PMID- 37739166
OWN - NLM
STAT- Publisher
LR  - 20231009
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 332
DP  - 2023 Nov 1
TI  - The influence of gut microbiota on circulating inflammatory cytokines and host: A 
      Mendelian randomization study with meta-analysis.
PG  - 122105
LID - S0024-3205(23)00740-3 [pii]
LID - 10.1016/j.lfs.2023.122105 [doi]
AB  - AIMS: The gut microbiota has been found to be altered in different inflammatory 
      disorders, but its involvement in the regulation of inflammatory cytokines 
      remains unclear. Therefore, this study aimed to investigate the impacts of gut 
      microbiota on circulating inflammatory cytokines and their potential roles in 
      host diseases. MAIN METHODS: Two-sample Mendelian randomization (MR) analyses 
      were conducted using summary-level data from genome-wide association studies 
      (GWAS) to identify significant causal associations between 196 gut microbiota and 
      41 inflammatory cytokines. Meta-analysis was applied to test the robustness of 
      the results. Enrichment analyses of identified cytokines were further utilized to 
      infer the effects of gut microbiota on the host. KEY FINDINGS: The MR analyses 
      and meta-analyses identified the following significant causal associations: 
      phylum Euryarchaeota on interleukin-2 (IL-2) (beta(IVW) = 0.085, P = 1.5 x 10(-2)) 
      and interleukin-8 (IL-8) (beta(IVW) = 0.065, P = 4.1 x 10(-2)), phylum Tenericutes 
      and class Mollicutes on macrophage inflammatory protein 1a (MIP1a) 
      (beta(IVW) = -0.142, P = 7.0 x 10(-3)), class Bacilli on hepatocyte growth factor 
      (HGF) (beta(IVW) = -0.106, P = 2.5 x 10(-2)), order Enterobacteriales on monocyte 
      chemoattractant protein-1 (MCP1) (beta(IVW) = 0.182, P = 1.8 x 10(-2)), and genus 
      Lachnospiraceae NC2004 group on TNF-related apoptosis-inducing ligand (TRAIL) 
      (beta(IVW) = -0.207, P = 6.0 x 10(-4)). Enrichment analyses suggested that phylum 
      Euryarchaeota and order Enterobacteriales might be risk factors for certain 
      autoimmune diseases and neoplasms, while the phylum Tenericutes may have a 
      protective effect. SIGNIFICANCE: This study represents the first evidence 
      confirming the causal effect of specific gut microbial taxa on circulating 
      inflammatory cytokines and sheds light on their potential roles in the 
      development and progression of various host diseases.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Xue, Fan
AU  - Xue F
AD  - Department of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Dalian 
      University, Dalian 116001, Liaoning Province, China.
FAU - He, Zheng
AU  - He Z
AD  - Department of Radiation Oncology, The First Hospital of China Medical University, 
      Shenyang 110001, Liaoning Province, China. Electronic address: zhe@cmu.edu.cn.
FAU - Zhuang, De-Zheng
AU  - Zhuang DZ
AD  - Department of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Dalian 
      University, Dalian 116001, Liaoning Province, China.
FAU - Lin, Feng
AU  - Lin F
AD  - Department of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Dalian 
      University, Dalian 116001, Liaoning Province, China. Electronic address: 
      linfeng200612@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230921
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
SB  - IM
OTO - NOTNLM
OT  - Cytokine
OT  - Gut microbiota
OT  - Inflammatory disease
OT  - Mendelian randomization
COIS- Declaration of competing interest The authors have no relevant financial or 
      non-financial interests to disclose.
EDAT- 2023/09/23 11:42
MHDA- 2023/09/23 11:42
CRDT- 2023/09/22 19:15
PHST- 2023/07/28 00:00 [received]
PHST- 2023/09/15 00:00 [revised]
PHST- 2023/09/17 00:00 [accepted]
PHST- 2023/09/23 11:42 [pubmed]
PHST- 2023/09/23 11:42 [medline]
PHST- 2023/09/22 19:15 [entrez]
AID - S0024-3205(23)00740-3 [pii]
AID - 10.1016/j.lfs.2023.122105 [doi]
PST - ppublish
SO  - Life Sci. 2023 Nov 1;332:122105. doi: 10.1016/j.lfs.2023.122105. Epub 2023 Sep 
      21.