PMID- 37733041
OWN - NLM
STAT- Publisher
LR  - 20230921
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
DP  - 2023 Sep 21
TI  - When MRI would be useful in patients without evidence of sacroiliitis on 
      radiographs?
LID - 10.1007/s00296-023-05468-2 [doi]
AB  - We aimed to identify when magnetic resonance imaging (MRI) would be useful to 
      diagnose patients with suspected axial spondyloarthropathy (AxSpA) without 
      evidence of sacroiliitis on radiographs. We retrospectively reviewed electronic 
      medical records of patients who underwent pelvis MRI after radiographs at the 
      rheumatology clinic in a single tertiary center in Korea. Patients underwent 
      imaging from January 2020 to July 2022. We collected data including complete 
      blood count, erythrocyte sedimentation rate, C-reactive protein (CRP), human 
      leukocyte antigen (HLA)-B27, history of acute anterior uveitis (AAU), peripheral 
      arthritis, dactylitis, inflammatory bowel disease (IBD), enthesopathy, and 
      psoriasis. A total of 105 patients who showed no evidence of sacroiliitis on 
      radiographs were included. The median age of patients was 41.0 years, and 44.8% 
      were male. Of them, 34 showed sacroiliitis on MRI (group 1), and 71 showed no 
      evidence of sacroiliitis even on MRI (group 2). Known AxSpA-related clinical 
      features including AAU, peripheral arthritis, dactylitis, IBD, enthesopathy, and 
      psoriasis were not different between the two groups. HLA-B27 positivity (79.4% 
      vs. 40.0%, p < 0.001), median white blood cell count (7700 vs. 6300, p = 0.007), 
      mean platelet count (307.7 +/- 69.7 vs. 265.3 +/- 68.9 x 10(3)/microL, p = 0.005), and 
      median CRP level (0.38 vs. 0.10, p = 0.001) showed significant differences 
      between the two groups. In a multivariate analysis, HLA-B27 positivity and 
      platelet count were significantly associated with sacroiliitis on MRI. In our 
      cohort, sacroiliitis was observed on MRI in one-third of patients without 
      radiographic evidence. MRI could be recommended to evaluate sacroiliitis in 
      patients with positive HLA-B27 and a high platelet count.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Lee, Yeo-Jin
AU  - Lee YJ
AUID- ORCID: 0000-0002-1050-673X
AD  - Department of Rheumatology, Asan Medical Center, University of Ulsan College of 
      Medicine, 88, Olympic-ro 43-gil, Seoul, 05505, Republic of Korea.
FAU - Lee, Sang Hoon
AU  - Lee SH
AUID- ORCID: 0000-0002-7089-536X
AD  - Department of Radiology, Research Institute of Radiology, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Ahn, Soo-Min
AU  - Ahn SM
AUID- ORCID: 0000-0002-9213-9768
AD  - Department of Rheumatology, Asan Medical Center, University of Ulsan College of 
      Medicine, 88, Olympic-ro 43-gil, Seoul, 05505, Republic of Korea.
FAU - Hong, Seokchan
AU  - Hong S
AUID- ORCID: 0000-0001-8722-3124
AD  - Department of Rheumatology, Asan Medical Center, University of Ulsan College of 
      Medicine, 88, Olympic-ro 43-gil, Seoul, 05505, Republic of Korea.
FAU - Oh, Ji-Seon
AU  - Oh JS
AUID- ORCID: 0000-0002-0205-6492
AD  - Department of Information Medicine, Big Data Research Center, Asan Medical 
      Center, Seoul, Republic of Korea.
FAU - Lee, Chang-Keun
AU  - Lee CK
AUID- ORCID: 0000-0003-3653-7515
AD  - Department of Rheumatology, Asan Medical Center, University of Ulsan College of 
      Medicine, 88, Olympic-ro 43-gil, Seoul, 05505, Republic of Korea.
FAU - Yoo, Bin
AU  - Yoo B
AUID- ORCID: 0000-0002-1836-5273
AD  - Department of Rheumatology, Asan Medical Center, University of Ulsan College of 
      Medicine, 88, Olympic-ro 43-gil, Seoul, 05505, Republic of Korea.
FAU - Kim, Yong-Gil
AU  - Kim YG
AUID- ORCID: 0000-0002-8029-7355
AD  - Department of Rheumatology, Asan Medical Center, University of Ulsan College of 
      Medicine, 88, Olympic-ro 43-gil, Seoul, 05505, Republic of Korea. 
      bestmd2000@amc.seoul.kr.
LA  - eng
GR  - 2022 IF0013/Asan Institute for Life Sciences, Asan Medical Center/
PT  - Journal Article
DEP - 20230921
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
SB  - IM
OTO - NOTNLM
OT  - HLA-B27
OT  - MRI
OT  - Non-radiographic axial spondyloarthropathy
OT  - Radiograph
EDAT- 2023/09/21 12:44
MHDA- 2023/09/21 12:44
CRDT- 2023/09/21 11:04
PHST- 2023/07/05 00:00 [received]
PHST- 2023/09/10 00:00 [accepted]
PHST- 2023/09/21 12:44 [medline]
PHST- 2023/09/21 12:44 [pubmed]
PHST- 2023/09/21 11:04 [entrez]
AID - 10.1007/s00296-023-05468-2 [pii]
AID - 10.1007/s00296-023-05468-2 [doi]
PST - aheadofprint
SO  - Rheumatol Int. 2023 Sep 21. doi: 10.1007/s00296-023-05468-2.