PMID- 37731087
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 2193-8210 (Print)
IS  - 2190-9172 (Electronic)
VI  - 13
IP  - 11
DP  - 2023 Nov
TI  - Responsiveness and Minimal Clinically Important Difference of the Infants and 
      Toddlers Dermatology Quality of Life Questionnaire.
PG  - 2879-2893
LID - 10.1007/s13555-023-01022-x [doi]
AB  - BACKGROUND: The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) is 
      the dermatology-specific proxy health-related quality of life (HRQoL) instrument 
      for children from birth to 4 years. The aim of the present study was to confirm 
      the responsiveness and establish minimal clinically important difference (MCID) 
      for the InToDermQoL. METHODS: Parents of children with skin diseases were asked 
      to fill in the InToDermQoL at the initial visit (T1) and subsequent consultation 
      (T2). We hypothesized that correlations between change scores of the InToDermQoL 
      and change scores of global assessment of clinical severity by dermatologists and 
      by patients' parents should be above 0.3. The receiver operating characteristic 
      (ROC) curves method was also used for confirmation of responsiveness and 
      determination of MCIDs of the InToDermQoL. The area under the ROC curve (AUC) was 
      used as an indicator of responsiveness. RESULTS: Results of 442 patients were 
      included. Correlations between change scores of age-specific versions of the 
      InToDermQoL and change scores of global assessment of clinical severity by 
      dermatologists and by patients' parents were above 0.3 (0.46-0.74). AUCs for 
      age-specific versions of the InToDermQoL were acceptable (above 0.7) or excellent 
      (above 0.8). Estimated MCIDs for the InToDermQoL were as follows: 3 points of 
      total score change for 0-11 months, 5 for 1-2 years and 3 or 4 for 3-4 years 
      version. Estimated MCIDs for the InToDermQoL version for 1-2-year-old children 
      was higher than MCIDs for the 3-4-year-old version despite the higher number of 
      items in the latter. Therefore a MCID of 5 was recommended for both these 
      versions. CONCLUSIONS: Responsiveness for all age-specific versions of the 
      InToDermQoL questionnaire was confirmed. MCIDs for the InToDermQoL are proposed 
      as follows: 3-point change of the total score for age version 0-11 months and 
      5-point for the age versions 1-2 years and 3-4 years.
CI  - (c) 2023. The Author(s).
FAU - Chernyshov, Pavel V
AU  - Chernyshov PV
AUID- ORCID: 0000-0001-7275-4651
AD  - Department of Dermatology and Venereology, National Medical University, Bulvar 
      Shevchenko, 13, Kiev, 01601, Ukraine. chernyshovpavel@ukr.net.
FAU - Marron, Servando E
AU  - Marron SE
AUID- ORCID: 0000-0001-5632-0351
AD  - Department of Dermatology, Aragon Psychodermatology Research Group (GAI+PD), 
      University Hospital Miguel Servet, Zaragoza, Spain.
FAU - Koumaki, Dimitra
AU  - Koumaki D
AUID- ORCID: 0000-0001-7074-2374
AD  - Department of Dermatology and Venereology, University Hospital of Heraklion, 
      Heraklion, Crete, Greece.
FAU - Pustisek, Nives
AU  - Pustisek N
AD  - Children's Hospital Zagreb, Zagreb, Croatia.
FAU - Manolache, Liana
AU  - Manolache L
AUID- ORCID: 0000-0003-2357-4229
AD  - Dermatology, Dali Medical, Bucharest, Romania.
FAU - Salavastru, Carmen
AU  - Salavastru C
AUID- ORCID: 0000-0002-3160-9826
AD  - Department of Paediatric Dermatology, Colentina Clinical Hospital, "Carol Davila" 
      University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Suru, Alina
AU  - Suru A
AD  - Department of Paediatric Dermatology, Colentina Clinical Hospital, "Carol Davila" 
      University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Sendrea, Adelina
AU  - Sendrea A
AD  - Department of Paediatric Dermatology, Colentina Clinical Hospital, "Carol Davila" 
      University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Svyatenko, Tetiana
AU  - Svyatenko T
AUID- ORCID: 0000-0003-4303-2937
AD  - Department of Skin and Venereal Diseases, Dnipro State Medical University, 
      Dnipro, Ukraine.
FAU - Statkevych, Olha
AU  - Statkevych O
AD  - Department of Skin and Venereal Diseases, Dnipro State Medical University, 
      Dnipro, Ukraine.
FAU - Boffa, Michael J
AU  - Boffa MJ
AD  - Department of Dermatology, Mater Dei Hospital, Msida, Malta.
FAU - Grech, Sara Borg
AU  - Grech SB
AD  - Department of Dermatology, Mater Dei Hospital, Msida, Malta.
FAU - Zemskov, Sergii
AU  - Zemskov S
AUID- ORCID: 0000-0002-5039-1324
AD  - Department of General Surgery, Bogomolets National Medical University, Kiev, 
      Ukraine.
FAU - Kuts, Volodymyr V
AU  - Kuts VV
AUID- ORCID: 0000-0002-4434-7298
AD  - Department of Information and Computer Technologies, State Organization "National 
      Institute of Phthisiology and Pulmonology Named After F.G. Yanovsky, National 
      Academy of Medical Sciences of Ukraine", Kiev, Ukraine.
FAU - Lishchynskyi, Pavlo
AU  - Lishchynskyi P
AUID- ORCID: 0000-0003-3586-0468
AD  - Ukrainian Scientific and Practical Center of Endocrine Surgery, Transplantation 
      of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kiev, 
      Ukraine.
FAU - Chernyshov, Andrii V
AU  - Chernyshov AV
AUID- ORCID: 0000-0002-9564-759X
AD  - Department of Cellular Radiobiology, State Institution "National Research Center 
      for Radiation Medicine of National Academy of Medical Sciences of Ukraine", Kiev, 
      Ukraine.
FAU - Tomas-Aragones, Lucia
AU  - Tomas-Aragones L
AUID- ORCID: 0000-0001-5891-628X
AD  - Department of Psychology, University of Zaragoza, Zaragoza, Spain.
LA  - eng
PT  - Journal Article
DEP - 20230920
PL  - Switzerland
TA  - Dermatol Ther (Heidelb)
JT  - Dermatology and therapy
JID - 101590450
PMC - PMC10613170
OTO - NOTNLM
OT  - Children
OT  - Dermatology
OT  - Infants and Toddlers Dermatology Quality of Life
OT  - Minimal clinically important difference
OT  - Quality of life
OT  - Responsiveness
COIS- The authors have nothing to disclose.
EDAT- 2023/09/21 06:42
MHDA- 2023/09/21 06:43
PMCR- 2023/09/20
CRDT- 2023/09/21 00:18
PHST- 2023/07/19 00:00 [received]
PHST- 2023/08/23 00:00 [accepted]
PHST- 2023/09/21 06:43 [medline]
PHST- 2023/09/21 06:42 [pubmed]
PHST- 2023/09/21 00:18 [entrez]
PHST- 2023/09/20 00:00 [pmc-release]
AID - 10.1007/s13555-023-01022-x [pii]
AID - 1022 [pii]
AID - 10.1007/s13555-023-01022-x [doi]
PST - ppublish
SO  - Dermatol Ther (Heidelb). 2023 Nov;13(11):2879-2893. doi: 
      10.1007/s13555-023-01022-x. Epub 2023 Sep 20.