PMID- 37732463
OWN - NLM
STAT- MEDLINE
DCOM- 20231122
LR  - 20231122
IS  - 1467-789X (Electronic)
IS  - 1467-7881 (Linking)
VI  - 24
IP  - 12
DP  - 2023 Dec
TI  - m(6) A mRNA methylation: Biological features, mechanisms, and therapeutic 
      potentials in type 2 diabetes mellitus.
PG  - e13639
LID - 10.1111/obr.13639 [doi]
AB  - As the most common internal post-transcriptional RNA modification in eukaryotic 
      cells, N6-methyladenosine (m(6) A) performs a dynamic and reversible role in a 
      variety of biological processes mediated by methyltransferases (writers), 
      demethylases (erasers), and m(6) A binding proteins (readers). M(6) A methylation 
      enables transcriptome conversion in different signals that regulate various 
      physiological activities and organ development. Over the past few years, emerging 
      studies have identified that mRNA m(6) A regulators defect in beta-cell leads to 
      abnormal regulation of the target mRNAs, thereby resulting in beta-cell dysfunction 
      and loss of beta-cell identity and mass, which are strongly associated with type 2 
      diabetes mellitus (T2DM) pathogenesis. Also, mRNA m(6) A modification has been 
      implicated with insulin resistance in muscles, fat, and liver cells/tissues. In 
      this review, we elaborate on the biological features of m(6) A methylation; 
      provide a comprehensive overview of the underlying mechanisms that how it 
      controls beta-cell function, identity, and mass as well as insulin resistance; 
      highlight its connections to glucose metabolism and lipid metabolism linking to 
      T2DM; and further discuss its role in diabetes complications and its therapeutic 
      potentials for T2DM diagnosis and treatment.
CI  - (c) 2023 World Obesity Federation.
FAU - Ren, Yuanyuan
AU  - Ren Y
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Li, Zi
AU  - Li Z
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Li, Jiaoyu
AU  - Li J
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Liang, Rui
AU  - Liang R
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Bai, Yiduo
AU  - Bai Y
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Yang, Yafang
AU  - Yang Y
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Tang, Qian
AU  - Tang Q
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Fu, Yaolei
AU  - Fu Y
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Zhang, Xiaobo
AU  - Zhang X
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
FAU - Yu, Yi
AU  - Yu Y
AUID- ORCID: 0000-0003-1445-1702
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
AD  - School of Medicine, Northwest University, Xi'an, Shaanxi, China.
FAU - Xiong, Yuyan
AU  - Xiong Y
AUID- ORCID: 0000-0001-7623-7109
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry 
      of Education, Faculty of Life Sciences and Medicine, College of Life Sciences, 
      Northwest University, Xi'an, Shaanxi, China.
AD  - School of Medicine, Northwest University, Xi'an, Shaanxi, China.
LA  - eng
GR  - 82103589/National Natural Science Foundation of China/
GR  - 2023-JC-YB-705/Natural Science Foundation of Shaanxi Province/
GR  - 20JG034/Special Scientific Research Plan for Emergency Public Health Safety of 
      Shaanxi Provincial Department of Education/
GR  - CX2023055/Graduate Innovation Program of Northwestern University/
PT  - Journal Article
PT  - Review
DEP - 20230921
PL  - England
TA  - Obes Rev
JT  - Obesity reviews : an official journal of the International Association for the 
      Study of Obesity
JID - 100897395
RN  - EC 2.1.1.- (Methyltransferases)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Humans
MH  - Methylation
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - *Insulin Resistance/genetics
MH  - Methyltransferases/genetics/metabolism
MH  - RNA, Messenger/genetics/metabolism
OTO - NOTNLM
OT  - m6A methylation
OT  - mechanisms
OT  - therapeutic potentials
OT  - type 2 diabetes mellitus
EDAT- 2023/09/21 06:42
MHDA- 2023/11/22 06:43
CRDT- 2023/09/21 05:33
PHST- 2023/08/10 00:00 [revised]
PHST- 2022/07/26 00:00 [received]
PHST- 2023/08/27 00:00 [accepted]
PHST- 2023/11/22 06:43 [medline]
PHST- 2023/09/21 06:42 [pubmed]
PHST- 2023/09/21 05:33 [entrez]
AID - 10.1111/obr.13639 [doi]
PST - ppublish
SO  - Obes Rev. 2023 Dec;24(12):e13639. doi: 10.1111/obr.13639. Epub 2023 Sep 21.