - Department of Medical Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, People's Republic of China. FAU - Li, Kainan AU - Li K AD - Department of Oncology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China. FAU - Feng, Huijing AU - Feng H AD - Department of Thoracic Oncology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan, People's Republic of China. FAU - Wang, Lin AU - Wang L AD - Department of Pathology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan, People's Republic of China. FAU - Du, Yingying AU - Du Y AUID- ORCID: 0000-0002-5149-4632 AD - Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China. FAU - Yao, Wang AU - Yao W AD - Department of Interventional Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China. FAU - Shi, Xuefei AU - Shi X AD - Department of Respiratory Medicine, Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, People's Republic of China. FAU - Niu, Xiaomin AU - Niu X AD - Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China. FAU - Yuan, Dongmei AU - Yuan D AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Yao, Yanwen AU - Yao Y AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Kang, Jing AU - Kang J AD - Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou, People's Republic of China. FAU - Zhang, Jiatao AU - Zhang J AD - Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou, People's Republic of China. FAU - Zhang, Chao AU - Zhang C AD - Guangdong Lung Cancer Institute, Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, Guangzhou, People's Republic of China. FAU - Fu, Jianfei AU - Fu J AD - Department of Medical Oncology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People's Republic of China. FAU - Huang, Jianhui AU - Huang J AD - Department of Oncology, Lishui Municipal Central Hospital, Lishui, People's Republic of China. FAU - Zhang, Yinbin AU - Zhang Y AD - Department of Oncology, the Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, People's Republic of China. FAU - Sun, Pingli AU - Sun P AD - Department of Pathology, The Second Hospital of Jilin University, Changchun, People's Republic of China. FAU - Wang, Hong AU - Wang H AD - Senior Department of Oncology, The 5th Medical Center of PLA General Hospital, Beijing, People's Republic of China. FAU - Ye, Mingxiang AU - Ye M AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Wang, Dong AU - Wang D AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Wang, Zhaofeng AU - Wang Z AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Hao, Yue AU - Hao Y AUID- ORCID: 0000-0002-4725-6084 AD - Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China. FAU - Wang, Zhen AU - Wang Z AD - Department of Radiation Oncology, Affiliated Jinling Hospital, Medical School of Nanjing, Nanjing, People's Republic of China. FAU - Wan, Bing AU - Wan B AD - Department of Respiratory Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, People's Republic of China. FAU - Lv, Donglai AU - Lv D AUID- ORCID: 0000-0002-3816-6319 AD - Department of Clinical Oncology, The 901 Hospital of Joint Logistics Support Force of People Liberation Army, Hefei, People's Republic of China. FAU - Lan, Gang AU - Lan G AD - Department of Thoracic Disease Diagnosis and Treatment Center, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing, People's Republic of China. FAU - Yang, Shengjie AU - Yang S AD - Department of Thoracic Surgery, Chuxiong Yi Autonomous Prefecture People's Hospital, Chuxiong, People's Republic of China. FAU - Shi, Lin AU - Shi L AD - Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China. FAU - Wang, Yina AU - Wang Y AD - Department of Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China. FAU - Li, Bihui AU - Li B AD - Department of Oncology, The Second Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China. FAU - Zhang, Zhang AU - Zhang Z AD - International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou, People's Republic of China. FAU - Li, Zhongwu AU - Li Z AD - Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, People's Republic of China. FAU - Li, Yuan AU - Li Y AD - Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. FAU - Liu, Zhefeng AU - Liu Z AD - Senior Department of Oncology, The 5th Medical Center of PLA General Hospital, Beijing, People's Republic of China. FAU - Yang, Nong AU - Yang N AD - Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People's Republic of China. FAU - Wang, Huijuan AU - Wang H AD - Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, People's Republic of China. FAU - Huang, Wenbin AU - Huang W AD - Department of Pathology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, People's Republic of China. FAU - Hong, Zhuan AU - Hong Z AD - Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, People's Republic of China. FAU - Wang, Guansong AU - Wang G AD - Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China. FAU - Wang, Jiandong AU - Wang J AD - Department of Pathology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Fang, Meiyu AU - Fang M AD - Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China. FAU - Fang, Yong AU - Fang Y AD - Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China. FAU - Zhu, Xixu AU - Zhu X AD - Department of Radiation Oncology, Affiliated Jinling Hospital, Medical School of Nanjing, Nanjing, People's Republic of China. FAU - Shen, Yi AU - Shen Y AUID- ORCID: 0000-0002-2144-882X AD - Department of Thoracic Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Zhang, Yiping AU - Zhang Y AD - Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, People's Republic of China. FAU - Ma, Shenglin AU - Ma S AD - Department of Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou Cancer Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou, People's Republic of China. FAU - Song, Yong AU - Song Y AUID- ORCID: 0000-0003-4979-4131 AD - Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. FAU - Lu, Yuanzhi AU - Lu Y AUID- ORCID: 0000-0003-2946-643X AD - Department of Clinical Pathology, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China. FAU - Fang, Wenfeng AU - Fang W AD - Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. FAU - Li, Ziming AU - Li Z AD - Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China. FAU - Wu, Lin AU - Wu L AD - The Second Department of Thoracic Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Central South University, Changsha, People's Republic of China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230918 PL - Singapore TA - Thorac Cancer JT - Thoracic cancer JID - 101531441 RN - EC 2.7.10.1 (Proto-Oncogene Proteins c-ret) RN - EC 2.7.10.1 (RET protein, human) SB - IM MH - Humans MH - *Carcinoma, Non-Small-Cell Lung/diagnosis/drug therapy/genetics MH - *Lung Neoplasms/diagnosis/drug therapy/genetics MH - In Situ Hybridization, Fluorescence MH - Consensus MH - Proto-Oncogene Proteins c-ret/genetics MH - Gene Fusion PMC - PMC10626248 OTO - NOTNLM OT - NSCLC OT - RET fusion OT - precision medicine OT - targeted therapy OT - tyrosine receptor kinase COIS- There are no conflicts of interest to disclose. EDAT- 2023/09/18 06:42 MHDA- 2023/11/07 06:46 PMCR- 2023/09/18 CRDT- 2023/09/18 03:34 PHST- 2023/08/23 00:00 [received] PHST- 2023/08/29 00:00 [accepted] PHST- 2023/11/07 06:46 [medline] PHST- 2023/09/18 06:42 [pubmed] PHST- 2023/09/18 03:34 [entrez] PHST- 2023/09/18 00:00 [pmc-release] AID - TCA15105 [pii] AID - 10.1111/1759-7714.15105 [doi] PST - ppublish SO - Thorac Cancer. 2023 Nov;14(31):3166-3177. doi: 10.1111/1759-7714.15105. Epub 2023 Sep 18.