PMID- 37727308 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230921 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 10 DP - 2023 TI - Left atrial function index predicts poor outcomes in acute myocardial infarction patients treated with percutaneous coronary intervention. PG - 1043775 LID - 10.3389/fcvm.2023.1043775 [doi] LID - 1043775 AB - BACKGROUND AND AIMS: The left atrial function index (LAFI) is an index that combines the left atrial emptying fraction, adjusted left atrial volume and stroke volume. The prognostic value of LAFI in acute myocardial infarction (AMI) patients treated with percutaneous coronary intervention (PCI) is unknown. This study aims to determine whether LAFI predicts prognosis in AMI patients treated with PCI. METHODS: Patients with newly diagnosed AMI who were treated with PCI at Hunan Provincial People's Hospital from March 2020 to October 2021 were prospectively enrolled. All patients underwent transthoracic echocardiography (TTE) at baseline and follow-up. The endpoint events included rehospitalization due to unstable angina, nonfatal myocardial infarction, rehospitalization due to heart failure and cardiovascular death. RESULTS: A total of 368 patients with AMI (92 women; mean age, 61.45 +/- 11.91 years) were studied with a median follow-up of 14 +/- 6.58 months. Sixty-nine patients had endpoint events. Patients who presented with events had a significantly lower LAFI than patients without events (34.25 +/- 12.86 vs. 48.38 +/- 19.42, P < 0.0001). Multivariate Cox analysis demonstrated that LAFI (HR = 0.97 [95% CI: 0.95; 0.99]; P = 0.012) and the Killip classification (HR = 1.51 [95% CI: 1.03; 2.22]; P = 0.034) were independently predictive of endpoint events. Kaplan-Meier survival curves showed that patients with LAFI 40.17 cm/ml/m(2) (HR = 8.53 [95% CI: 4.74; 15.35]; P < 0.0001). CONCLUSION: LAFI is a strong and independent predictor of adverse events and can be used for risk stratification in patients with AMI treated with PCI. CI - (c) 2023 Tang, Peng, Yao, Liu, Zhang, Zhong, She, Liu, Tang, Fu and Zhang. FAU - Tang, Yijin AU - Tang Y AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China. FAU - Peng, Siling AU - Peng S AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China. FAU - Yao, Hui-Ling AU - Yao HL AD - Department of General Medicine, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Hunan Normal University, Changsha, China. FAU - Liu, Zhibin AU - Liu Z AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China. FAU - Zhang, Liang AU - Zhang L AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China. FAU - Zhong, Changqing AU - Zhong C AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China. FAU - She, Chang AU - She C AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China. FAU - Liu, Wei AU - Liu W AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China. FAU - Tang, Yi AU - Tang Y AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China. FAU - Fu, Qinghua AU - Fu Q AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China. FAU - Zhang, Yi AU - Zhang Y AD - Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China. LA - eng PT - Journal Article DEP - 20230901 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC10505662 OTO - NOTNLM OT - acute myocardial infarction OT - left atrial function index OT - percutaneous coronary intervention OT - prognosis OT - transthoracic echocardiography COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/09/20 06:42 MHDA- 2023/09/20 06:43 PMCR- 2023/01/01 CRDT- 2023/09/20 03:48 PHST- 2022/09/14 00:00 [received] PHST- 2023/08/11 00:00 [accepted] PHST- 2023/09/20 06:43 [medline] PHST- 2023/09/20 06:42 [pubmed] PHST- 2023/09/20 03:48 [entrez] PHST- 2023/01/01 00:00 [pmc-release] AID - 10.3389/fcvm.2023.1043775 [doi] PST - epublish SO - Front Cardiovasc Med. 2023 Sep 1;10:1043775. doi: 10.3389/fcvm.2023.1043775. eCollection 2023.