PMID- 37745893
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230926
IS  - 2666-2450 (Electronic)
IS  - 2666-2450 (Linking)
VI  - 5
DP  - 2023
TI  - Subjective vs informant-reported cognitive complaints have differential clinical 
      significance in covert cerebral small vessel disease.
PG  - 100182
LID - 10.1016/j.cccb.2023.100182 [doi]
LID - 100182
AB  - OBJECTIVE: Subjective cognitive complaints are common in patients with cerebral 
      small vessel disease (cSVD), yet their relationship with informant evaluations, 
      objective cognitive functions and severity of brain changes are poorly 
      understood. We studied the associations of subjective and informant reports with 
      findings from comprehensive neuropsychological assessment and brain MRI. METHOD: 
      In the Helsinki SVD Study, 152 older adults with varying degrees of white matter 
      hyperintensities (WMH) but without stroke or dementia were classified as having 
      normal cognition or mild cognitive impairment (MCI) based on neuropsychological 
      criteria. The measures also included continuous domain scores for memory and 
      executive functions. Cognitive complaints were evaluated with the subjective and 
      informant versions of the Prospective and Retrospective Memory Questionnaire 
      (PRMQ) and Dysexecutive Questionnaire (DEX); functional abilities with the 
      Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL); and 
      depressive symptoms with the Geriatric Depression Scale (GDS-15). RESULTS: 
      Subjective cognitive complaints correlated significantly with informant reports 
      (r=0.40-0.50, p<0.001). After controlling for demographics, subjective and 
      informant DEX and PRMQ were not related to MCI, memory or executive functions. 
      Instead, subjective DEX and PRMQ significantly associated with GDS-15 and 
      informant DEX and PRMQ with WMH volume and A-IADL. CONCLUSIONS: Neither 
      subjective nor informant-reported cognitive complaints associated with objective 
      cognitive performance. Informant-evaluations were related to functional 
      impairment and more severe WMH, whereas subjective complaints only associated 
      with mild depressive symptoms. These findings suggest that awareness of cognitive 
      impairment may be limited in early-stage cSVD and highlight the value of 
      informant assessments in the identification of patients with functional 
      impairment.
CI  - (c) 2023 The Authors.
FAU - Arola, Anne
AU  - Arola A
AD  - Division of Neuropsychology, HUS Neurocenter, Helsinki University Hospital and 
      University of Helsinki, Helsinki, Finland.
AD  - Department of Psychology and Logopedics, Faculty of Medicine, University of 
      Helsinki, Helsinki, Finland.
FAU - Laakso, Hanna M
AU  - Laakso HM
AD  - Division of Neuropsychology, HUS Neurocenter, Helsinki University Hospital and 
      University of Helsinki, Helsinki, Finland.
AD  - Department of Psychology and Logopedics, Faculty of Medicine, University of 
      Helsinki, Helsinki, Finland.
FAU - Heinonen, Heidi
AU  - Heinonen H
AD  - Division of Neuropsychology, HUS Neurocenter, Helsinki University Hospital and 
      University of Helsinki, Helsinki, Finland.
FAU - Pitkanen, Johanna
AU  - Pitkanen J
AD  - Department of Neurology, Helsinki University Hospital and University of Helsinki, 
      Helsinki, Finland.
FAU - Ahlstrom, Matti
AU  - Ahlstrom M
AD  - Department of Neurology, Helsinki University Hospital and University of Helsinki, 
      Helsinki, Finland.
FAU - Lempiainen, Juha
AU  - Lempiainen J
AD  - Department of Neurology, Helsinki University Hospital and University of Helsinki, 
      Helsinki, Finland.
FAU - Paajanen, Teemu
AU  - Paajanen T
AD  - Work ability and working careers, Finnish Institute of Occupational Health, 
      Helsinki, Finland.
FAU - Virkkala, Jussi
AU  - Virkkala J
AD  - Department of Neurophysiology, University of Helsinki and Helsinki University 
      Hospital, Helsinki, Finland.
FAU - Koikkalainen, Juha
AU  - Koikkalainen J
AD  - Combinostics Ltd, Tampere, Finland.
AD  - Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
FAU - Lotjonen, Jyrki
AU  - Lotjonen J
AD  - Combinostics Ltd, Tampere, Finland.
AD  - Department of Neuroscience and Biomedical Engineering, School of Science, Aalto 
      University, Espoo, Finland.
FAU - Korvenoja, Antti
AU  - Korvenoja A
AD  - Medical Imaging Center, Radiology, Helsinki University Hospital and University of 
      Helsinki, Helsinki, Finland.
FAU - Melkas, Susanna
AU  - Melkas S
AD  - Department of Neurology, Helsinki University Hospital and University of Helsinki, 
      Helsinki, Finland.
FAU - Jokinen, Hanna
AU  - Jokinen H
AD  - Division of Neuropsychology, HUS Neurocenter, Helsinki University Hospital and 
      University of Helsinki, Helsinki, Finland.
AD  - Department of Psychology and Logopedics, Faculty of Medicine, University of 
      Helsinki, Helsinki, Finland.
LA  - eng
PT  - Journal Article
DEP - 20230909
PL  - Netherlands
TA  - Cereb Circ Cogn Behav
JT  - Cerebral circulation - cognition and behavior
JID - 101774849
PMC - PMC10514088
OTO - NOTNLM
OT  - Awareness of cognitive impairment
OT  - Cerebral small vessel disease
OT  - Cognition
OT  - Mild cognitive impairment
OT  - Subjective cognitive complaints
OT  - White matter hyperintensities
COIS- MA has received a personal fee for educational event from Merck KGaA. AK has 
      received payment for expert testimony from the Finnish National Insurance Centre, 
      for a neuroradiologist expert testimony on a court of justice, support for travel 
      from Helsinki University Hospital and is the board member of the Finnish 
      Radiological Society. JK and JL are shareholders at Combinostics Ltd. TP is a 
      board member at the Finnish Brain Council, the Finnish Neuropsychological 
      Society, and the Finnish Alzheimer's Disease Research Society. The other authors 
      report no competing of interests.
EDAT- 2023/09/25 06:41
MHDA- 2023/09/25 06:42
PMCR- 2023/09/09
CRDT- 2023/09/25 05:08
PHST- 2023/04/24 00:00 [received]
PHST- 2023/07/30 00:00 [revised]
PHST- 2023/09/04 00:00 [accepted]
PHST- 2023/09/25 06:42 [medline]
PHST- 2023/09/25 06:41 [pubmed]
PHST- 2023/09/25 05:08 [entrez]
PHST- 2023/09/09 00:00 [pmc-release]
AID - S2666-2450(23)00026-0 [pii]
AID - 100182 [pii]
AID - 10.1016/j.cccb.2023.100182 [doi]
PST - epublish
SO  - Cereb Circ Cogn Behav. 2023 Sep 9;5:100182. doi: 10.1016/j.cccb.2023.100182. 
      eCollection 2023.