PMID- 37724847
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231103
IS  - 1945-7243 (Electronic)
IS  - 0046-9580 (Print)
IS  - 0046-9580 (Linking)
VI  - 60
DP  - 2023 Jan-Dec
TI  - Frailty Index was Associated With Adverse Outcomes in Admitted Elderly Patients 
      With Type 2 Diabetes Mellitus.
PG  - 469580231201022
LID - 10.1177/00469580231201022 [doi]
LID - 00469580231201022
AB  - We aimed to investigate the role of the laboratory frailty index (LFI) in 
      diabetic complications and incident disability in admitted older patients with 
      type 2 diabetes mellitus (T2DM). We retrospectively collected the clinical data 
      of older patients with T2DM from December 2018 to May 2020. Frailty was 
      quantified using the LFI, which considers the accumulation of 27 items of 
      abnormal laboratory outcomes. Univariate and multivariate analyses were performed 
      to evaluate the relationship between LFI and diabetes-related adverse outcomes. 
      In total, 293 consecutive older patients with T2DM were recruited for this study. 
      According to the predefined LFI criteria, 110 (37.5%) participants were 
      non-frail, 131 (44.7%) were prefrail, and 52 (17.8%) were frail. Univariate and 
      multivariate analysis revealed that LFI was associated with the diabetic 
      microangiopathy complications (odds ratio for prefrail [OR(prefrail)] 1.760, 95% 
      confidence interval for prefrail [CI(prefrail)] 1.019-3.041, P = .043; OR(frail) 
      4.667, 95% CI(frail) 2.012-10.826, P < .001) and activities of daily living (ADL) 
      disability (OR(prefrail) 2.323, 95% CI(prefrail) 1.209-4.463, P = .011; OR(frail) 
      9.367, 95% CI(frail) 4.030-21.775, P < .001), but not with the diabetic 
      macroangiopathy complications and diabetic peripheral neuropathy. Frailty, as 
      determined by the LFI, was proven to be an effective tool for the prediction of 
      diabetic microangiopathy complications and ADL disability.
FAU - Lin, Yi
AU  - Lin Y
AD  - Department of Endocrinology, The Third Affiliated Hospital of Shanghai 
      University, Wenzhou People's Hospital, Zhejiang, China.
FAU - Shi, Xiaochong
AU  - Shi X
AD  - Department of Endocrinology, The Third Affiliated Hospital of Shanghai 
      University, Wenzhou People's Hospital, Zhejiang, China.
FAU - Huang, Lingling
AU  - Huang L
AD  - Department of Endocrinology, The Third Affiliated Hospital of Shanghai 
      University, Wenzhou People's Hospital, Zhejiang, China.
FAU - Chen, Aixia
AU  - Chen A
AD  - Department of Endocrinology, The Third Affiliated Hospital of Shanghai 
      University, Wenzhou People's Hospital, Zhejiang, China.
FAU - Zhu, Haihui
AU  - Zhu H
AUID- ORCID: 0000-0002-4396-5481
AD  - Department of Endocrinology, The Third Affiliated Hospital of Shanghai 
      University, Wenzhou People's Hospital, Zhejiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inquiry
JT  - Inquiry : a journal of medical care organization, provision and financing
JID - 0171671
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Diabetes Mellitus, Type 2
MH  - *Frailty/epidemiology
MH  - Activities of Daily Living
MH  - Retrospective Studies
MH  - *Diabetic Angiopathies
MH  - Geriatric Assessment
PMC - PMC10510342
OTO - NOTNLM
OT  - inflammation
OT  - laboratory frailty index
OT  - macroangiopathy complications
OT  - microangiopathy complications
OT  - type 2 diabetes mellitus
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/09/19 17:43
MHDA- 2023/09/19 17:44
PMCR- 2023/09/19
CRDT- 2023/09/19 08:42
PHST- 2023/09/19 17:44 [medline]
PHST- 2023/09/19 17:43 [pubmed]
PHST- 2023/09/19 08:42 [entrez]
PHST- 2023/09/19 00:00 [pmc-release]
AID - 10.1177_00469580231201022 [pii]
AID - 10.1177/00469580231201022 [doi]
PST - ppublish
SO  - Inquiry. 2023 Jan-Dec;60:469580231201022. doi: 10.1177/00469580231201022.