PMID- 37745942
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230926
IS  - 2772-7076 (Electronic)
IS  - 2772-7076 (Linking)
VI  - 9
DP  - 2023 Dec
TI  - Hookworm infection induces glycometabolic modulation in South Indian individuals 
      with type 2 diabetes.
PG  - 18-24
LID - 10.1016/j.ijregi.2023.08.009 [doi]
AB  - OBJECTIVES: A number of epidemiological studies have demonstrated that there is 
      an inverse relationship between helminth infections and diabetes mellitus, 
      suggesting that helminth infection may have a positive effect on type 2 diabetes 
      mellitus (T2DM). However, the association between hookworm infection and T2DM has 
      barely been studied. Hence, we aimed to investigate and analyze the interaction 
      and association between hookworm infection and T2DM. METHODS: We examined the 
      effect of hookworm infection on biochemical parameters, including plasma random 
      blood glucose, glycated hemoglobin, and the plasma levels of pancreatic hormones, 
      incretins, and adipokines in individuals with T2DM with (INF, n = 35) or without 
      (UN, n = 35) hookworm infection. Moreover, we re-evaluated these analyte 
      concentrations in a subset of INF individuals 6 months following anthelmintic 
      therapy. RESULTS: Compared to UN individuals, INF individuals had significantly 
      lowered levels of random blood glucose and glycated hemoglobin. INF individuals 
      also exhibited significantly diminished levels of adiponectin, adipsin, 
      C-peptide, insulin, and glucagon compared to UN individuals. In contrast, INF 
      individuals displayed substantially elevated levels of visfatin and incretins 
      compared to UN individuals. Interestingly, this effect was not seen following 
      anthelmintic treatment. CONCLUSION: Our study findings indicate that concomitant 
      hookworm infection exerts a beneficial effect on glycometabolic parameters in 
      T2DM.
CI  - (c) 2023 The Authors.
FAU - Dasan, Bindu
AU  - Dasan B
AD  - National Institutes of Health-National Institute of Allergy and Infectious 
      Diseases-International Center for Excellence in Research, Chennai, India.
FAU - Rajamanickam, Anuradha
AU  - Rajamanickam A
AD  - National Institutes of Health-National Institute of Allergy and Infectious 
      Diseases-International Center for Excellence in Research, Chennai, India.
FAU - Munisankar, Saravanan
AU  - Munisankar S
AD  - National Institutes of Health-National Institute of Allergy and Infectious 
      Diseases-International Center for Excellence in Research, Chennai, India.
FAU - Menon, Pradeep A
AU  - Menon PA
AD  - National Institute for Research in Tuberculosis, Chennai, India.
FAU - Ahamed, S Fayaz
AU  - Ahamed SF
AD  - National Institutes of Health-National Institute of Allergy and Infectious 
      Diseases-International Center for Excellence in Research, Chennai, India.
FAU - Nott, Sujatha
AU  - Nott S
AD  - Infectious Diseases, Dignity Health, Chandler, USA.
FAU - Babu, Subash
AU  - Babu S
AD  - National Institutes of Health-National Institute of Allergy and Infectious 
      Diseases-International Center for Excellence in Research, Chennai, India.
AD  - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Bethesda, USA.
LA  - eng
PT  - Journal Article
DEP - 20230829
PL  - England
TA  - IJID Reg
JT  - IJID regions
JID - 9918418183106676
PMC - PMC10514067
OTO - NOTNLM
OT  - Hookworm infection
OT  - Incretins, and adipokines
OT  - Pancreatic hormones
OT  - Type 2 diabetes mellitus
COIS- The authors have no competing interests to declare.
EDAT- 2023/09/25 06:42
MHDA- 2023/09/25 06:43
PMCR- 2023/08/29
CRDT- 2023/09/25 05:09
PHST- 2023/06/15 00:00 [received]
PHST- 2023/08/21 00:00 [revised]
PHST- 2023/08/26 00:00 [accepted]
PHST- 2023/09/25 06:43 [medline]
PHST- 2023/09/25 06:42 [pubmed]
PHST- 2023/09/25 05:09 [entrez]
PHST- 2023/08/29 00:00 [pmc-release]
AID - S2772-7076(23)00090-5 [pii]
AID - 10.1016/j.ijregi.2023.08.009 [doi]
PST - epublish
SO  - IJID Reg. 2023 Aug 29;9:18-24. doi: 10.1016/j.ijregi.2023.08.009. eCollection 
      2023 Dec.