PMID- 37731289 OWN - NLM STAT- MEDLINE DCOM- 20231102 LR - 20231102 IS - 1756-185X (Electronic) IS - 1756-1841 (Linking) VI - 26 IP - 11 DP - 2023 Nov TI - Cartilage and bone loss in premenopausal women with rheumatoid arthritis: Radiological and laboratory assessments. PG - 2195-2205 LID - 10.1111/1756-185X.14915 [doi] AB - INTRODUCTION: To investigate the radiological and laboratory features of bone and cartilage losses in premenopausal women with rheumatoid arthritis (RA). METHODS: This case-control study is the continuation of a study that was conducted on 48 women with RA and 48 matched healthy volunteers. All RA patients were previously subjected to clinical examination, disease activity assessment using the 28-joint Disease Activity Score (DAS28) and Clinical Disease Activity Index (CDAI), serological tests, dual-energy X-ray absorptiometry measuring bone mineral density (BMD), and plain X-ray of both hands. Added to these, matrix metalloproteinase 3 (MMP-3) and cartilage oligomeric matrix protein (COMP) were measured by enzyme-linked immunosorbent assay. RESULTS: There were statistically significant differences between patients and controls regarding COMP and MMP-3, being higher in patients (p < .001). COMP and MMP-3 have significant positive correlation with serum levels of anti-cyclic citrullinated peptide (anti-CCP) and anti-carbamylated protein (anti-CarP). The original Sharp erosion score was positively correlated with the serum level of the studied antibodies and disease duration, but no significant correlation was found with either COMP, MMP-3, or DAS-28. Spine BMD and Z score were negatively correlated with disease activity and anti-CarP. There were significant positive relationhsips between indices of local cartilage and bone loss and the indices of systemic bone loss. MMP-3 had no correlation with indices of local cartilage and bone loss and disease activity scores. CONCLUSIONS: The pathogenic mechanism of hand joint damage involved the three studied autoantibodies namely, rheumatoid factor, anti-CCP and anti-CarP antibodies. Anti-CarP antibody was involved in the reduction of BMD of the spine. The association between systemic osteoporosis and hand joint damage pointed to a common pathogenic mechanism. CI - (c) 2023 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. FAU - Elsawy, Noha A AU - Elsawy NA AD - Department of Physical Medicine Rheumatology and Rehabilitation, Faculty of Medicine Alexandria University, Alexandria, Egypt. FAU - Ghazala, Rasha A AU - Ghazala RA AD - Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt. FAU - Elnemr, Rehab AU - Elnemr R AUID- ORCID: 0000-0001-9604-4937 AD - Department of Physical Medicine Rheumatology and Rehabilitation, Faculty of Medicine Alexandria University, Alexandria, Egypt. LA - eng PT - Journal Article DEP - 20230920 PL - England TA - Int J Rheum Dis JT - International journal of rheumatic diseases JID - 101474930 RN - EC 3.4.24.17 (Matrix Metalloproteinase 3) RN - 0 (Anti-Citrullinated Protein Antibodies) RN - 0 (Autoantibodies) SB - IM MH - Humans MH - Female MH - *Matrix Metalloproteinase 3 MH - Case-Control Studies MH - Anti-Citrullinated Protein Antibodies MH - *Arthritis, Rheumatoid/diagnostic imaging MH - Autoantibodies MH - Bone Density MH - Cartilage/pathology OTO - NOTNLM OT - bone loss OT - disability OT - erosions OT - fatigue OT - rheumatoid arthritis EDAT- 2023/09/21 06:42 MHDA- 2023/11/02 12:47 CRDT- 2023/09/21 02:12 PHST- 2023/08/24 00:00 [revised] PHST- 2023/07/02 00:00 [received] PHST- 2023/09/03 00:00 [accepted] PHST- 2023/11/02 12:47 [medline] PHST- 2023/09/21 06:42 [pubmed] PHST- 2023/09/21 02:12 [entrez] AID - 10.1111/1756-185X.14915 [doi] PST - ppublish SO - Int J Rheum Dis. 2023 Nov;26(11):2195-2205. doi: 10.1111/1756-185X.14915. Epub 2023 Sep 20.