PMID- 37743657
OWN - NLM
STAT- MEDLINE
DCOM- 20230926
LR  - 20231005
IS  - 2001-1326 (Electronic)
IS  - 2001-1326 (Linking)
VI  - 13
IP  - 9
DP  - 2023 Sep
TI  - Inflammatory proteins are associated with mortality in a middle-aged diverse 
      cohort.
PG  - e1412
LID - 10.1002/ctm2.1412 [doi]
LID - e1412
AB  - BACKGROUND: Recent data indicate a decline in overall longevity in the United 
      States. Even prior to the COVID-19 pandemic, an increase in midlife mortality 
      rates had been reported. Life expectancy disparities have persisted in the United 
      States for racial and ethnic groups and for individuals living at low 
      socioeconomic status. These continued trends in mortality indicate the importance 
      of examining biomarkers of mortality at midlife in at-risk populations. 
      Circulating levels of cytokines and inflammatory markers reflect systemic chronic 
      inflammation, which is a well-known driver of many age-related diseases. METHODS: 
      In this study, we examined the relationship of nine different inflammatory 
      proteins with mortality in a middle-aged socioeconomically diverse cohort of 
      African-American and White men and women (n = 1122; mean age = 47.8 years). 
      RESULTS: We found significant differences in inflammatory-related protein serum 
      levels between African-American and White middle-aged adults. E-selectin and 
      fibrinogen were significantly higher in African-American adults. IFN-gamma, TNF-alpha 
      trimer, monocyte chemoattractant protein-1 (MCP-1), soluble receptor for advanced 
      glycation end-products (sRAGE) and P-selectin were significantly higher in White 
      participants compared to African-American participants. Higher levels of 
      E-selectin, MCP-1 and P-selectin were associated with a higher mortality risk. 
      Furthermore, there was a significant interaction between sex and IL-6 with 
      mortality. IL-6 levels were associated with an increased risk of mortality, an 
      association that was significantly greater in women than men. In addition, White 
      participants with high levels of sRAGE had significantly higher survival 
      probability than White participants with low levels of sRAGE, while 
      African-American participants had similar survival probabilities across sRAGE 
      levels. CONCLUSIONS: These results suggest that circulating inflammatory markers 
      can be utilized as indicators of midlife mortality risk in a socioeconomically 
      diverse cohort of African-American and White individuals.
CI  - Published 2023. This article is a U.S. Government work and is in the public 
      domain in the USA. Clinical and Translational Medicine published by John Wiley & 
      Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
FAU - Noren Hooten, Nicole
AU  - Noren Hooten N
AUID- ORCID: 0000-0002-1683-3838
AD  - Laboratory of Epidemiology and Population Science National Institute on Aging, 
      National Institutes of Health, Baltimore, Maryland, USA.
FAU - Mode, Nicolle A
AU  - Mode NA
AD  - Laboratory of Epidemiology and Population Science National Institute on Aging, 
      National Institutes of Health, Baltimore, Maryland, USA.
FAU - Allotey, Samuel
AU  - Allotey S
AD  - Laboratory of Epidemiology and Population Science National Institute on Aging, 
      National Institutes of Health, Baltimore, Maryland, USA.
AD  - Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
FAU - Ezike, Ngozi
AU  - Ezike N
AD  - Laboratory of Epidemiology and Population Science National Institute on Aging, 
      National Institutes of Health, Baltimore, Maryland, USA.
FAU - Zonderman, Alan B
AU  - Zonderman AB
AD  - Laboratory of Epidemiology and Population Science National Institute on Aging, 
      National Institutes of Health, Baltimore, Maryland, USA.
FAU - Evans, Michele K
AU  - Evans MK
AUID- ORCID: 0000-0002-8546-2831
AD  - Laboratory of Epidemiology and Population Science National Institute on Aging, 
      National Institutes of Health, Baltimore, Maryland, USA.
LA  - eng
GR  - AG 000513/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Clin Transl Med
JT  - Clinical and translational medicine
JID - 101597971
RN  - 0 (E-Selectin)
RN  - 0 (P-Selectin)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptor for Advanced Glycation End Products)
SB  - IM
MH  - Adult
MH  - Male
MH  - Middle Aged
MH  - Humans
MH  - Female
MH  - *E-Selectin
MH  - P-Selectin
MH  - Interleukin-6
MH  - Pandemics
MH  - Receptor for Advanced Glycation End Products
MH  - *COVID-19
PMC - PMC10518496
OTO - NOTNLM
OT  - inflammation
OT  - midlife
OT  - mortality
OT  - race
COIS- The authors declare that they have no competing interests.
EDAT- 2023/09/25 06:43
MHDA- 2023/09/26 13:42
PMCR- 2023/09/24
CRDT- 2023/09/25 01:54
PHST- 2023/08/29 00:00 [revised]
PHST- 2023/05/30 00:00 [received]
PHST- 2023/09/04 00:00 [accepted]
PHST- 2023/09/26 13:42 [medline]
PHST- 2023/09/25 06:43 [pubmed]
PHST- 2023/09/25 01:54 [entrez]
PHST- 2023/09/24 00:00 [pmc-release]
AID - CTM21412 [pii]
AID - 10.1002/ctm2.1412 [doi]
PST - ppublish
SO  - Clin Transl Med. 2023 Sep;13(9):e1412. doi: 10.1002/ctm2.1412.