PMID- 37720514
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 10
DP  - 2023
TI  - Monocyte chemoattractant protein-1 as a potential marker for patients with 
      sepsis: a systematic review and meta-analysis.
PG  - 1217784
LID - 10.3389/fmed.2023.1217784 [doi]
LID - 1217784
AB  - OBJECTIVE: To investigate the diagnostic value of monocyte chemoattractant 
      protein-1 (MCP-1) as a biomarker for adult patients with sepsis. METHODS: Related 
      studies on the diagnostic value of MCP-1 in adult patients with sepsis were 
      searched in PubMed, Cochrane Library, Embase, CNKI, CBM, Web of Science, Scopus, 
      and Wanfang Data databases (published to February 20, 2023) was performed if 
      studies assessed the diagnostic accuracy of MCP-1 in adult patients with sepsis 
      and provided appropriate information sufficient to construct a 2 x 2 linked 
      table, studies were included. RESULTS: Data from 8 studies with a total of 805 
      patients were included. The combined sensitivity was 0.84 (95% CI 0.70-0.92), the 
      specificity was 0.82 (95% CI 0.67-0.91), the combined positive likelihood ratio 
      was 3.711 (2.119-6.500), the negative likelihood ratio was 0.287 (0.198-0.415), 
      and the area under the working characteristic curve for combined subjects was 
      0.88. The diagnostic odds ratio (DOR) was 16.508 (7.632-35.706). Meta-regression 
      analysis showed that the results were not significant. Deeks' funnel plot showed 
      that there was no publication bias. CONCLUSION: According to our meta-analysis, 
      MCP-1 is a valuable biomarker and may provide evidence for the diagnosis of 
      sepsis in adults.
CI  - Copyright (c) 2023 Chen, Li and Yu.
FAU - Chen, Zhuo
AU  - Chen Z
AD  - Department of Intensive Care Unit, The Second Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Li, Chenwei
AU  - Li C
AD  - Department of Pulmonary and Critical Care Medicine, The Second Hospital of Dalian 
      Medical University, Dalian, China.
FAU - Yu, Jian
AU  - Yu J
AD  - Department of Intensive Care Unit, The Second Hospital of Dalian Medical 
      University, Dalian, China.
LA  - eng
PT  - Systematic Review
DEP - 20230901
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC10502711
OTO - NOTNLM
OT  - MCP-1
OT  - biomarker
OT  - diagnosis
OT  - meta-analysis
OT  - sepsis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/09/18 06:42
MHDA- 2023/09/18 06:43
PMCR- 2023/09/01
CRDT- 2023/09/18 04:42
PHST- 2023/05/05 00:00 [received]
PHST- 2023/08/17 00:00 [accepted]
PHST- 2023/09/18 06:43 [medline]
PHST- 2023/09/18 06:42 [pubmed]
PHST- 2023/09/18 04:42 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - 10.3389/fmed.2023.1217784 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2023 Sep 1;10:1217784. doi: 10.3389/fmed.2023.1217784. 
      eCollection 2023.