PMID- 37730486 OWN - NLM STAT- MEDLINE DCOM- 20231117 LR - 20240319 IS - 1879-3061 (Electronic) IS - 1043-2760 (Linking) VI - 34 IP - 12 DP - 2023 Dec TI - Road map for personalized exercise medicine in T2DM. PG - 789-798 LID - S1043-2760(23)00166-2 [pii] LID - 10.1016/j.tem.2023.08.013 [doi] AB - The number of patients with type 2 diabetes mellitus (T2DM) is rising at an alarming rate. Regular physical activity and exercise are cornerstones in the therapy of T2DM. While a one-size-fits-all approach fails to account for many between-subject differences, the use of personalized exercise medicine has the potential of optimizing health outcomes. Here, a road map for personalized exercise therapy targeted at patients with T2DM is presented. It considers secondary complications, glucose management, response heterogeneity, and other relevant factors that might influence the effectiveness of exercise as medicine, taking exercise-medication-diet interactions, as well as feasibility and acceptance into account. Furthermore, the potential of artificial intelligence and machine learning-based applications in assisting sports therapists to find appropriate exercise programs is outlined. CI - Copyright (c) 2023 Elsevier Ltd. All rights reserved. FAU - Brinkmann, Christian AU - Brinkmann C AD - Institute of Cardiovascular Research and Sport Medicine, Department of Preventive and Rehabilitative Sport Medicine, German Sport University Cologne, Cologne, Germany; Department of Fitness & Health, IST University of Applied Sciences, Dusseldorf, Germany. Electronic address: ch.brinkmann@gmx.net. LA - eng PT - Journal Article PT - Review DEP - 20230918 PL - United States TA - Trends Endocrinol Metab JT - Trends in endocrinology and metabolism: TEM JID - 9001516 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/therapy MH - Artificial Intelligence MH - Exercise MH - Exercise Therapy MH - Diet OTO - NOTNLM OT - artificial intelligence OT - individualized training OT - personalized exercise medicine OT - training planning OT - type 2 diabetes mellitus COIS- Declaration of interests C.B. is a member of the Abbott advisory board and has received honoraria from Novo Nordisk. The companies had no role in preparation of the manuscript or decision to publish. EDAT- 2023/09/21 00:42 MHDA- 2023/11/17 15:25 CRDT- 2023/09/20 21:54 PHST- 2023/07/09 00:00 [received] PHST- 2023/08/20 00:00 [revised] PHST- 2023/08/21 00:00 [accepted] PHST- 2023/11/17 15:25 [medline] PHST- 2023/09/21 00:42 [pubmed] PHST- 2023/09/20 21:54 [entrez] AID - S1043-2760(23)00166-2 [pii] AID - 10.1016/j.tem.2023.08.013 [doi] PST - ppublish SO - Trends Endocrinol Metab. 2023 Dec;34(12):789-798. doi: 10.1016/j.tem.2023.08.013. Epub 2023 Sep 18.