PMID- 37738146 OWN - NLM STAT- MEDLINE DCOM- 20240502 LR - 20240510 IS - 1943-7730 (Electronic) IS - 0007-5027 (Linking) VI - 55 IP - 3 DP - 2024 May 2 TI - An observational association study between maternal homocysteine and pregnancy complications or perinatal outcomes with established trimester-specific reference intervals in pregnant women. PG - 355-360 LID - 10.1093/labmed/lmad092 [doi] AB - BACKGROUND: Elevated homocysteine (Hcy) level during pregnancy is positively associated with various gestational-specific diseases. However, there is no uniform standard for the reference interval (RI) of Hcy in pregnancy. METHODS: From January 2017 to January 2019, 14,530 singleton pregnant women registered at our institute were included for the establishment of trimester-specific RIs of Hcy with both the nonparametric approach and the indirect Hoffmann method, followed by pregnancy outcome association analysis conducted with logistic regression. RESULTS: The serum Hcy level in the nonpregnant group was significantly higher than that of pregnant women. A relatively decreased Hcy concentration was observed in the second trimester when compared with that of the first or third trimester. The direct RIs of Hcy in the first or third, and second trimesters were 4.6 to 8.0 mmol/L (merged) and 4.0 to 6.4 mmol/L, respectively, which showed no significant difference compared with the RI derived from the indirect Hoffmann method. In the subsequent risk analysis, the first trimester Hcy was found to be negatively associated with GDM development; whereas the third trimester Hcy conferred increased risk of postpartum hemorrhage after delivery. CONCLUSION: Having established trimester-specific RIs, our study sheds light on the complicated roles of Hcy in pregnancy-related complications. CI - (c) The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Tang, Guodong AU - Tang G AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Department of Clinical Laboratory, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China. FAU - Su, Shaofei AU - Su S AUID- ORCID: 0000-0002-9299-8853 AD - Central Laboratory, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Lu, Yifan AU - Lu Y AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Meng, Lanlan AU - Meng L AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Han, Lican AU - Han L AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Xu, Zhengwen AU - Xu Z AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Liu, Lin AU - Liu L AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Zeng, Jiazi AU - Zeng J AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Chen, Lu AU - Chen L AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Wang, Jing AU - Wang J AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Zhang, Yue AU - Zhang Y AD - Information Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Zhai, Yanhong AU - Zhai Y AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Cao, Zheng AU - Cao Z AUID- ORCID: 0000-0002-0968-1864 AD - Department of Laboratory Medicine, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. AD - Center of Clinical Mass Spectrometry, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. LA - eng GR - CCMU2022ZKYXZ006/Training Fund for Open Projects at Clinical Institutes and Departments of Capital Medical University/ GR - PX2020060/Beijing Municipal Administration of Hospitals Incubating Program/ GR - Beijing Obstetrics and Gynecology Hospital/ GR - Capital Medical University/ GR - XKGG201802/Beijing Maternal and Child Health Care Hospital "Discipline Backbone" Plan Special Funds/ PT - Journal Article PT - Observational Study PL - England TA - Lab Med JT - Laboratory medicine JID - 0250641 RN - 0LVT1QZ0BA (Homocysteine) SB - IM MH - Humans MH - Pregnancy MH - Female MH - *Homocysteine/blood MH - Adult MH - *Pregnancy Complications/blood MH - *Pregnancy Outcome/epidemiology MH - *Pregnancy Trimesters/blood MH - Reference Values MH - Young Adult OTO - NOTNLM OT - cohort study OT - homocysteine OT - outcome OT - population-based OT - pregnancy OT - reference interval EDAT- 2023/09/22 18:42 MHDA- 2024/05/02 13:02 CRDT- 2023/09/22 12:43 PHST- 2024/05/02 13:02 [medline] PHST- 2023/09/22 18:42 [pubmed] PHST- 2023/09/22 12:43 [entrez] AID - 7278939 [pii] AID - 10.1093/labmed/lmad092 [doi] PST - ppublish SO - Lab Med. 2024 May 2;55(3):355-360. doi: 10.1093/labmed/lmad092.