PMID- 37720378
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 10
DP  - 2023
TI  - Effect of viscous soluble dietary fiber on glucose and lipid metabolism in 
      patients with type 2 diabetes mellitus: a systematic review and meta-analysis on 
      randomized clinical trials.
PG  - 1253312
LID - 10.3389/fnut.2023.1253312 [doi]
LID - 1253312
AB  - BACKGROUND: The effect of viscous soluble dietary fiber on glucose and lipid 
      metabolism in type 2 diabetes mellitus (T2DM) remains controversial, and the 
      dose-response relationship of its effect on blood glucose and blood lipid level 
      is still unclear. METHODS: We conducted comprehensive searches in several 
      databases up to 17 January 2023. We conducted a dose-response analysis of 
      randomized controlled trials (RCTs) to investigate the effect of viscous dietary 
      fiber on glucose and lipid metabolism in patients with T2DM. RESULTS: Statistical 
      significance was observed in the decreases of glycosylated hemoglobin (HbA1c) 
      (mean difference) [MD = -0.47; 95%CI: (-0.66, -0.27)], fasting blood glucose 
      (FBG) [MD = -0.93; 95%CI: (-1.46, -0.41)], total cholesterol (TC) [MD = -0.33; 
      95%CI: (-0.46, -0.21)], and low-density lipoprotein and cholesterol (LDL-C) [MD = 
      -0.24; 95%CI: (-0.35, -0.13)]. Contrarily, no difference was observed regarding 
      the level of high-density lipoprotein cholesterol (HDL-C) or triglyceride (TG). 
      In addition, the effect on fasting insulin remains unclear. Results from the 
      subgroup analyses showed that an intervention duration longer than 6 weeks had a 
      significant effect on the HbA1c level; a treatment dosage higher than 8.3 g/day 
      had a significant effect on the FBG level. CONCLUSIONS: Supplementation of 
      viscous dietary fiber is beneficial to control blood glucose and blood lipid in 
      T2DM.
CI  - Copyright (c) 2023 Lu, Yu, Cao, Xia, Wang, Sun, Chen and Liao.
FAU - Lu, Kun
AU  - Lu K
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, China.
FAU - Yu, Tingqing
AU  - Yu T
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, China.
FAU - Cao, Xinyi
AU  - Cao X
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, China.
FAU - Xia, Hui
AU  - Xia H
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, China.
FAU - Wang, Shaokang
AU  - Wang S
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, China.
FAU - Sun, Guiju
AU  - Sun G
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, China.
FAU - Chen, Liang
AU  - Chen L
AD  - Public Service Platform of South China Sea for R&D Marine Biomedicine Resources, 
      The Marine Biomedical Research Institute, Guangdong Medical University, 
      Zhanjiang, Guangdong, China.
FAU - Liao, Wang
AU  - Liao W
AD  - Key Laboratory of Environmental Medicine and Engineering of Ministry of 
      Education, Department of Nutrition and Food Hygiene, School of Public Health, 
      Southeast University, Nanjing, China.
LA  - eng
PT  - Systematic Review
DEP - 20230831
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC10500602
OTO - NOTNLM
OT  - RCTs
OT  - blood glucose
OT  - blood lipid
OT  - glucose and lipid metabolism
OT  - meta-analysis
OT  - viscous soluble dietary fiber
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/09/18 06:41
MHDA- 2023/09/18 06:42
PMCR- 2023/01/01
CRDT- 2023/09/18 04:39
PHST- 2023/07/05 00:00 [received]
PHST- 2023/08/08 00:00 [accepted]
PHST- 2023/09/18 06:42 [medline]
PHST- 2023/09/18 06:41 [pubmed]
PHST- 2023/09/18 04:39 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2023.1253312 [doi]
PST - epublish
SO  - Front Nutr. 2023 Aug 31;10:1253312. doi: 10.3389/fnut.2023.1253312. eCollection 
      2023.