PMID- 37724419
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240201
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Print)
IS  - 1582-1838 (Linking)
VI  - 27
IP  - 23
DP  - 2023 Dec
TI  - An effective disease diagnostic model related to pyroptosis in ischemic 
      cardiomyopathy.
PG  - 3816-3826
LID - 10.1111/jcmm.17957 [doi]
AB  - Pyroptosis is involved in ischemic cardiomyopathy (ICM). The study aimed to 
      investigate the pyroptosis-related genes and clarify their diagnostic value in 
      ICM. The bioinformatics method identified the differential pyroptosis genes 
      between the normal control and ICM samples from online datasets. Then, 
      protein-protein interaction (PPI) and function analysis were carried out to 
      explore the function of these genes. Following, subtype analysis was performed 
      using ConsensusClusterPlus, functions, immune score, stromal score, immune cell 
      proportion and human leukocyte antigen (HLA) genes between subtypes were 
      investigated. Moreover, optimal pyroptosis genes were selected using the least 
      absolute shrinkage and selection operator (LASSO) analysis to construct a 
      diagnostic model and evaluate its effectiveness using receiver operator 
      characteristic (ROC) analysis. Twenty-one differential expressed pyroptosis genes 
      were identified, and these genes were related to immune and pyroptosis. Subtype 
      analysis identified two obvious subtypes: sub-1 and sub-2. And LASSO identified 
      13 optimal genes used to construct the diagnostic model. The diagnostic model in 
      ICM diagnosis with the area under ROC (AUC) was 0.965. Our results suggested that 
      pyroptosis was tightly associated with ICM.
CI  - (c) 2023 The Authors. Journal of Cellular and Molecular Medicine published by 
      Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
FAU - Jin, Zhankui
AU  - Jin Z
AD  - Department of Orthopedics, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Liu, Fuqiang
AU  - Liu F
AUID- ORCID: 0000-0003-0371-639X
AD  - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhang, Guoan
AU  - Zhang G
AD  - Department of Cardiovascular Surgery, Shaanxi Provincial People's Hospital, 
      Xi'an, China.
FAU - Zhang, Jingtao
AU  - Zhang J
AD  - Department of Cardiovascular Surgery, Shaanxi Provincial People's Hospital, 
      Xi'an, China.
FAU - Zhao, Xiangrong
AU  - Zhao X
AD  - Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi 
      Provincial People's Hospital, Xi'an, China.
AD  - Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial 
      People's Hospital, Xi'an, China.
FAU - Huo, Xueping
AU  - Huo X
AD  - Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi 
      Provincial People's Hospital, Xi'an, China.
AD  - Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial 
      People's Hospital, Xi'an, China.
FAU - Huang, Xiaoyan
AU  - Huang X
AUID- ORCID: 0000-0002-1606-168X
AD  - Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi 
      Provincial People's Hospital, Xi'an, China.
AD  - Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial 
      People's Hospital, Xi'an, China.
FAU - Xu, Cuixiang
AU  - Xu C
AD  - Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi 
      Provincial People's Hospital, Xi'an, China.
AD  - Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial 
      People's Hospital, Xi'an, China.
LA  - eng
GR  - 2022XXG-QN-001/Open Project of the Key Laboratory for the Prevention and 
      Treatment of Cardiovascular Diseases in Shaanxi Province with Integrated 
      Traditional Chinese and Western Medicine in Shaanxi University of Traditional 
      Chinese Medicine/
GR  - 2022YJY-59/Science and Technology Incubation Fund Program of Shaanxi Provincial 
      People's Hospital/
GR  - 22JS035/the Key Projects of Shaanxi Provincial Department of Education/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230919
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
SB  - IM
MH  - Humans
MH  - Pyroptosis/genetics
MH  - *Myocardial Ischemia/diagnosis/genetics
MH  - Computational Biology
MH  - *Cardiomyopathies/diagnosis/genetics
PMC - PMC10718138
OTO - NOTNLM
OT  - diagnosis
OT  - immune
OT  - ischemic cardiomyopathy
OT  - microenvironment
OT  - pyroptosis
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/19 06:43
MHDA- 2023/12/17 09:45
PMCR- 2023/09/19
CRDT- 2023/09/19 04:23
PHST- 2023/08/10 00:00 [revised]
PHST- 2023/06/06 00:00 [received]
PHST- 2023/09/04 00:00 [accepted]
PHST- 2023/12/17 09:45 [medline]
PHST- 2023/09/19 06:43 [pubmed]
PHST- 2023/09/19 04:23 [entrez]
PHST- 2023/09/19 00:00 [pmc-release]
AID - JCMM17957 [pii]
AID - 10.1111/jcmm.17957 [doi]
PST - ppublish
SO  - J Cell Mol Med. 2023 Dec;27(23):3816-3826. doi: 10.1111/jcmm.17957. Epub 2023 Sep 
      19.