PMID- 37753046
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230928
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 8
DP  - 2023 Aug
TI  - The Effects of Deep Brain Stimulation on Mood and Quality of Life in Parkinson's 
      Disease: A Systematic Review and Meta-Analysis.
PG  - e44177
LID - 10.7759/cureus.44177 [doi]
LID - e44177
AB  - Deep brain stimulation (DBS) is extensively used to treat motor and non-motor 
      symptoms in Parkinson's disease (PD). The aim of this study was to investigate 
      the difference between subthalamic (STN) and globus pallidus internus (GPi) DBS 
      on mood and quality of life with reference to minimal clinically important 
      differences (MCID). A systematic literature search for articles published until 
      November 2022 yielded 14 studies meeting the eligibility criteria, with a total 
      of 1,088 patients undergoing STN (n=571) or GPi (n=517) stimulation. Baseline 
      patient and clinical characteristics were comparable between the two groups. 
      Results showed that GPi stimulation demonstrated a greater reduction in the Beck 
      depression inventory (mean difference (MD)=1.68) than STN stimulation (MD=0.84). 
      Hospital anxiety and depression scale showed a 2.69- and 3.48-point decrease by 
      the GPi group in the depression and anxiety categories, respectively. The summary 
      index (SI) of the PD questionnaire depicted a greater improvement in the GPi 
      group from baseline (mean=41.01, 95% CI 34.89, 47.13) to follow-up (mean=30.85, 
      95% CI 22.08, 39.63) when compared to the STN group (baseline mean=42.43, 95% CI 
      34.50, 50.37; follow-up mean=34.21, 95% CI 25.43, 42.99). The emotions category 
      also demonstrated a similar trend. However, STN stimulation showed greater 
      reductions in motor symptoms and medication than GPi stimulation. This 
      meta-analysis demonstrated that GPi stimulation seems to offer an advantage over 
      STN stimulation in improving mood and quality of life in PD, but those effects 
      must be further validated by larger studies.
CI  - Copyright (c) 2023, El Ghazal et al.
FAU - El Ghazal, Nour
AU  - El Ghazal N
AD  - Neurosurgery, St George's University of London, London, GBR.
AD  - Neurosurgery, University of Nicosia Medical School, Nicosia, CYP.
FAU - Nakanishi, Hayato
AU  - Nakanishi H
AD  - Neurosurgery, St George's University of London, London, GBR.
AD  - Neurosurgery, University of Nicosia Medical School, Nicosia, CYP.
FAU - Martinez-Nunez, Alfonso E
AU  - Martinez-Nunez AE
AD  - Neurology, Henry Ford Health System, Detroit, USA.
FAU - Al Sabbakh, Nader K
AU  - Al Sabbakh NK
AD  - Neurosurgery, St George's University of London, London, GBR.
AD  - Neurosurgery, University of Nicosia Medical School, Nicosia, CYP.
FAU - Segun-Omosehin, Omotayo A
AU  - Segun-Omosehin OA
AD  - Neurosurgery, St George's University of London, London, GBR.
AD  - Neurosurgery, University of Nicosia Medical School, Nicosia, CYP.
FAU - Bourdakos, Natalie E
AU  - Bourdakos NE
AD  - Neurosurgery, St George's University of London, London, GBR.
AD  - Neurosurgery, University of Nicosia Medical School, Nicosia, CYP.
FAU - Nasser, Maya
AU  - Nasser M
AD  - Neurosurgery, St George's University of London, London, GBR.
AD  - Neurosurgery, University of Nicosia Medical School, Nicosia, CYP.
FAU - Matar, Reem H
AU  - Matar RH
AD  - Neurosurgery, St George's University of London, London, GBR.
AD  - Neurosurgery, University of Nicosia Medical School, Nicosia, CYP.
AD  - Gastroenterology and Hepatology, Mayo Clinic, Rochester, USA.
FAU - Than, Christian
AU  - Than C
AD  - Neurosurgery, St George's University of London, London, GBR.
AD  - Neurosurgery, University of Nicosia Medical School, Nicosia, CYP.
AD  - Biomedical Sciences, The University of Queensland, Brisbane, AUS.
FAU - Danoun, Omar A
AU  - Danoun OA
AD  - Neurology, Henry Ford Health System, Detroit, USA.
FAU - Johnson, Andrew
AU  - Johnson A
AD  - Neurological Institute, Northshore Medical Group, Chicago, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230826
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10519648
OTO - NOTNLM
OT  - deep brain stimulation
OT  - globus pallidus internus
OT  - non-motor symptoms
OT  - parkinson's disease
OT  - subthalamic nucleus
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/09/27 06:43
MHDA- 2023/09/27 06:44
PMCR- 2023/08/26
CRDT- 2023/09/27 03:42
PHST- 2023/08/26 00:00 [accepted]
PHST- 2023/09/27 06:44 [medline]
PHST- 2023/09/27 06:43 [pubmed]
PHST- 2023/09/27 03:42 [entrez]
PHST- 2023/08/26 00:00 [pmc-release]
AID - 10.7759/cureus.44177 [doi]
PST - epublish
SO  - Cureus. 2023 Aug 26;15(8):e44177. doi: 10.7759/cureus.44177. eCollection 2023 
      Aug.