PMID- 37740359
OWN - NLM
STAT- Publisher
LR  - 20231010
IS  - 1364-548X (Electronic)
IS  - 1359-7345 (Linking)
VI  - 59
IP  - 81
DP  - 2023 Oct 10
TI  - The design strategy for pillararene based active targeted drug delivery systems.
PG  - 12091-12099
LID - 10.1039/d3cc04021f [doi]
AB  - Pillararenes have columnar architectures with electron-rich cavities to endow 
      themselves with unique host-guest complexation capability. Easy structural 
      modifiability facilitates them to be used in many applications. Currently, 
      pillararene based drug delivery systems (DDSs) have been developed as a powerful 
      tool for precise diagnosis and treatment of cancer. Various functional guest 
      molecules could be integrated with pillararenes to construct nanomaterials for 
      cancer chemotherapy, phototherapy and chemodynamic therapy. In order to improve 
      cancer therapy efficacy, active targeted DDSs have become particularly important. 
      Benefiting from the good host-guest properties and structural variability of 
      pillararenes, tumor targeting groups could be easily introduced into pillararene 
      based DDSs to realize precise drug delivery at tumor sites. In this feature 
      article, we provide a comprehensive summary of the present design strategy for 
      pillararene based active targeted DDSs, which can be classified into three types 
      namely host-guest complexation, charge reversal and targeted group modified 
      pillararenes. Some important examples are selected to for a detailed discussion 
      on their respective strengths and weaknesses.
FAU - Lu, Bing
AU  - Lu B
AUID- ORCID: 0000-0001-9385-3931
AD  - School of Chemistry and Chemical Engineering, Nantong University, Nantong, 
      Jiangsu, 226019, P. R. China. 2020028lubing@ntu.edu.cn.
FAU - Xia, Jiachen
AU  - Xia J
AD  - School of Chemistry and Chemical Engineering, Nantong University, Nantong, 
      Jiangsu, 226019, P. R. China. 2020028lubing@ntu.edu.cn.
FAU - Huang, Yuying
AU  - Huang Y
AD  - School of Chemistry and Chemical Engineering, Nantong University, Nantong, 
      Jiangsu, 226019, P. R. China. 2020028lubing@ntu.edu.cn.
FAU - Yao, Yong
AU  - Yao Y
AUID- ORCID: 0000-0001-5566-4822
AD  - School of Chemistry and Chemical Engineering, Nantong University, Nantong, 
      Jiangsu, 226019, P. R. China. 2020028lubing@ntu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231010
PL  - England
TA  - Chem Commun (Camb)
JT  - Chemical communications (Cambridge, England)
JID - 9610838
SB  - IM
EDAT- 2023/09/23 11:44
MHDA- 2023/09/23 11:44
CRDT- 2023/09/23 00:25
PHST- 2023/09/23 11:44 [pubmed]
PHST- 2023/09/23 11:44 [medline]
PHST- 2023/09/23 00:25 [entrez]
AID - 10.1039/d3cc04021f [doi]
PST - epublish
SO  - Chem Commun (Camb). 2023 Oct 10;59(81):12091-12099. doi: 10.1039/d3cc04021f.