PMID- 37738762
OWN - NLM
STAT- Publisher
LR  - 20231017
IS  - 1873-3557 (Electronic)
IS  - 1386-1425 (Linking)
VI  - 304
DP  - 2024 Jan 5
TI  - Raman spectroscopic diagnosis of blast-induced traumatic brain injury in rats 
      combined with machine learning.
PG  - 123419
LID - S1386-1425(23)01104-6 [pii]
LID - 10.1016/j.saa.2023.123419 [doi]
AB  - Blast-induced traumatic brain injury (bTBI) is a kind of nervous system disease, 
      which results in a major health and economic problem to society. However, the 
      rapid and label-free detection method with high sensitivity is still in great 
      demand for the diagnosis of bTBI, especially for mild bTBI. In this paper, we 
      report a new strategy for bTBI diagnosis through hippocampus and hypothalamus 
      tissues based on Raman spectroscopy. The spectral characteristics of hippocampus 
      and hypothalamus tissues of experimental bTBI in rats have been investigated for 
      mild and moderate degrees at 3 h, 6 h, 24 h, 48 h, 72 h after blast exposure. The 
      results show that the Raman spectra of mild and moderate bTBIs in 300-1700 cm(-1) 
      and 2800-3000 cm(-1) regions exhibit significant differences at different time 
      points compared with the control group. The main reason is the content change of 
      proteins and lipids in hippocampus and hypothalamus tissues after bTBI. Moreover, 
      four machine learning algorithms are used to automatically identify mild and 
      moderate bTBIs at different time points (a total of 11 groups). The highest 
      diagnostic accuracies are up to 95.3% and 88.5% based on Raman spectra of 
      hippocampus and hypothalamus tissue, respectively. In addition, the 
      classification performance of linear discriminant analysis classifier has been 
      improved after data fusion. It is suggested that there has great potential as an 
      alternative method for high-sensitive, rapid, label-free, economical diagnosis of 
      bTBI.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Ge, Meilan
AU  - Ge M
AD  - School of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, China; Key Laboratory of Optoelectronics Information 
      Technology (Ministry of Education), Tianjin University, Tianjin 300072, China.
FAU - Wang, Yuye
AU  - Wang Y
AD  - School of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, China; Key Laboratory of Optoelectronics Information 
      Technology (Ministry of Education), Tianjin University, Tianjin 300072, China. 
      Electronic address: yuyewang@tju.edu.cn.
FAU - Wu, Tong
AU  - Wu T
AD  - School of Marine Science and Technology, Tianjin University, Tianjin 300072, 
      China.
FAU - Li, Haibin
AU  - Li H
AD  - School of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, China; Key Laboratory of Optoelectronics Information 
      Technology (Ministry of Education), Tianjin University, Tianjin 300072, China.
FAU - Yang, Chuanyan
AU  - Yang C
AD  - Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, 
      Third Military Medical University (Army Medical University), Chongqing 400038, 
      China.
FAU - Wang, Zelong
AU  - Wang Z
AD  - School of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, China; Key Laboratory of Optoelectronics Information 
      Technology (Ministry of Education), Tianjin University, Tianjin 300072, China.
FAU - Mu, Ning
AU  - Mu N
AD  - Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, 
      Third Military Medical University (Army Medical University), Chongqing 400038, 
      China.
FAU - Chen, Tunan
AU  - Chen T
AD  - Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, 
      Third Military Medical University (Army Medical University), Chongqing 400038, 
      China.
FAU - Xu, Degang
AU  - Xu D
AD  - School of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, China; Key Laboratory of Optoelectronics Information 
      Technology (Ministry of Education), Tianjin University, Tianjin 300072, China.
FAU - Feng, Hua
AU  - Feng H
AD  - Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, 
      Third Military Medical University (Army Medical University), Chongqing 400038, 
      China.
FAU - Yao, Jianquan
AU  - Yao J
AD  - School of Precision Instruments and Optoelectronics Engineering, Tianjin 
      University, Tianjin 300072, China; Key Laboratory of Optoelectronics Information 
      Technology (Ministry of Education), Tianjin University, Tianjin 300072, China.
LA  - eng
PT  - Journal Article
DEP - 20230916
PL  - England
TA  - Spectrochim Acta A Mol Biomol Spectrosc
JT  - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
JID - 9602533
SB  - IM
OTO - NOTNLM
OT  - Blast-induced traumatic injury (bTBI)
OT  - Classification
OT  - Different degree
OT  - Different time points
OT  - Raman spectroscopy
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/09/23 11:42
MHDA- 2023/09/23 11:42
CRDT- 2023/09/22 18:03
PHST- 2023/04/27 00:00 [received]
PHST- 2023/08/12 00:00 [revised]
PHST- 2023/09/14 00:00 [accepted]
PHST- 2023/09/23 11:42 [pubmed]
PHST- 2023/09/23 11:42 [medline]
PHST- 2023/09/22 18:03 [entrez]
AID - S1386-1425(23)01104-6 [pii]
AID - 10.1016/j.saa.2023.123419 [doi]
PST - ppublish
SO  - Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jan 5;304:123419. doi: 
      10.1016/j.saa.2023.123419. Epub 2023 Sep 16.