PMID- 37724446
OWN - NLM
STAT- MEDLINE
DCOM- 20231011
LR  - 20231011
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 14
IP  - 19
DP  - 2023 Oct 2
TI  - The relationship between vitamin K and T2DM: a systematic review and 
      meta-analysis.
PG  - 8951-8963
LID - 10.1039/d3fo02943c [doi]
AB  - Background: Previous studies have shown the potential role of vitamin K 
      supplementation in the prevention and treatment of many diseases. However, the 
      effect of vitamin K supplementation on blood glucose remains controversial. The 
      purpose of this study was to assess the effects of vitamin K supplementation on 
      glycemia-related indicators, including Fasting Blood Sugar (FBS), Fasting Insulin 
      (FINS) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). The 
      potential association between vitamin K and type 2 diabetes mellitus (T2DM) risk 
      was also evaluated. Methods: Up to April 2023, Cochrane, PubMed, Web of Science, 
      Medline and EMBASE databases were searched to assess the effects of vitamin K on 
      blood glucose and the risk of developing T2DM. Results: A meta-analysis of seven 
      studies (813 participants) found vitamin K supplementation significantly reduced 
      FBS (SMD = -0.150 mg dl(-1), 95% CI = -0.290, -0.010 mg dl(-1)) and HOMA-IR (SMD 
      = -0.200, 95% CI = -0.330, -0.060), but not FINS. Five studies with a total of 
      105 798 participants were included in the meta-analysis of the association 
      between vitamin K and T2DM. The results showed that vitamin K was associated with 
      the reduced risk of developing T2DM (HR = 0.79, 95% CI [0.71-0.88], P < 0.001). 
      Conclusion: The meta-analysis demonstrated that vitamin K supplementation had a 
      significant effect on the regulation of FBS and HOMA-IR in the population. 
      Moreover, vitamin K was associated with the reduced risk of developing T2DM. 
      Considering some limitations found in this study, additional data from large 
      clinical trials are needed.
FAU - Qu, Boyang
AU  - Qu B
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Jilin 
      University, Changchun, China. cuiweiwei@jlu.edu.cn.
FAU - Yan, Shoumeng
AU  - Yan S
AD  - School of Nursing, Jilin University, Changchun, China.
FAU - Ao, Yanrong
AU  - Ao Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Jilin 
      University, Changchun, China. cuiweiwei@jlu.edu.cn.
FAU - Chen, Xingyang
AU  - Chen X
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Jilin 
      University, Changchun, China. cuiweiwei@jlu.edu.cn.
FAU - Zheng, Xiangyu
AU  - Zheng X
AD  - Department of Neurology and Neuroscience Center, The First Hospital of Jilin 
      University, Changchun, China. xiangyuzheng@jlu.edu.cn.
FAU - Cui, Weiwei
AU  - Cui W
AUID- ORCID: 0000-0002-0028-8564
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Jilin 
      University, Changchun, China. cuiweiwei@jlu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20231002
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 12001-79-5 (Vitamin K)
SB  - IM
MH  - Humans
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Dietary Supplements
MH  - Insulin
MH  - *Insulin Resistance/physiology
MH  - *Vitamin K
EDAT- 2023/09/19 06:42
MHDA- 2023/10/03 06:47
CRDT- 2023/09/19 04:43
PHST- 2023/10/03 06:47 [medline]
PHST- 2023/09/19 06:42 [pubmed]
PHST- 2023/09/19 04:43 [entrez]
AID - 10.1039/d3fo02943c [doi]
PST - epublish
SO  - Food Funct. 2023 Oct 2;14(19):8951-8963. doi: 10.1039/d3fo02943c.