PMID- 37729697
OWN - NLM
STAT- Publisher
LR  - 20231012
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 265
DP  - 2023 Oct 15
TI  - Deposition of secondary organic aerosol in human lung model: Effect of 
      photochemically aged aerosol on human respiratory system.
PG  - 115497
LID - S0147-6513(23)01001-1 [pii]
LID - 10.1016/j.ecoenv.2023.115497 [doi]
AB  - Ultrafine particles (UFP) of Secondary Organic Aerosol (SOA) penetrate deep into 
      the human respiratory system and exert fatal effects on human health. However, 
      there is little data on the potential deposited doses of UFP-generated SOA in the 
      human respiratory tract. This study is to estimate the fraction of aerosol 
      deposition using a multiple-path-particle-dosimetry (MPPD) model. For relevancy 
      of real life, the model employed measured concentrations of toluene-derived fresh 
      and aged SOA produced within serially connected smog chamber and PAM-OFR 
      (Potential Aerosol Mass-Oxidation Flow Reactor) under atmospheric environmental 
      conditions (NOx and relative humidity). The number concentrations and chemical 
      composition of fresh and aged aerosols produced within the chambers were measured 
      using Scanning Mobility Particle Sizer (SMPS) and High-Resolution Time-of-Flight 
      Aerosol Mass Spectrometer (HR-ToF-AMS), while the morphology of individual 
      particles was analyzed using Scanning Electron Microscopy (SEM). The number 
      concentration of aged SOA-w/s was more than double compared to that of fresh 
      SOA-w/s (maximum reached after 10 h) with its size less than 100 nm. The O:C 
      ratio for aged SOA-w/s were 0.96 and 1.15 depending on RH (0.96 at 3% RH and 1.15 
      at 50% RH), and individual spherical particles containing water were present in 
      agglomerates with its size of less than 1 microm. In all inhalable fresh and aged SOA 
      produced in the two chambers, 5-22% of aerosol is deposited in the Head airways, 
      4-8% in the tracheobronchial, and 8-34% in the alveolar regions. The predominant 
      deposition of the aged aerosol occurred in the alveoli (in the generation 20th 
      lobe), and the deposition faction in the alveoli was 2-3 times higher in the 
      children group than the adults group. This study presented a quantitative 
      exposure assessment of SOA generated under a realistic simulation and suggested 
      the possibility of evaluating long-term exposure to SOA and potential health 
      effects by determining the potential inhalable aerosol doses and the fraction of 
      deposition in the human respiratory system.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Oh, Hyeon-Ju
AU  - Oh HJ
AD  - Institute of Health and Environment, Seoul National University, Seoul 08826, 
      South Korea. Electronic address: smju26@snu.ac.kr.
FAU - Chen, Yanfang
AU  - Chen Y
AD  - Department of Environmental Health Sciences, Graduate School of Public Health, 
      Seoul National University, Seoul 08826, South Korea.
FAU - Kim, Hwajin
AU  - Kim H
AD  - Department of Environmental Health Sciences, Graduate School of Public Health, 
      Seoul National University, Seoul 08826, South Korea. Electronic address: 
      khj0116@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20230918
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
SB  - IM
OTO - NOTNLM
OT  - Aged aerosol
OT  - Inhalable aerosol
OT  - Respiratory deposition
OT  - Secondary organic aerosol
OT  - Smog chamber
OT  - Toluene
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/09/21 00:42
MHDA- 2023/09/21 00:42
CRDT- 2023/09/20 18:01
PHST- 2023/07/11 00:00 [received]
PHST- 2023/09/12 00:00 [revised]
PHST- 2023/09/17 00:00 [accepted]
PHST- 2023/09/21 00:42 [pubmed]
PHST- 2023/09/21 00:42 [medline]
PHST- 2023/09/20 18:01 [entrez]
AID - S0147-6513(23)01001-1 [pii]
AID - 10.1016/j.ecoenv.2023.115497 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2023 Oct 15;265:115497. doi: 
      10.1016/j.ecoenv.2023.115497. Epub 2023 Sep 18.