PMID- 37724352
OWN - NLM
STAT- MEDLINE
DCOM- 20231002
LR  - 20231015
IS  - 1747-0927 (Electronic)
IS  - 1747-0919 (Linking)
VI  - 18
IP  - 4
DP  - 2023 Aug
TI  - The neurobiological map of theory of mind and pragmatic communication in autism.
PG  - 191-204
LID - 10.1080/17470919.2023.2242095 [doi]
AB  - Children with autism often have difficulty with Theory of Mind (ToM), the ability 
      to infer mental states, and pragmatic skills, the contextual use of language. 
      Neuroimaging research suggests ToM and pragmatic skills overlap, as the ability 
      to understand another's mental state is a prerequisite to interpersonal 
      communication. To our knowledge, no study in the last decade has examined this 
      overlap further. To assess the emerging consensus across neuroimaging studies of 
      ToM and pragmatic skills in autism, we used coordinate-based activation 
      likelihood estimation (ALE) analysis of 35 functional magnetic resonance imaging 
      (MRI) studies (13 pragmatic skills, 22 ToM), resulting in a meta-analysis of 
      1,295 participants (647 autistic, 648 non-autistic) aged 7 to 49 years. Group 
      difference analysis revealed decreased left inferior frontal gyrus (LIFG) 
      activation in autistic participants during pragmatic skills tasks. For ToM tasks, 
      we found reduced anterior cingulate cortex (ACC), medial prefrontal cortex 
      (MPFC), and temporoparietal junction (TPJ) activation in autistic participants. 
      Collectively, both ToM and pragmatic tasks showed activation in IFG and superior 
      temporal gyrus (STG) and a reduction in left hemispheric activation in autistic 
      participants. Overall, the findings underscore the cognitive and neural 
      processing similarities between ToM and pragmatic skills, and their underlying 
      neurobiological differences in autism.
FAU - Duvall, Lauren
AU  - Duvall L
AD  - Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, 
      MD, USA.
FAU - May, Kaitlyn E
AU  - May KE
AUID- ORCID: 0000-0001-6364-4952
AD  - Department of Educational Studies in Psychology, Research Methodologies, and 
      Counseling, University of Alabama, Tuscaloosa, AL,USA.
FAU - Waltz, Abby
AU  - Waltz A
AD  - Department of Psychology & the Center for Innovative Research in Autism, 
      University of Alabama, Tuscaloosa, AL, USA.
FAU - Kana, Rajesh K
AU  - Kana RK
AD  - Department of Psychology & the Center for Innovative Research in Autism, 
      University of Alabama, Tuscaloosa, AL, USA.
LA  - eng
GR  - R01 DC016303/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
DEP - 20230930
PL  - England
TA  - Soc Neurosci
JT  - Social neuroscience
JID - 101279009
SB  - IM
MH  - Child
MH  - Humans
MH  - *Autistic Disorder/diagnostic imaging
MH  - *Theory of Mind/physiology
MH  - Prefrontal Cortex/physiology
MH  - Magnetic Resonance Imaging/methods
MH  - Language
MH  - *Autism Spectrum Disorder/diagnostic imaging/psychology
OTO - NOTNLM
OT  - Autism spectrum disorder
OT  - neuroimaging
OT  - pragmatic language
OT  - theory of mind
EDAT- 2023/09/19 06:43
MHDA- 2023/10/02 06:42
CRDT- 2023/09/19 04:03
PHST- 2023/10/02 06:42 [medline]
PHST- 2023/09/19 06:43 [pubmed]
PHST- 2023/09/19 04:03 [entrez]
AID - 10.1080/17470919.2023.2242095 [doi]
PST - ppublish
SO  - Soc Neurosci. 2023 Aug;18(4):191-204. doi: 10.1080/17470919.2023.2242095. Epub 
      2023 Sep 30.