PMID- 37720405
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 1011-6842 (Print)
IS  - 1011-6842 (Linking)
VI  - 39
IP  - 5
DP  - 2023 Sep
TI  - Effect of Limb Salvage by Excimer Laser Angioplasty Plus Low-Pressure Balloon 
      Inflation in Chronic Limb-Threatening Ischemia Patients with Infrapopliteal 
      Vessel Disease.
PG  - 765-772
LID - 10.6515/ACS.202309_39(5).20230115A [doi]
AB  - BACKGROUND: Patients with chronic limb-threatening ischemia (CLTI) often exhibit 
      long, diffuse, totally occluded and heavily calcified infrapopliteal (IP) 
      lesions. This study evaluated limb salvage after peripheral excimer laser 
      atherectomy (PELA) plus low-pressure balloon inflation (LPBI) without stent 
      deployment in CLTI patients with severe IP disease. METHODS: We retrospectively 
      evaluated 70 consecutive patients with 109 IP vessels who underwent PELA plus 
      LPBI from 2010 to 2013. Technical success was defined as at least one IP 
      straight-line flow being achieved below the malleolus. Binary logistic regression 
      was performed to identify factors associated with 6-month limb salvage. RESULTS: 
      Of the 109 IP vessels, 100 (91.7%) were totally occluded, and none of the 
      patients received a stent. Of the 70 patients, 20% were octogenarians, and 85.8% 
      had a Rutherford-Becker class 5 and 6. The technical success rate was 87.1% and 
      6-month limb salvage rate was 78.6%. Rutherford score was negatively correlated 
      with clinical success (adjusted odds ratio 0.24; p = 0.028). No immediate major 
      cardiovascular events were recorded during admission. CONCLUSIONS: PELA plus LPBI 
      may be a treatment option for complex IP lesions in patients with CLTI. Higher 
      Rutherford class was correlated with a lower 6-month limb salvage rate. However, 
      a large-scale study with a control group is needed to clarify our results.
FAU - Yang, Yuan-Po
AU  - Yang YP
AD  - Department of Cardiology, Changhua Christian Hospital.
AD  - PhD Program in Tissue Engineering and Regenerative Medicine, National Chung-Hsing 
      University and National Health Research Institutes, Taichung.
AD  - Institute of Biomedical Engineering and Nanomedicine, National Health Research 
      Institutes, Zhunan, Miaoli, Taiwan.
FAU - Lin, Tsung-Hsien
AU  - Lin TH
AD  - Division of Cardiology, Kaohsiung Medical University Hospital.
AD  - Faculty of Medicine, Kaohsiung Medical University, Kaohsiung.
FAU - Chou, Chen-Ying
AU  - Chou CY
AD  - Department of Cardiology, Changhua Christian Hospital.
FAU - Lee, Cheng-Liang
AU  - Lee CL
AD  - Department of Cardiology, Changhua Christian Hospital.
FAU - Huang, Hung-Kai
AU  - Huang HK
AD  - Department of Cardiology, Changhua Christian Hospital.
FAU - Wu, Xian-Nin
AU  - Wu XN
AD  - Department of Cardiology, Changhua Christian Hospital.
FAU - Chen, Ching-Pei
AU  - Chen CP
AD  - Department of Cardiology, Changhua Christian Hospital.
AD  - Department of Post-Baccalaureate College Medicine, National Chung-Hsing 
      University, Taichung.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Acta Cardiol Sin
JT  - Acta Cardiologica Sinica
JID - 101687085
PMC - PMC10499955
OTO - NOTNLM
OT  - Chronic total occlusion
OT  - Infrapopliteal artery
OT  - Laser
COIS- All the authors declare no conflict of interest.
EDAT- 2023/09/18 06:42
MHDA- 2023/09/18 06:43
PMCR- 2023/09/01
CRDT- 2023/09/18 04:40
PHST- 2021/10/27 00:00 [received]
PHST- 2023/01/15 00:00 [accepted]
PHST- 2023/09/18 06:43 [medline]
PHST- 2023/09/18 06:42 [pubmed]
PHST- 2023/09/18 04:40 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - 10.6515/ACS.202309_39(5).20230115A [doi]
PST - ppublish
SO  - Acta Cardiol Sin. 2023 Sep;39(5):765-772. doi: 
      10.6515/ACS.202309_39(5).20230115A.