PMID- 37732312
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230922
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 17
DP  - 2023
TI  - Development of circadian neurovascular function and its implications.
PG  - 1196606
LID - 10.3389/fnins.2023.1196606 [doi]
LID - 1196606
AB  - The neurovascular system forms the interface between the tissue of the central 
      nervous system (CNS) and circulating blood. It plays a critical role in 
      regulating movement of ions, small molecules, and cellular regulators into and 
      out of brain tissue and in sustaining brain health. The neurovascular unit (NVU), 
      the cells that form the structural and functional link between cells of the brain 
      and the vasculature, maintains the blood-brain interface (BBI), controls cerebral 
      blood flow, and surveils for injury. The neurovascular system is dynamic; it 
      undergoes tight regulation of biochemical and cellular interactions to balance 
      and support brain function. Development of an intrinsic circadian clock enables 
      the NVU to anticipate rhythmic changes in brain activity and body physiology that 
      occur over the day-night cycle. The development of circadian neurovascular 
      function involves multiple cell types. We address the functional aspects of the 
      circadian clock in the components of the NVU and their effects in regulating 
      neurovascular physiology, including BBI permeability, cerebral blood flow, and 
      inflammation. Disrupting the circadian clock impairs a number of physiological 
      processes associated with the NVU, many of which are correlated with an increased 
      risk of dysfunction and disease. Consequently, understanding the cell biology and 
      physiology of the NVU is critical to diminishing consequences of impaired 
      neurovascular function, including cerebral bleeding and neurodegeneration.
CI  - Copyright (c) 2023 Mitchell and Gillette.
FAU - Mitchell, Jennifer W
AU  - Mitchell JW
AD  - Department of Cell and Developmental Biology, University of Illinois 
      Urbana-Champaign, Urbana, IL, United States.
AD  - Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, United 
      States.
AD  - Beckman Institute for Advanced Science and Technology, University of Illinois 
      Urbana-Champaign, Urbana, IL, United States.
FAU - Gillette, Martha U
AU  - Gillette MU
AD  - Department of Cell and Developmental Biology, University of Illinois 
      Urbana-Champaign, Urbana, IL, United States.
AD  - Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, United 
      States.
AD  - Beckman Institute for Advanced Science and Technology, University of Illinois 
      Urbana-Champaign, Urbana, IL, United States.
AD  - Department of Molecular and Integrative Physiology, University of Illinois 
      Urbana-Champaign, Urbana, IL, United States.
AD  - Carle-Illinois College of Medicine, University of Illinois Urbana-Champaign, 
      Urbana, IL, United States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230905
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC10507717
OTO - NOTNLM
OT  - blood-brain interface
OT  - circadian rhythm disruption
OT  - clock
OT  - neuroendothelial
OT  - tight junctions
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/09/21 06:42
MHDA- 2023/09/21 06:43
PMCR- 2023/01/01
CRDT- 2023/09/21 04:16
PHST- 2023/03/30 00:00 [received]
PHST- 2023/08/14 00:00 [accepted]
PHST- 2023/09/21 06:43 [medline]
PHST- 2023/09/21 06:42 [pubmed]
PHST- 2023/09/21 04:16 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2023.1196606 [doi]
PST - epublish
SO  - Front Neurosci. 2023 Sep 5;17:1196606. doi: 10.3389/fnins.2023.1196606. 
      eCollection 2023.