PMID- 37720555
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230920
IS  - 2666-9145 (Electronic)
IS  - 2666-9145 (Linking)
VI  - 3
IP  - 3
DP  - 2023 Sep
TI  - A Datasheet for the INSIGHT University Hospitals Birmingham Retinal Vein 
      Occlusion Data Set.
PG  - 100388
LID - 10.1016/j.xops.2023.100388 [doi]
LID - 100388
AB  - PURPOSE: Retinal vein occlusion (RVO) is the second leading cause of visual loss 
      due to retinal disease. Retinal vein occlusion increases the risk of 
      cardiovascular mortality and the risk of stroke. This article describes the data 
      contained within the INSIGHT eye health data set for RVO and cardiovascular 
      disease. DESIGN: Data set descriptor for routinely collected eye and systemic 
      disease data. PARTICIPANTS: All people who had suffered an RVO aged >/= 18 years 
      old, attending the Ophthalmology Clinic at Queen Elizabeth Hospital, University 
      Hospitals Birmingham (UHB) National Health Service (NHS) Trust were included. 
      METHODS: The INSIGHT Health Data Research Hub for Eye Health is an NHS-led 
      ophthalmic bioresource. It provides researchers with safe access to anonymized 
      routinely collected data from contributing NHS hospitals to advance research for 
      patient benefit. This report describes the INSIGHT UHB RVO and major adverse 
      cardiovascular events data set, a data set of ophthalmology and systemic data 
      derived from the United Kingdom's largest acute care trust. MAIN OUTCOME 
      MEASURES: This data set consists of routinely collected data from the hospital's 
      electronic patient records. The data set primarily includes structured data 
      (relating to their hospital eye care and any cardiovascular data held for the 
      individual) and OCT ocular images. Further details regarding the available data 
      points are available in the supplementary information. RESULTS: At the time point 
      of this analysis (September 30, 2022) the data set was composed of clinical data 
      from 1521 patients, from Medisoft records inception. The data set includes 2196 
      occurrences of RVO affecting 2026 eyes, longitudinal eye follow-up clinical 
      parameters, over 6217 eye-related procedures, and 982 encountered complications. 
      The data set contains information on 2534 major adverse cardiovascular event 
      occurrences, their subtype, number experienced per patient, and chronological 
      relation to RVO event. Longitudinal follow-up data including laboratory results, 
      regular medications, and all-cause mortality are also available within the data 
      set. CONCLUSIONS: This data set descriptor article summarizes the data set 
      contents, the process of its curation, and potential uses. The data set is 
      available through the structured application process that ensures research 
      studies are for patient benefit. Further information regarding the data 
      repository and contact details can be found at https://www.insight.hdrhub.org/. 
      FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found after 
      the references.
CI  - (c) 2023 by the American Academy of Ophthalmology.
FAU - Bilton, Edward J
AU  - Bilton EJ
AD  - INSIGHT, Health Data Research Hub for Eye Health, University Hospitals Birmingham 
      NHS Foundation Trust, Birmingham, United Kingdom.
FAU - Guggenheim, Emily J
AU  - Guggenheim EJ
AD  - INSIGHT, Health Data Research Hub for Eye Health, University Hospitals Birmingham 
      NHS Foundation Trust, Birmingham, United Kingdom.
FAU - Baranyi, Balazs
AU  - Baranyi B
AD  - INSIGHT, Health Data Research Hub for Eye Health, University Hospitals Birmingham 
      NHS Foundation Trust, Birmingham, United Kingdom.
FAU - Radovanovic, Charlotte
AU  - Radovanovic C
AD  - INSIGHT, Health Data Research Hub for Eye Health, University Hospitals Birmingham 
      NHS Foundation Trust, Birmingham, United Kingdom.
FAU - Williams, Rowena L
AU  - Williams RL
AD  - INSIGHT, Health Data Research Hub for Eye Health, University Hospitals Birmingham 
      NHS Foundation Trust, Birmingham, United Kingdom.
FAU - Bradlow, William
AU  - Bradlow W
AD  - Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, 
      University of Birmingham, United Kingdom.
AD  - University Hospitals Birmingham, NHS Foundation Trust, United Kingdom.
AD  - MRC Health Data Research UK (HDR UK) Midlands, United Kingdom.
FAU - Denniston, Alastair K
AU  - Denniston AK
AD  - INSIGHT, Health Data Research Hub for Eye Health, University Hospitals Birmingham 
      NHS Foundation Trust, Birmingham, United Kingdom.
AD  - Academic Unit of Ophthalmology, Institute of Inflammation & Ageing, College of 
      Medical and Dental Sciences, University of Birmingham, United Kingdom.
AD  - Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, 
      Birmingham, United Kingdom.
FAU - Mollan, Susan P
AU  - Mollan SP
AD  - INSIGHT, Health Data Research Hub for Eye Health, University Hospitals Birmingham 
      NHS Foundation Trust, Birmingham, United Kingdom.
AD  - Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, 
      Birmingham, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20230822
PL  - Netherlands
TA  - Ophthalmol Sci
JT  - Ophthalmology science
JID - 9918230896206676
PMC - PMC10500462
OTO - NOTNLM
OT  - Biomedical data
OT  - Data set
OT  - Major Cardiovascular events
OT  - Myocardial infarction
OT  - Retinal vein occlusion
EDAT- 2023/09/18 06:41
MHDA- 2023/09/18 06:42
PMCR- 2023/08/22
CRDT- 2023/09/18 04:42
PHST- 2023/01/17 00:00 [received]
PHST- 2023/08/16 00:00 [revised]
PHST- 2023/08/17 00:00 [accepted]
PHST- 2023/09/18 06:42 [medline]
PHST- 2023/09/18 06:41 [pubmed]
PHST- 2023/09/18 04:42 [entrez]
PHST- 2023/08/22 00:00 [pmc-release]
AID - S2666-9145(23)00120-3 [pii]
AID - 100388 [pii]
AID - 10.1016/j.xops.2023.100388 [doi]
PST - epublish
SO  - Ophthalmol Sci. 2023 Aug 22;3(3):100388. doi: 10.1016/j.xops.2023.100388. 
      eCollection 2023 Sep.