PMID- 37726297
OWN - NLM
STAT- MEDLINE
DCOM- 20230921
LR  - 20231121
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Sep 19
TI  - Blue 405 nm LED light effectively inactivates bacterial pathogens on substrates 
      and packaging materials used in food processing.
PG  - 15472
LID - 10.1038/s41598-023-42347-z [doi]
LID - 15472
AB  - This study investigates the antimicrobial effectiveness of 405 nm light emitting 
      diodes (LEDs) against pathogenic Escherichia coli O157:H7, Listeria 
      monocytogenes, Pseudomonas aeruginosa, Salmonella Typhimurium, and Staphylococcus 
      aureus, in thin liquid films (TLF) and on solid surfaces. Stainless steel (SS), 
      high density polyethylene (HDPE), low density polyethylene (LDPE), and 
      borosilicate glass were used as materials typically encountered in food 
      processing, food service, and clinical environments. Anodic aluminum oxide (AAO) 
      coupons with nanoscale topography were used, to evaluate the effect of topography 
      on inactivation. The impact of surface roughness, hydrophobicity, and 
      reflectivity on inactivation was assessed. A 48 h exposure to 405 nm led to 
      reductions ranging from 1.3 (E. coli) to 5.7 (S. aureus) log CFU in TLF and 3.1 
      to 6.3 log CFU on different solid contact surfaces and packaging materials. All 
      inactivation curves were nonlinear and followed Weibull kinetics, with better 
      inactivation predictions on surfaces (0.89 </= R(2) </= 1.0) compared to TLF 
      (0.76 </= R(2) </= 0.99). The fastest inactivation rate was observed on small 
      nanopore AAO coupons inoculated with L. monocytogenes and S. aureus, indicating 
      inactivation enhancing potential of these surfaces. These results demonstrate 
      significant promise of 405 nm LEDs for antimicrobial applications in food 
      processing and handling and the healthcare industry.
CI  - (c) 2023. Springer Nature Limited.
FAU - Chen, Hanyu
AU  - Chen H
AD  - Department of Food Science, Cornell University, Ithaca, NY, 14853, USA.
FAU - Cheng, Yifan
AU  - Cheng Y
AD  - Department of Food Science, Virginia Polytechnic Institute and State University, 
      Blacksburg, VA, 24061, USA.
FAU - Moraru, Carmen I
AU  - Moraru CI
AUID- ORCID: 0000-0001-8307-7123
AD  - Department of Food Science, Cornell University, Ithaca, NY, 14853, USA. 
      cim24@cornell.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20230919
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - LMI26O6933 (Aluminum Oxide)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - *Staphylococcus aureus
MH  - Food Handling
MH  - Motion Pictures
MH  - Aluminum Oxide
MH  - *Escherichia coli O157
MH  - Polyethylene
PMC - PMC10509141
COIS- The authors declare no competing interests.
EDAT- 2023/09/20 00:43
MHDA- 2023/09/21 06:42
PMCR- 2023/09/19
CRDT- 2023/09/19 23:18
PHST- 2022/12/16 00:00 [received]
PHST- 2023/09/08 00:00 [accepted]
PHST- 2023/09/21 06:42 [medline]
PHST- 2023/09/20 00:43 [pubmed]
PHST- 2023/09/19 23:18 [entrez]
PHST- 2023/09/19 00:00 [pmc-release]
AID - 10.1038/s41598-023-42347-z [pii]
AID - 42347 [pii]
AID - 10.1038/s41598-023-42347-z [doi]
PST - epublish
SO  - Sci Rep. 2023 Sep 19;13(1):15472. doi: 10.1038/s41598-023-42347-z.