PMID- 37749514
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231121
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Sep 25
TI  - The prognostic role of coagulation markers in the progression and metastasis of 
      laryngeal squamous cell carcinoma.
PG  - 901
LID - 10.1186/s12885-023-11381-5 [doi]
LID - 901
AB  - BACKGROUND: The application of coagulation-related markers in laryngeal squamous 
      cell carcinoma(LSCC) remains unclear. This study explored the prognostic role of 
      coagulation markers in the progression and metastasis of LSCC. METHODS: 
      Coagulation markers of patients with LSCC receiving surgery in the Second 
      Affiliated Hospital of Fujian Medical University in China, from January 2013 to 
      May 2022 were retrospectively analyzed and compared with those of contemporary 
      patients with benign laryngeal diseases. The relationship between 
      clinicopathological features of LSCC and coagulation markers was analyzed with 
      the chi-square and rank sum tests. The ROC curve analysis was utilized to 
      evaluate the diagnostic efficacy of seven coagulation markers for LSCC and its 
      different clinicopathological features, and to find the optimal cutoff value of 
      each coagulation marker. RESULTS: 303 patients with LSCC and 533 patients with 
      benign laryngeal diseases were included in the present analysis. Compared to the 
      control group, prothrombin time (PT) (p < 0.001), activated partial 
      thromboplastin time (APTT) (p = 0.001), and Fib (p < 0.001) in patients with LSCC 
      were significantly higher, while mean platelet volume (MPV) (p < 0.001) was 
      significantly shorter. Significant increases were detected in PT (Z = 14.342, 
      p = 0.002), Fib (Z = 25.985, p < 0.001), platelet count (PC) (Z = 12.768, 
      p = 0.005), PCT (Z = 9.178, p = 0.027), MPV (F = 2.948, p = 0.033) in T4 stage. 
      Fib had the highest prognostic value among the seven coagulation markers in 
      different T stages (AUC = 0.676, p < 0.001), N stages (AUC = 0.717, p < 0.001), 
      tumor stage (AUC = 0.665, p < 0.001), differentiation degree (AUC = 0.579, 
      p = 0.022), and neurovascular invasion (AUC = 0.651, p = 0.007). Fib (Z = 25.832, 
      p < 0.001), PC (Z = 23.842, p < 0.001), and PCT (Z = 20.15, p < 0.001) in N1 and 
      N3 stages were significantly higher than in N0 stage. PT (Z = 12.174, p = 0.007), 
      Fib (Z = 23.873, p < 0.001), PC (Z = 17.785, p < 0.001), and PCT (Z = 14.693, 
      p = 0.002) were significantly higher in stage IV than in stage I and II. APTT 
      (Z=-1.983, p = 0.047), Fib (Z=-2.68, p = 0.007), PC (Z=-2.723, p = 0.006), and 
      PCT (Z=-2.592, p = 0.01) increased significantly when the tumor invaded 
      neurovascular tissue. CONCLUSIONS: Coagulation markers have the potential to act 
      as biomarkers for predicting pathological features of LSCC. The high level of Fib 
      was helpful for the diagnosis of LSCC and the detection of advanced LSCC. TRIAL 
      REGISTRATION: Not applicable.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Huang, Qiongling
AU  - Huang Q
AD  - Department of Otolaryngology, the Second Affiliated Hospital, Fujian Medical 
      University, Quanzhou, 362000, Fujian Province, China.
FAU - Chen, Jing
AU  - Chen J
AD  - Quanzhou Medical College, Quanzhou, 362000, Fujian Province, China.
FAU - Huang, Yanjun
AU  - Huang Y
AD  - Department of Otolaryngology, the Second Affiliated Hospital, Fujian Medical 
      University, Quanzhou, 362000, Fujian Province, China.
FAU - Xiong, Yu
AU  - Xiong Y
AD  - Department of Neurosurgery, the Second Affiliated Hospital, Fujian Medical 
      University, Quanzhou, 362000, Fujian Province, China.
FAU - Zhou, Jiao
AU  - Zhou J
AD  - Department of Otolaryngology, the Second Affiliated Hospital, Fujian Medical 
      University, Quanzhou, 362000, Fujian Province, China.
FAU - Zhang, Yizheng
AU  - Zhang Y
AD  - Department of Otolaryngology, the Second Affiliated Hospital, Fujian Medical 
      University, Quanzhou, 362000, Fujian Province, China.
FAU - Lu, Ming
AU  - Lu M
AD  - Department of Otolaryngology, the Second Affiliated Hospital, Fujian Medical 
      University, Quanzhou, 362000, Fujian Province, China.
FAU - Hu, Weipeng
AU  - Hu W
AD  - Department of Neurosurgery, the Second Affiliated Hospital, Fujian Medical 
      University, Quanzhou, 362000, Fujian Province, China. neurosurgery_fyey@163.com.
FAU - Zheng, Feng
AU  - Zheng F
AD  - Department of Neurosurgery, the Second Affiliated Hospital, Fujian Medical 
      University, Quanzhou, 362000, Fujian Province, China. dr.feng.zheng@gmail.com.
FAU - Zheng, Chaohui
AU  - Zheng C
AD  - Department of Otolaryngology, the Second Affiliated Hospital, Fujian Medical 
      University, Quanzhou, 362000, Fujian Province, China. zchfydfsey@163.com.
LA  - eng
GR  - 2022C033R/Chaohui Zheng/
PT  - Journal Article
DEP - 20230925
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - Humans
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Retrospective Studies
MH  - *Carcinoma, Squamous Cell/pathology
MH  - *Laryngeal Neoplasms/pathology
MH  - *Head and Neck Neoplasms
PMC - PMC10519099
OTO - NOTNLM
OT  - Coagulation index
OT  - Fibrinogen
OT  - Histopathological features
OT  - Laryngeal squamous cell carcinoma
OT  - Platelet index
COIS- The authors declare no competing interests.
EDAT- 2023/09/26 00:42
MHDA- 2023/10/23 01:18
PMCR- 2023/09/25
CRDT- 2023/09/25 23:44
PHST- 2023/01/20 00:00 [received]
PHST- 2023/09/05 00:00 [accepted]
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/09/26 00:42 [pubmed]
PHST- 2023/09/25 23:44 [entrez]
PHST- 2023/09/25 00:00 [pmc-release]
AID - 10.1186/s12885-023-11381-5 [pii]
AID - 11381 [pii]
AID - 10.1186/s12885-023-11381-5 [doi]
PST - epublish
SO  - BMC Cancer. 2023 Sep 25;23(1):901. doi: 10.1186/s12885-023-11381-5.