PMID- 37719677
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Print)
IS  - 2049-9434 (Linking)
VI  - 19
IP  - 4
DP  - 2023 Oct
TI  - Serum vitamin D status in a cohort of infants with food protein‑induced 
      gastrointestinal disease.
PG  - 71
LID - 10.3892/br.2023.1653 [doi]
LID - 71
AB  - Increases in the prevalence of food allergy and vitamin D deficiency have been 
      observed in recent years. The association between vitamin D levels and food 
      allergy remains to be fully elucidated, and research focused on the prevalence of 
      vitamin D insufficiency in infants with food protein-induced gastrointestinal 
      disease in Chengdu, Sichuan is lacking. Thus, the present study aimed to 
      determine the prevalence and clinical characteristics of serum 25 hydroxyvitamin 
      D [25-(OH)D] insufficiency and sufficiency in infants with food protein-induced 
      gastrointestinal disease. The present study also aimed to identify the potential 
      predisposing factors of 25-(OH)D insufficiency. The present retrospective study 
      analyzed data obtained from Chengdu Women's and Children's Central Hospital 
      spanning between June 2021 and February 2022. Children with a confirmed diagnosis 
      of food protein-induced gastrointestinal disease were enrolled in the present 
      study. Blood indicators, including serum 25-(OH)D, serum total immunoglobulin E 
      (IgE), specific IgE against allergens, and hemoglobin were measured during the 
      course of the disease. Clinical characteristics of patients and blood examination 
      results were obtained from the hospital electronic database. A total of 361 
      patients were included in the study group and 45 healthy individuals were 
      included in the control group. The results of the present study demonstrated that 
      serum 25-(OH)D levels of infants with protein-induced gastrointestinal disease 
      were significantly lower compared with the control group. Notably, female 
      participants with higher serum total IgE levels exhibited insufficient serum 
      25-(OH)D levels. However, the results of the logistic regression analysis 
      revealed no predisposing factors associated with serum 25-(OH)D insufficiency. In 
      conclusion, infants with food protein-induced gastrointestinal disease may 
      exhibit a higher risk of low serum 25-(OH)D levels and this risk may be greater 
      in females with higher total IgE.
CI  - Copyright: (c) Zhou et al.
FAU - Zhou, Meng-Yao
AU  - Zhou MY
AD  - Department of Pediatric Infection and Gastroenterology, Chengdu Women and 
      Children's Central Hospital, School of Medicine, University of Electronic Science 
      and Technology, Chengdu, Sichuan 611731, P.R. China.
FAU - Li, Xin
AU  - Li X
AD  - Department of Pediatric, University of Electronic Science and Technology, 
      Chengdu, Sichuan 610000, P.R. China.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Pediatric Infection and Gastroenterology, Chengdu Women and 
      Children's Central Hospital, School of Medicine, University of Electronic Science 
      and Technology, Chengdu, Sichuan 611731, P.R. China.
FAU - Xiong, Li-Jing
AU  - Xiong LJ
AD  - Department of Pediatric Healthcare, Chengdu Women and Children's Central 
      Hospital, School of Medicine, University of Electronic Science and Technology, 
      Chengdu, Sichuan 611731, P.R. China.
FAU - He, Xiao-Qing
AU  - He XQ
AD  - Department of Pediatric Infection and Gastroenterology, Chengdu Women and 
      Children's Central Hospital, School of Medicine, University of Electronic Science 
      and Technology, Chengdu, Sichuan 611731, P.R. China.
FAU - He, Xiao-Qing
AU  - He XQ
AD  - Department of Pediatric Infection and Gastroenterology, Chengdu Women and 
      Children's Central Hospital, School of Medicine, University of Electronic Science 
      and Technology, Chengdu, Sichuan 611731, P.R. China.
FAU - Xie, Xiao-Li
AU  - Xie XL
AD  - Department of Pediatric Infection and Gastroenterology, Chengdu Women and 
      Children's Central Hospital, School of Medicine, University of Electronic Science 
      and Technology, Chengdu, Sichuan 611731, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20230830
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC10502572
OTO - NOTNLM
OT  - 25 hydroxy-vitamin D
OT  - gastrointestinal food allergy
OT  - immunoglobulin E
OT  - pediatrics
OT  - vitamin D
COIS- The authors declare that they have no competing interests.
EDAT- 2023/09/18 06:42
MHDA- 2023/09/18 06:43
PMCR- 2023/08/30
CRDT- 2023/09/18 04:25
PHST- 2023/05/15 00:00 [received]
PHST- 2023/08/08 00:00 [accepted]
PHST- 2023/09/18 06:43 [medline]
PHST- 2023/09/18 06:42 [pubmed]
PHST- 2023/09/18 04:25 [entrez]
PHST- 2023/08/30 00:00 [pmc-release]
AID - BR-19-4-01653 [pii]
AID - 10.3892/br.2023.1653 [doi]
PST - epublish
SO  - Biomed Rep. 2023 Aug 30;19(4):71. doi: 10.3892/br.2023.1653. eCollection 2023 
      Oct.