PMID- 37722616
OWN - NLM
STAT- MEDLINE
DCOM- 20231009
LR  - 20231009
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 180
DP  - 2023 Oct
TI  - Evaluation of possible attenuative role of chrysoeriol against polyethylene 
      microplastics instigated testicular damage: A biochemical, spermatogenic and 
      histological study.
PG  - 114043
LID - S0278-6915(23)00445-3 [pii]
LID - 10.1016/j.fct.2023.114043 [doi]
AB  - The current study was designed to evaluate the protective role of chrysoeriol 
      against polyethylene microplastics (PE-MP) induced testicular damage. Forty eight 
      male rats were distributed into 4 equal groups: vehicle control, PE-MP 
      administrated, PE-MP + chrysoeriol co-administrated and only chrysoeriol 
      supplemented group. The administration of PE-MP significantly reduced the 
      activities of anti-oxidant enzymes, i.e., glutathione peroxidase, catalase, 
      glutathione reductase and superoxide dismutase, whereas the levels of reactive 
      oxygen species and malondialdehyde were increased. PE-MP exposure increased the 
      levels of inflammatory markers (TNF-alpha, 1L-1beta, NF-kappabeta, IL-6 & COX-2). Additionally, 
      a considerable increase was observed in dead sperms number, abnormality of sperms 
      (tail, midpiece and head), while a potential decrease was noticed in sperm 
      motility in PE-MP treated rats. The expressions of steroidogenic enzymes were 
      also decreased in PE-MP administrated group. The levels of plasma testosterone, 
      luteinizing & follicle stimulating hormone were decreased in PE-MP treated group. 
      Moreover, Bax and Caspase-3 expressions were increased, whereas Bcl-2 expressions 
      were reduced. Furthermore, histopathological analysis showed that PE-MP exposure 
      considerably damaged the testicular tissues. However, chrysoeriol supplementation 
      potentially decreased all the adverse effects induced by PE-MP. Taken together, 
      our findings indicate that chrysoeriol holds significant potential to avert 
      PE-MP-induced testicular damage due to its androgenic, anti-apoptotic, 
      anti-oxidant and anti-inflammatory nature.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Ijaz, Muhammad Umar
AU  - Ijaz MU
AD  - Department of Zoology, Wildlife and Fisheries, University of Agriculture, 
      Faisalabad 38040, Pakistan. Electronic address: umar.ijaz@uaf.edu.pk.
FAU - Saher, Faria
AU  - Saher F
AD  - Department of Zoology, Wildlife and Fisheries, University of Agriculture, 
      Faisalabad 38040, Pakistan.
FAU - Aslam, Nemra
AU  - Aslam N
AD  - Faisalabad Medical University, Faisalabad 38000, Pakistan.
FAU - Hamza, Ali
AU  - Hamza A
AD  - Department of Zoology, Wildlife and Fisheries, University of Agriculture, 
      Faisalabad 38040, Pakistan.
FAU - Anwar, Haseeb
AU  - Anwar H
AD  - Department of Physiology, Government College University, Faisalabad 38000, 
      Pakistan.
FAU - Alkahtani, Saad
AU  - Alkahtani S
AD  - Department of Zoology, College of Science, King Saud University, P.O. Box 2455, 
      Riyadh, 11451, Saudi Arabia.
FAU - Khan, Hammad Ahmad
AU  - Khan HA
AD  - Department of Zoology, Wildlife and Fisheries, University of Agriculture, 
      Faisalabad 38040, Pakistan.
FAU - Riaz, Mian Nadeem
AU  - Riaz MN
AD  - Texas A & M University, College Station, TX, 2476, USA.
LA  - eng
PT  - Journal Article
DEP - 20230916
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Antioxidants)
RN  - Q813145M20 (chrysoeriol)
RN  - 0 (Microplastics)
RN  - 0 (Plastics)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Male
MH  - Rats
MH  - Animals
MH  - *Antioxidants/pharmacology/metabolism
MH  - *Microplastics/metabolism
MH  - Plastics
MH  - Polyethylene/toxicity
MH  - Oxidative Stress
MH  - Sperm Motility
MH  - Testis
OTO - NOTNLM
OT  - Chrysoeriol
OT  - Inflammation
OT  - Oxidative stress
OT  - Polyethylene microplastic
OT  - Steroidogenesis
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/09/19 00:43
MHDA- 2023/10/09 06:42
CRDT- 2023/09/18 19:17
PHST- 2023/06/02 00:00 [received]
PHST- 2023/09/10 00:00 [revised]
PHST- 2023/09/14 00:00 [accepted]
PHST- 2023/10/09 06:42 [medline]
PHST- 2023/09/19 00:43 [pubmed]
PHST- 2023/09/18 19:17 [entrez]
AID - S0278-6915(23)00445-3 [pii]
AID - 10.1016/j.fct.2023.114043 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2023 Oct;180:114043. doi: 10.1016/j.fct.2023.114043. Epub 2023 
      Sep 16.