PMID- 37742791
OWN - NLM
STAT- MEDLINE
DCOM- 20231106
LR  - 20231106
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 256
DP  - 2023 Nov
TI  - Intravenous immunoglobulin in kidney transplantation: Mechanisms of action, 
      clinical applications, adverse effects, and hyperimmune globulin.
PG  - 109782
LID - S1521-6616(23)00545-4 [pii]
LID - 10.1016/j.clim.2023.109782 [doi]
AB  - Intravenous immunoglobulin (IVIG) has been developed for over 40 years. The 
      mechanisms of action of IVIG are complex and diverse, and there may be multiple 
      mechanisms that combine to influence it. IVIG has been used in kidney 
      transplantation for desensitization, treatment of antibody-mediated rejection, 
      and ABO-incompatible transplantation. and treatment or prevention of some 
      infectious diseases. Hyperimmune globulins such as cytomegalovirus hyperimmune 
      globulin (CMV-IG) and hepatitis B hyperimmune globulin (HBIG) have also been used 
      to protect against cytomegalovirus and hepatitis B virus, respectively. However, 
      IVIG is also associated with some rare but serious adverse effects and some 
      application risks, and clinicians need to weigh the pros and cons and develop 
      individualized treatment programs to benefit more patients. This review will 
      provide an overview of the multiple mechanisms of action, clinical applications, 
      adverse effects, and prophylactic measures of IVIG, and hyperimmune globulin will 
      also be introduced in it.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Hou, Yi-Bo
AU  - Hou YB
AD  - Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology; Key Laboratory of Organ 
      Transplantation, Ministry of Education; NHC Key Laboratory of Organ 
      Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of 
      Medical Sciences, Wuhan 430030, China.
FAU - Chang, Sheng
AU  - Chang S
AD  - Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology; Key Laboratory of Organ 
      Transplantation, Ministry of Education; NHC Key Laboratory of Organ 
      Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of 
      Medical Sciences, Wuhan 430030, China.
FAU - Chen, Song
AU  - Chen S
AD  - Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology; Key Laboratory of Organ 
      Transplantation, Ministry of Education; NHC Key Laboratory of Organ 
      Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of 
      Medical Sciences, Wuhan 430030, China.
FAU - Zhang, Wei-Jie
AU  - Zhang WJ
AD  - Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology; Key Laboratory of Organ 
      Transplantation, Ministry of Education; NHC Key Laboratory of Organ 
      Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of 
      Medical Sciences, Wuhan 430030, China. Electronic address: wjzhangtj@126.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230922
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Humans
MH  - Immunoglobulins, Intravenous/adverse effects
MH  - *Kidney Transplantation
MH  - *Cytomegalovirus Infections
MH  - Cytomegalovirus
OTO - NOTNLM
OT  - Adverse effect
OT  - Hyperimmune globulin
OT  - Intravenous immunoglobulin
OT  - Kidney transplantation
OT  - Mechanism of action
EDAT- 2023/09/25 00:42
MHDA- 2023/11/06 06:42
CRDT- 2023/09/24 19:15
PHST- 2023/07/24 00:00 [received]
PHST- 2023/09/11 00:00 [revised]
PHST- 2023/09/20 00:00 [accepted]
PHST- 2023/11/06 06:42 [medline]
PHST- 2023/09/25 00:42 [pubmed]
PHST- 2023/09/24 19:15 [entrez]
AID - S1521-6616(23)00545-4 [pii]
AID - 10.1016/j.clim.2023.109782 [doi]
PST - ppublish
SO  - Clin Immunol. 2023 Nov;256:109782. doi: 10.1016/j.clim.2023.109782. Epub 2023 Sep 
      22.