PMID- 37726605
OWN - NLM
STAT- MEDLINE
DCOM- 20230921
LR  - 20230921
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 38
IP  - 9
DP  - 2022 Sep
TI  - Myocardial function in COVID-19 patients after hospital discharge: a descriptive 
      study comparing the first and second 'wave' patients.
PG  - 1951-1960
LID - 10.1007/s10554-022-02590-3 [doi]
AB  - In hospitalized COVID-19 patients, myocardial injury and echocardiographic 
      abnormalities have been described. The present study investigates cardiac 
      function in COVID-19 patients 6 weeks post-discharge and evaluates its relation 
      to New York Heart Association (NYHA) class. Furthermore cardiac function 
      post-discharge between the first and second wave COVID-19 patients was compared. 
      We evaluated 146 patients at the outpatient clinic of the Leiden University 
      Medical Centre. NYHA class of II or higher was reported by 53% of patients. 
      Transthoracic echocardiography was used to assess cardiac function. Overall, in 
      27% of patients reduced left ventricular (LV) ejection fraction was observed and 
      in 29% of patients LV global longitudinal strain was impaired (> - 16%). However 
      no differences were observed in these parameters reflecting LV function between 
      the first and second wave patients. Right ventricular (RV) dysfunction as 
      assessed by tricuspid annular systolic planar excursion (< 17 mm) was present in 
      14% of patients, this was also not different between the first and second wave 
      patients (15% vs. 12%; p = 0.63); similar results were found for RV fraction area 
      change and RV strain. Reduced LV and RV function were not associated with NYHA 
      class. In COVID-19 patients at 6 weeks post-discharge, mild abnormalities in 
      cardiac function were found. However these were not related to NYHA class and 
      there was no difference in cardiac function between the first and second wave 
      patients. Long term symptoms post-COVID might therefore not be explained by 
      mildly abnormal cardiac function.
CI  - (c) 2022. The Author(s).
FAU - Elffers, T W
AU  - Elffers TW
AD  - Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 
      2333ZA, Leiden, The Netherlands.
FAU - de Graaf, M A
AU  - de Graaf MA
AUID- ORCID: 0000-0001-8134-0004
AD  - Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 
      2333ZA, Leiden, The Netherlands.
FAU - Regeer, M V
AU  - Regeer MV
AD  - Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 
      2333ZA, Leiden, The Netherlands.
FAU - Omara, S
AU  - Omara S
AD  - Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 
      2333ZA, Leiden, The Netherlands.
FAU - Schalij, M J
AU  - Schalij MJ
AD  - Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 
      2333ZA, Leiden, The Netherlands.
FAU - Groeneveld, G H
AU  - Groeneveld GH
AD  - Department of Infectious Diseases and Internal Medicine, Leiden University 
      Medical Centre, Leiden, The Netherlands.
FAU - Roukens, A H E
AU  - Roukens AHE
AD  - Department of Infectious Diseases and Internal Medicine, Leiden University 
      Medical Centre, Leiden, The Netherlands.
FAU - Geelhoed, J J M
AU  - Geelhoed JJM
AD  - Department of Pulmonology, Leiden University Medical Centre, Leiden, The 
      Netherlands.
FAU - Antoni, M L
AU  - Antoni ML
AD  - Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 
      2333ZA, Leiden, The Netherlands. m.l.antoni@lumc.nl.
LA  - eng
PT  - Journal Article
DEP - 20220416
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Humans
MH  - *COVID-19
MH  - Patient Discharge
MH  - Aftercare
MH  - Predictive Value of Tests
MH  - Post-Acute COVID-19 Syndrome
MH  - *Ventricular Dysfunction, Right/diagnostic imaging/etiology
MH  - Hospitals
PMC - PMC9013213
OTO - NOTNLM
OT  - COVID-19
OT  - Echocardiography
OT  - Out-patient clinic
OT  - Strain
COIS- There is no conflict of interest for the present manuscript.
EDAT- 2023/09/20 00:43
MHDA- 2023/09/21 06:42
PMCR- 2022/04/16
CRDT- 2023/09/19 23:40
PHST- 2021/12/07 00:00 [received]
PHST- 2022/03/03 00:00 [accepted]
PHST- 2023/09/21 06:42 [medline]
PHST- 2023/09/20 00:43 [pubmed]
PHST- 2023/09/19 23:40 [entrez]
PHST- 2022/04/16 00:00 [pmc-release]
AID - 10.1007/s10554-022-02590-3 [pii]
AID - 2590 [pii]
AID - 10.1007/s10554-022-02590-3 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2022 Sep;38(9):1951-1960. doi: 
      10.1007/s10554-022-02590-3. Epub 2022 Apr 16.