PMID- 37740806
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231030
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 49
DP  - 2023 Oct
TI  - Association of urinary heavy metal combined exposure with periodontitis among US 
      adults from NHANES 2011-2014.
PG  - 107887-107898
LID - 10.1007/s11356-023-29888-6 [doi]
AB  - Some heavy metals are associated with periodontitis; whereas most of these 
      associations have focused on individual metal, there are no specific studies on 
      the effects of combined heavy metal exposure on periodontitis. We conducted an 
      analysis on the association between urinary heavy metal exposure and 
      periodontitis in participants aged 30 years and older using multiple logistic 
      regression and Bayesian kernel machine regression (BKMR). This analysis was 
      performed on data from the National Health and Nutrition Examination Survey from 
      2011 to 2014. The study found that using logistic regression, the 4th quartile of 
      urinary lead and molybdenum and the 3rd quartile of urinary strontium were 
      positively associated with periodontitis compared to the reference quartile after 
      adjusting for covariates. Odds ratio (OR) with 95% confidence interval (CI) was 
      1.738 (1.069-2.826), 1.515 (1.025-2.239), and 1.498 (1.010-2.222), respectively. 
      The 3rd and 4th quartiles of urinary cobalt were negatively associated with 
      periodontitis, and their ORs and 95% CIs were 0.639 (0.438-0.934) and 0.571 
      (0.377-0.964), respectively. The BKMR model showed that urinary barium, lead, and 
      molybdenum were positively associated with periodontitis in a range of 
      concentrations and urinary cobalt, manganese, tin, and strontium were negatively 
      correlated with periodontitis. Furthermore, the overall association between 
      urinary heavy metals and periodontitis was positive. Our study provides evidence 
      for an association between exposure to multiple urinary heavy metals and 
      periodontitis. However, further longitudinal studies are needed to explore the 
      specific mechanisms involved.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Li, Zhen-Hua
AU  - Li ZH
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China.
FAU - Li, Jiong
AU  - Li J
AD  - Key Lab. of Oral Diseases Research of Anhui Province, College & Hospital of 
      Stomatology, Anhui Medical University, Hefei, 230032, China.
FAU - Mao, Yi-Cheng
AU  - Mao YC
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China.
FAU - Zhao, Jia-Wen
AU  - Zhao JW
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China.
FAU - Hu, Hui-Yu
AU  - Hu HY
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China.
FAU - Zhang, Sun
AU  - Zhang S
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China.
FAU - Liu, Zhe-Ye
AU  - Liu ZY
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China.
FAU - Liu, Xue-Jie
AU  - Liu XJ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China.
FAU - Huang, Kai
AU  - Huang K
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China.
AD  - Department of Hospital Infection Prevention and Control, The Second Affiliated 
      Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.
FAU - Hu, Cheng-Yang
AU  - Hu CY
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China.
AD  - Department of Humanistic Medicine, School of Humanistic Medicine, Anhui Medical 
      University, 81 Meishan Road, Hefei, 230032, China.
FAU - Zhang, Xiu-Jun
AU  - Zhang XJ
AUID- ORCID: 0000-0002-8123-185X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, China. 
      zhangxiujun@ahmu.edu.cn.
AD  - Key Lab. of Oral Diseases Research of Anhui Province, College & Hospital of 
      Stomatology, Anhui Medical University, Hefei, 230032, China. 
      zhangxiujun@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230923
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 81AH48963U (Molybdenum)
RN  - 0 (Metals, Heavy)
RN  - 3G0H8C9362 (Cobalt)
RN  - YZS2RPE8LE (Strontium)
RN  - 00BH33GNGH (Cadmium)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Nutrition Surveys
MH  - Molybdenum
MH  - Bayes Theorem
MH  - *Metals, Heavy
MH  - Cobalt
MH  - *Periodontitis/epidemiology
MH  - Strontium
MH  - Cadmium
OTO - NOTNLM
OT  - Heavy metals
OT  - NHANES
OT  - Periodontitis
EDAT- 2023/09/23 20:42
MHDA- 2023/10/30 06:46
CRDT- 2023/09/23 11:06
PHST- 2023/07/01 00:00 [received]
PHST- 2023/09/11 00:00 [accepted]
PHST- 2023/10/30 06:46 [medline]
PHST- 2023/09/23 20:42 [pubmed]
PHST- 2023/09/23 11:06 [entrez]
AID - 10.1007/s11356-023-29888-6 [pii]
AID - 10.1007/s11356-023-29888-6 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Oct;30(49):107887-107898. doi: 
      10.1007/s11356-023-29888-6. Epub 2023 Sep 23.