PMID- 37726436
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231112
IS  - 1881-1469 (Electronic)
IS  - 0021-8820 (Linking)
VI  - 76
IP  - 11
DP  - 2023 Nov
TI  - Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by 
      marine-derived Streptomyces sp. KM77-8.
PG  - 650-657
LID - 10.1038/s41429-023-00648-5 [doi]
AB  - A new antibiotic named haneummycin (1) was isolated from a culture broth of 
      marine-derived Streptomyces sp. KM77-8 by solvent extraction and HPLC using a C4 
      column. The structure of 1 was elucidated including relative stereochemistry as a 
      new 22-membered macrolide lactam associated with a cyclopentanone and three 
      sugars by various spectroscopic analyses, such as MS and NMR. Compound 1 
      displayed significant antibacterial activities against Gram-positive bacteria 
      including vancomycin-resistant Enterococcus faecium (VRE) and 
      methicillin-resistant Staphylococcus aureus (MRSA) with both MIC values of 
      8.0 microg ml(-1).
CI  - (c) 2023. The Author(s), under exclusive licence to the Japan Antibiotics Research 
      Association.
FAU - Uemura, Moeka
AU  - Uemura M
AD  - Graduate School of Marine Science and Technology, Tokyo University of Marine 
      Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo, 108-8477, Japan.
FAU - Kobayashi, Keisuke
AU  - Kobayashi K
AUID- ORCID: 0000-0001-9580-2484
AD  - Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, 
      Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
AD  - Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 
      Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
FAU - Sato, Noriko
AU  - Sato N
AD  - Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 
      Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
FAU - Nagai, Kenichiro
AU  - Nagai K
AD  - Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 
      Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
FAU - Seki, Reiko
AU  - Seki R
AD  - Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 
      Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
FAU - Kamio, Michiya
AU  - Kamio M
AD  - Graduate School of Marine Science and Technology, Tokyo University of Marine 
      Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo, 108-8477, Japan.
FAU - Fukuda, Takashi
AU  - Fukuda T
AD  - Department of Fisheries, Faculty of Agriculture and Agricultural Technology and 
      Innovation Research Institute, Kindai University, 3327-204 Nakamachi, Nara, 
      631-8505, Japan.
FAU - Tsubouchi, Taishi
AU  - Tsubouchi T
AD  - Department of Bacteriology, Osaka Metropolitan University, Graduate School of 
      Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
AD  - Research Center for Infectious Disease Sciences, Osaka Metropolitan University, 
      Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Tomoda, Hiroshi
AU  - Tomoda H
AD  - Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, 
      Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
FAU - Ohshiro, Taichi
AU  - Ohshiro T
AD  - Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, 
      Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
AD  - Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 
      Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
FAU - Kobayashi, Takeshi
AU  - Kobayashi T
AD  - Graduate School of Marine Science and Technology, Tokyo University of Marine 
      Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo, 108-8477, Japan.
FAU - Terahara, Takeshi
AU  - Terahara T
AD  - Graduate School of Marine Science and Technology, Tokyo University of Marine 
      Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo, 108-8477, Japan. 
      terahara@kaiyodai.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230919
PL  - England
TA  - J Antibiot (Tokyo)
JT  - The Journal of antibiotics
JID - 0151115
RN  - 0 (Lactams)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Macrolides)
SB  - IM
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Lactams/pharmacology
MH  - *Streptomyces/chemistry
MH  - Anti-Bacterial Agents/chemistry
MH  - Macrolides/pharmacology
MH  - Microbial Sensitivity Tests
EDAT- 2023/09/20 00:43
MHDA- 2023/10/30 06:47
CRDT- 2023/09/19 23:31
PHST- 2023/04/28 00:00 [received]
PHST- 2023/08/04 00:00 [accepted]
PHST- 2023/07/21 00:00 [revised]
PHST- 2023/10/30 06:47 [medline]
PHST- 2023/09/20 00:43 [pubmed]
PHST- 2023/09/19 23:31 [entrez]
AID - 10.1038/s41429-023-00648-5 [pii]
AID - 10.1038/s41429-023-00648-5 [doi]
PST - ppublish
SO  - J Antibiot (Tokyo). 2023 Nov;76(11):650-657. doi: 10.1038/s41429-023-00648-5. 
      Epub 2023 Sep 19.