PMID- 37739157
OWN - NLM
STAT- Publisher
LR  - 20231020
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 128
DP  - 2024 Jan 10
TI  - Unilateral anterior capsulotomy combined with deep brain stimulation for 
      Parkinson's disease psychosis and motor dysfunctions.
PG  - 110865
LID - S0278-5846(23)00151-3 [pii]
LID - 10.1016/j.pnpbp.2023.110865 [doi]
AB  - Psychosis is a frequent and debilitating non-motor symptom of Parkinson's disease 
      (PD). This study aimed to evaluate the availability of unilateral anterior 
      capsulotomy combined with subthalamic nucleus deep brain stimulation (STN-DBS) in 
      managing advanced PD patients comorbid with psychosis. Five advanced PD patients 
      with psychosis who had been treated with unilateral anterior capsulotomy combined 
      with bilateral STN-DBS were assessed. The positive subscore of the Positive and 
      Negative Syndrome Scale (PANSS) and the Unified Parkinson's Disease Rating Scale 
      III (UPDRS-III) were used to assess the efficacy parameter of psychosis and the 
      improved motor symptoms, respectively. The quality of life (QoL) was accessed by 
      an 8-item Parkinson's disease Questionnaire (PDQ-8). Clinical outcome assessments 
      were performed at baseline and follow-ups after one or two years. Significant 
      improvement was observed in PD patients during follow-up after the combined 
      treatment. The positive subscore of PANSS improved by 13.4 (5.7) (mean (SD), 
      p = 0.006). Item P1 (delusions) and Item P3 (hallucinations) of the PANSS 
      improved by 5.0 (0.71) (p < 0.0001) and 3.6 (0.89) (p = 0.0008), respectively. 
      Furthermore, the motor symptoms improved by 32.4 (5.7) (UPDRS-III, p = 0.0002), 
      and the QoL improved by 6.4 (3.8) (PDQ-8, p = 0.021). No significant side effects 
      or complications occurred during the study. For advanced PD patients with 
      refractory psychosis, unilateral anterior capsulotomy combined with bilateral 
      STN-DBS improved PD psychosis and motor dysfunction, providing an effective 
      therapeutic option for such patients.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Dai, Lulin
AU  - Dai L
AD  - Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of 
      Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 
      Hangzhou, China.
FAU - Pan, Yixin
AU  - Pan Y
AD  - Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Huang, Peng
AU  - Huang P
AD  - Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zhang, Chencheng
AU  - Zhang C
AD  - Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Sun, Bomin
AU  - Sun B
AD  - Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic 
      address: sbm11224@rjh.com.cn.
FAU - Li, Dianyou
AU  - Li D
AD  - Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic 
      address: ldy11483@rjh.com.cn.
LA  - eng
PT  - Journal Article
DEP - 20230920
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
OTO - NOTNLM
OT  - Anterior capsulotomy
OT  - Deep brain stimulation
OT  - Parkinson's disease
OT  - Parkinson's disease psychosis
COIS- Declaration of Competing Interest All authors report no conflicts of interest.
EDAT- 2023/09/23 11:42
MHDA- 2023/09/23 11:42
CRDT- 2023/09/22 19:15
PHST- 2023/05/29 00:00 [received]
PHST- 2023/09/07 00:00 [revised]
PHST- 2023/09/19 00:00 [accepted]
PHST- 2023/09/23 11:42 [pubmed]
PHST- 2023/09/23 11:42 [medline]
PHST- 2023/09/22 19:15 [entrez]
AID - S0278-5846(23)00151-3 [pii]
AID - 10.1016/j.pnpbp.2023.110865 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2024 Jan 10;128:110865. doi: 
      10.1016/j.pnpbp.2023.110865. Epub 2023 Sep 20.